FIGURE 1.
FIGURE 2.
FIGURE 3.
FIGURE 4.
Concordance between the IHC and NGS method in determination of the COO_ The reference method was NGS_ A pairwise comparison between the results of both methods was performed for each patient_ Each patient who was subclassified into the same (ABC or GCB) subtype by both NGS and IHC was considered concordant_ Patients who were subclassified differently by IHC and NGS were considered discordant
| COO by NGS | COO by IHC | Concordance (%) | |
|---|---|---|---|
| ABC subtype | 42 | 31 | 73.8 |
| GCB subtype | 62 | 50 | 80.6 |
Patients’ characteristics
| N | % | |
|---|---|---|
| Number of patients: | 131 | |
| Gender | ||
| Male | 59 | 45.0% |
| Female | 72 | 55.0% |
| Age | ||
| Age range | 28–89 | / |
| Median age | 65 | / |
| Stages (Ann Arbor): | ||
| Stage I | 19 | 14.5% |
| Stage II | 25 | 19.0% |
| Stage III | 21 | 16.0% |
| Stage IV | 66 | 50.4% |
| Median stage: | 4 (range 1–4) | |
| Other characteristics | ||
| Bone marrow involvement | 41 | 31.3% |
| Elevated LDH level | 77 | 58.8% |
| B symptoms | 65 | 49.6% |
| IPI group: | ||
| Low risk | 32 | 24.4% |
| Low-intermediate risk | 31 | 23.7% |
| High-intermediate risk | 37 | 28.2% |
| High risk | 31 | 23.7% |
| Median IPI value: | 3 (range 0-5) | |
| Treatment | ||
| R-CHOP/R-CHOP like | 128 | 97.7% |
| R-COEP | 2 | 1.5% |
| Palliative care | 1 | 0.8% |
| Treatment response | 130 | |
| CR | 65 | 50.0% |
| PR | 48 | 36.9% |
| SD | 1 | 0.8% |
| PD | 16 | 12.3% |