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MRI features and prognostic evaluation in patients with subventricular zone-contacting IDH-wild-type glioblastoma Cover

MRI features and prognostic evaluation in patients with subventricular zone-contacting IDH-wild-type glioblastoma

Radiology and Oncology
Volume 59 (2025): Issue 3 (September 2025)
By: Shijiao Pan,  Yang Chen,  Shan Zhao,  Jingjing Pan and  Shengsheng Xu  
Open Access
|May 2025

Figures & Tables

Figure 1.

The anatomical relationship between glioblastoma and the subventricular zone (SVZ). (A) Contrast-enhancing tumor lesions that do not contact the SVZ are classified as the SVZ non-contact group. (B) Contrastenhancing tumor lesions that contact the SVZ are classified as the SVZ contact group.
The anatomical relationship between glioblastoma and the subventricular zone (SVZ). (A) Contrast-enhancing tumor lesions that do not contact the SVZ are classified as the SVZ non-contact group. (B) Contrastenhancing tumor lesions that contact the SVZ are classified as the SVZ contact group.

FIGURE 2.

Glioblastomas with SVZ contact are further divided into four groups according to the specific regions of the lateral ventricle contacted. (A) Tumor contacting the frontal horn of the left lateral ventricle. (B) Tumor contacting the body of the left lateral ventricle. (C) Tumor contacting the temporal horn of the right lateral ventricle. (D) Tumor contacting the occipital horn of the right lateral ventricle.
Glioblastomas with SVZ contact are further divided into four groups according to the specific regions of the lateral ventricle contacted. (A) Tumor contacting the frontal horn of the left lateral ventricle. (B) Tumor contacting the body of the left lateral ventricle. (C) Tumor contacting the temporal horn of the right lateral ventricle. (D) Tumor contacting the occipital horn of the right lateral ventricle.

Figure 3.

Axial (A) and coronal (B) contrast-enhanced T1-weighted MR images of a GBM patient with multifocal manifestations. Panels (C) and (D) illustrate another GBM patient with a tumor crossing the midline, where the contrast-enhanced lesion extends from the corpus callosum to the contralateral hemisphere.
Axial (A) and coronal (B) contrast-enhanced T1-weighted MR images of a GBM patient with multifocal manifestations. Panels (C) and (D) illustrate another GBM patient with a tumor crossing the midline, where the contrast-enhanced lesion extends from the corpus callosum to the contralateral hemisphere.

FIGURE 4.

Kaplan-Meier curves for overall survival in glioblastoma: (A) Patients with and without SVZ contact; (B) Patients with tumors contacting specific SVZ regions. SVZ =subventricular zone
Kaplan-Meier curves for overall survival in glioblastoma: (A) Patients with and without SVZ contact; (B) Patients with tumors contacting specific SVZ regions. SVZ =subventricular zone

Univariate and multivariate Cox regression analyses for overall survival in glioblastoma patients

ParameterUnivariate analysisMultivariate analysis
HR95% CIP valueHR95% CIP value
Age1.0251.015–1.036< 0.001*1.0241.014–1.034< 0.001*
Gender1.0090.817–1.2470.933
Tumor size1.1121.039–1.1900.002*1.0530.966–1.1480.239
Peritumoral edema0.9500.876–1.0290.207
Tumor shape0.7830.513–1.1950.257
Enhancement type0.6870.475–0.9930.046*0.7710.532–1.1170.170
Enhancement degree1.0040.732–1.3770.980
Cystic lesion0.9040.722–1.1330.383
Necrosis1.0080.519–1.9560.982
Multifocal lesions1.6351.201–2.2250.002*1.5481.111–2.1580.010*
Crossing the midline1.7631.196–2.5990.004*1.4150.936–2.1380.099
SVZ contact1.6501.326–2.052< 0.001*1.3641.037–1.7940.027*

Comparison of clinical and MRI characteristics between the subventricular zone contact and non-contact groups

CharacteristicSVZ Contact (n = 239)SVZ Non-contact (n = 132)p value
Age (year)65 ± 1163 ± 100.085
Gender, n (%) 0.237
 Male149 (62.3)74 (56.1)
 Female90 (37.7)58 (43.9)
OS (month)11.0 (5.0–18.0)17.5 (12.0–28.5)< 0.001*
Tumor size (cm)5.07 ± 1.353.31 ± 1.12< 0.001*
Peritumoral edema (cm)1.83 (1.02–2.70)1.70 (0.55–2.62)0.192
Tumor shape/n (%) 0.016*
 Regularity10 (4.2)14 (10.6)
 Irregularity229 (95.8)118 (89.4)
Enhancement type/n (%) 0.030*
 Ring15 (6.2)17 (12.9)
 Non-ring224 (93.8)115 (87.1)
Enhancement degree/n (%) 0.386
 Significant212 (88.7)113 (85.6)
 Non-significant27 (11.3)19 (14.4)
Cystic lesion/n (%) 0.004*
 Yes83 (34.7)27 (20.5)
 No156 (65.3)105 (79.5)
Necrosis/n (%) 0.011*
 Yes237 (99.2)125 (94.7)
 No2 (0.8)7 (5.3)
Multifocal lesions (%) 0.050
 Yes37 (15.5)11 (8.3)
 No202 (84.5)121 (91.7)
Crossing the midline (%) < 0.001*
 Yes28 (11.7)0 (0.0)
 No211 (88.3)132 (100.0)
DOI: https://doi.org/10.2478/raon-2025-0029 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
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Language: English
Page range: 329 - 336
Submitted on: Jan 6, 2025
|
Accepted on: Mar 27, 2025
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Published on: May 30, 2025
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
glioblastoma,
subventricular zone,
overall survival,
MRI feature,
prognosis
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Haematology, oncology,
Radiology

© 2025 Shijiao Pan, Yang Chen, Shan Zhao, Jingjing Pan, Shengsheng Xu, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.

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