Radiation-induced impairment of skeletal muscle regeneration Cover

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Radiation-induced impairment of skeletal muscle regeneration

Radiology and Oncology

Volume 59 (2025): Issue 3 (September 2025)

By: Maja Cemazar and Mihaela Jurdana

Open Access

|Sep 2025

Figures & Tables

Skeletal muscle regeneration after radiotherapy. The activation and differentiation processes of the satellite cells are controlled by growth factors (with the involvement of Pax7) and myogenic regulatory factors during the regeneration of the skeletal muscle through to the formation of new muscle fibres. Melatonin induces an increase in Pax7 expression and improves skeletal muscle differentiation, while myostatin acts as a negative regulator of muscle growth and inhibits both proliferation and differentiation of myoblasts.
IR = irradiation — Skeletal muscle regeneration after radiotherapy. The activation and differentiation processes of the satellite cells are controlled by growth factors (with the involvement of Pax7) and myogenic regulatory factors during the regeneration of the skeletal muscle through to the formation of new muscle fibres. Melatonin induces an increase in Pax7 expression and improves skeletal muscle differentiation, while myostatin acts as a negative regulator of muscle growth and inhibits both proliferation and differentiation of myoblasts. IR = irradiation

DOI: https://doi.org/10.2478/raon-2025-0048 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099

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Language: English

Page range: 293 - 300

Submitted on: Jul 9, 2025

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Accepted on: Jul 16, 2025

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Published on: Sep 5, 2025

Published by: Association of Radiology and Oncology

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

skeletal muscle,

muscle microenvironment,

muscle regeneration,

Related subjects:

Clinical medicine,

Internal medicine,

Haematology, oncology,

© 2025 Maja Cemazar, Mihaela Jurdana, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.

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