FIGURE 1.
FIGURE 2.
FIGURE 3.
FIGURE 4.
FIGURE 5.
FIGURE 6.
FIGURE 7.
FIGURE 8.
Patients’ demographic parameters
| Parameter | All | Sarcoma | Breast |
|---|---|---|---|
| Number of patients (m/f) | 5/13 | 4/4 | 1/9 |
| Number of patients – visit A (baseline) | 18 | 8 | 10 |
| Number of patients – visit B (post treatment) | 14 | 6 | 8 |
| Number of patients – visit C (6 months post follow-up) | 10 | 4 | 6 |
| Age (years) | 56 ± 13 | 56 ± 15 | 55 ± 12 |
| Body mass index (BMI) (kg/m2) | 29 ± 6 | 27 ± 8 | 31 ± 4 |
| White/Black race (n) | 17/1 | 8/0 | 9/1 |
| Non-Hispanic / Hispanic (n) | 18/0 | 8/0 | 10/0 |
| Patients with cardiovascular risk factors (n) | 3 | 1 | 2 |
| Patients with comorbidities (n) | 7 | 5 | 2 |
| Patients with cardiovascular disease (n) | 1 | 1 | 0 |
| Smoker patients (n) | 7 | 3 | 4 |
| Alcohol consumer patients (n) | 8 | 3 | 5 |
| Patients receiving cardiac medications (n) | 4 | 3 | 1 |
| Accumulative Dox dose (mg) | 514 ± 190 | 564 ± 277 | 469±42 |
Cardiac MRI parameters
| Parameter | All | Sarcoma | Breast | p |
|---|---|---|---|---|
| LVEF (%) - A | 59 ± 11 | 62 ± 10 | 57 ± 12 | 0.398 |
| LVEF (%) - B | 55 ± 11 | 57 ± 8 | 53 ± 14 | 0.547 |
| LVEF (%) - C | 60 ± 5 | 58 ± 8 | 61 ± 2 | 0.489 |
| LV mass (g/m2) - A | 48 ± 10 | 48 ± 11 | 47 ± 9 | 0.849 |
| LV mass (g/m2) - B | 46 ± 8 | 51 ± 9 | 42 ± 5 | 0.049* |
| LV mass (g/m2) - C | 49 ± 8 | 53 ± 9 | 47 ± 7 | 0.300 |
| RVEF (%) - A | 50 ± 10 | 53 ± 8 | 48 ± 11 | 0.256 |
| RVEF (%) - B | 45 ± 15 | 51 ± 11 | 40 ± 17 | 0.196 |
| RVEF (%) - C | 48 ± 6 | 50 ± 5 | 47 ± 7 | 0.468 |
| GLS (%) - A | -14 ± 2 | -14 ± 2 | -14 ± 2 | 0.849 |
| GLS (%) - B | -13 ± 2 | -13 ± 2 | -14 ± 2 | 0.272 |
| GLS (%) - C | -14 ± 1 | -14 ± 1 | -13 ± 1 | 0.468 |
| GCS (%) - A | -11 ± 2 | -11 ± 3 | -11 ± 1 | 0.880 |
| GCS (%) - B | -11 ± 3 | -11 ± 3 | -11 ± 2 | 0.733 |
| GCS (%) - C | -12 ± 2 | -12 ± 2 | -11 ± 2 | 0.546 |
| GRS (%) - A | 11 ± 3 | 9 ± 3 | 12 ± 3 | 0.042* |
| GRS (%) - B | 10 ± 3 | 9 ± 3 | 10 ± 2 | 0.705 |
| GRS (%) - C | 10 ± 3 | 10 ± 3 | 11 ± 3 | 0.555 |
| T1 (ms) - A | 1264 ± 53 | 1275 ± 58 | 1255 ± 50 | 0.444 |
| T1 (ms) - B | 1309 ± 72 | 1296 ± 48 | 1319 ± 87 | 0.543 |
| T1 (ms) - C | 1289 ± 97 | 1213 ± 71 | 1339 ± 80 | 0.034* |
| T2 (ms) - A | 49 ± 5 | 48 ± 5 | 49 ± 4 | 0.529 |
| T2 (ms) - B | 49 ± 3 | 48 ± 3 | 50 ± 3 | 0.204 |
| T2 (ms) - C | 50 ± 3 | 49 ± 2 | 52 ± 4 | 0.136 |
| ECV (%) - A | 36 ± 7 | 37 ± 8 | 35 ± 6 | 0.433 |
| ECV (%) - B | 35 ± 5 | 34 ± 6 | 36 ± 4 | 0.591 |
| ECV (%) - C | 37 ± 4 | 33 ± 4 | 39 ± 3 | 0.031* |