FIGURE 1.
FIGURE 2.
FIGURE 3.
Dosimetric comparison of original plan and replan for an individual patient
| Original plan | Replan | |
|---|---|---|
| Soft tissue avoid | ||
| V30Gy(%) | 10.3% | 0.3% |
| Large bowel V45Gy(%) | ||
| V45Gy(%) | 5.4% | 1.5% |
| V50Gy(%) | 1.8% | 0.4% |
| Small bowel | ||
| V30Gy(cc) | 101 cc | 82 cc |
| V45Gy(cc) | 13 cc | 6 cc |
| V50Gy(cc) | 2 cc | 1 cc |
| Rectum | ||
| Mean dose | 23 Gy | 16 Gy |
| Genitalia | ||
| Mean dose | 10 Gy | 6 Gy |
Radiographic and pathologic characteristics
| N = 20 | |
|---|---|
| Intratumoral enhancement | |
| Stable | 4 (20%) |
| Decrease | 16 (80%) |
| Peritumoral enhancement | |
| Increase | 1 (5%) |
| Not present | 15 (75%) |
| Decrease | 4 (20%) |
| Peritumoral edema | |
| Increase | 4 (20%) |
| Stable | 5 (25%) |
| Decrease | 11 (55%) |
| Fat | |
| Increase | 11 (55%) |
| Stable | 9 (45%) |
| Biopsy grade | |
| Low | 18 (90%) |
| High | 2 (10%) |
| Margin status | |
| Negative | 18 (90%) |
| Positive | 2 (10%) |
| Greatest pathologic dimension (cm) | |
| Median (IQR) | 9 (7–15) |
| Percentage viable tumor | |
| Median (IQR) | 5 (5–35) |
| Extensive pathologic response | |
| Median (IQR) | 16 (80%) |
Patient and radiotherapy characteristics
| N = 20 | |
|---|---|
| Sex | |
| Female | 8 (40%) |
| Male | 12 (60%) |
| Age (years) | |
| Median (IQR) | 51 (39–60) |
| Tumor site | |
| Lower extremity, proximal | 13 (65%) |
| Lower extremity, distal | 3 (15%) |
| Trunk | 4 (20%) |
| Recurrence | 1 (5%) |
| Chemotherapy | |
| Neoadjuvant | 1 (5%) |
| Adjuvant | 1 (5%) |
| RT modality | |
| 3D conformal | 11 (55%) |
| IMRT | 8 (40%) |
| IMPT | 1 (5%) |
| RT dose | |
| 36 Gy | 3 (15%) |
| 50 Gy | 16 (80%) |
| 56.25 Gy | 1 (5%) |
| IORT | 1 (5%) |
| Brachytherapy | 1 (5%) |