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Fibulin-3 in plasma and pleural effusion as a biomarker of mesothelioma Cover

Fibulin-3 in plasma and pleural effusion as a biomarker of mesothelioma

Open Access
|Jun 2025

Figures & Tables

Figure 1.

Plasma fibulin-3 levels by group.
A = benign pleural disease related to asbestos; C = metastatic carcinomatosis; F = benign pleural effusion of other aetiologies; M = mesothelioma
Plasma fibulin-3 levels by group. A = benign pleural disease related to asbestos; C = metastatic carcinomatosis; F = benign pleural effusion of other aetiologies; M = mesothelioma

Figure 2.

Receiver-operating characteristic curve (ROC) for plasma fibulin-3 in distinguishing Group M (mesothelioma) and Group A (benign pleural disease related to asbestos).
Receiver-operating characteristic curve (ROC) for plasma fibulin-3 in distinguishing Group M (mesothelioma) and Group A (benign pleural disease related to asbestos).

Figure 3.

Fibulin-3 levels according to stage and type of malignant pleural mesothelioma (MPM).
Epit. M = epithelioid mesothelioma; G1 = Group G1, lower stage of MPM; G2 = Group G2, higher stage of MPM
Fibulin-3 levels according to stage and type of malignant pleural mesothelioma (MPM). Epit. M = epithelioid mesothelioma; G1 = Group G1, lower stage of MPM; G2 = Group G2, higher stage of MPM

Figure 4.

Correlation between fibulin-3 levels in pleural effusion and patient survival in mesothelioma patients.
Correlation between fibulin-3 levels in pleural effusion and patient survival in mesothelioma patients.

Characteristics of patients

A (n = 13)M (n = 32)C (n = 24)F (n = 21)
Age (mean, SE)68.1 (2.4)63.7 (1.9)63.1 (1.9)63.8 (3.0)
Male gender – n (%)12 (92.3)24 (75.0)14 (58.3)20 (95.2)
Smoking status – n (%)
  Active smoker1 (7.6)7 (21.9)2 (8.3)3 (14.3)
  Former smoker5 (38.5)6 (18.8)11 (45.8)11 (52.4)
  Non-smoker7 (53.8)17 (53.1)8 (33.3)4 (19.0)
Asbestos exposure – n (%)13 (100.0)19 (59.4)2 (8.3)4 (19.0)

Fibulin-3 values, presented with the median and interquartile range (IQR)

A (n = 13)M (n = 32)C (n = 24)F (n = 21)
Fibulin-3 value (ng/mL)
Plasma7.66 (4.43–8.96)9.91 (6.08–15.83)9.21 (7.97–15.93)10.15 (6.125–13.83)
Pleural effusion83.67 (15.71–87.21)78.61 (44.4–94.37)81.25 (35.86–95.45)79.64 (41.43–86.99)

Fibulin-3 levels by mesothelioma type, shown with median and interquartile range

Epitheloid typeBiphasic and sarcomatoid type
Fibulin-3 value (ng/mL)
Plasma9.96 (7.66-16.65)8.62 (5.91–13.26)
Pleural effusion66.15 (42.72-93.64)92.3 (82.6–105.2)
DOI: https://doi.org/10.2478/raon-2025-0024 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 225 - 232
Submitted on: Dec 30, 2024
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Accepted on: Jan 19, 2025
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Published on: Jun 16, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Katja Adamic, Mateja Marc Malovrh, Urska Bidovec Stojkovic, Ales Rozman, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.