Pulsed field ablation in medicine: irreversible electroporation and electropermeabilization theory and applications

Edward J Jacobs; Boris Rubinsky; Rafael V Davalos

doi:10.2478/raon-2025-0011

References

Gabriel B, Teissie J. Generation of reactive-oxygen species induced by electropermeabilization of Chinese hamster ovary cells and their consequence on cell viability. Eur J Biochem 1994; 223: 25-33. doi: 10.1111/j.1432-1033.1994.tb18962.x
Open DOI Search in Google Scholar Back to article
Maccarrone M, Rosato N, Agro AF. Electroporation enhances cell membrane peroxidation and luminescence. Biochem Biophys Res Commun 1995; 206: 238-45. doi: 10.1006/bbrc.1995.1033
Open DOI Search in Google Scholar Back to article
Maccarrone M, Bladergroen MR, Rosato N, Agro AF. Role of lipid peroxidation in electroporation-induced cell permeability. Biochem Biophys Res Commun 1995; 209: 417-25. doi: 10.1006/bbrc.1995.1519
Open DOI Search in Google Scholar Back to article
Bonnafous P, Vernhes MC, Teissié J, Gabriel B. The generation of reactive oxygen species associated with long-lasting pulse-induced electropermeabilisation of mammalian cells is based on a non-destructive alteration of the plasma membrane. Biochim Biophys Acta Biomembranes 1999; 1461: 123-34. doi: 10.1016/S0005-2736(99)00154-6
Open DOI Search in Google Scholar Back to article
Rems L, Viano M, Kasimova MA, Miklavčič D, Tarek M. The contribution of lipid peroxidation to membrane permeability in electropermeabilization: a molecular dynamics study. Bioelectrochemistry 2019; 125: 46-57. doi: 10.1016/j.bioelechem.2018.07.018
Open DOI Search in Google Scholar Back to article
Balantič K, Weiss VU, Pittenauer E, Miklavčič D, Kramar P. The role of lipid oxidation on electrical properties of planar lipid bilayers and its importance for understanding electroporation. Bioelectrochemistry 2023; 153: 108498. doi: 10.1016/j.bioelechem.2023.108498
Open DOI Search in Google Scholar Back to article
Rems L, Kasimova MA, Testa I, Delemotte L. Pulsed electric fields can create pores in the voltage sensors of voltage-gated ion channels. Biophys J 2020; 119: 190-205. doi: 10.1016/j.bpj.2020.05.030
Open DOI Search in Google Scholar Back to article
Geboers B, Scheffer HJ, Graybill PM, Ruarus AH, Nieuwenhuizen S, Puijk RS, et al. High-voltage electrical pulses in oncology: Irreversible electroporation, electrochemotherapy, gene electrotransfer, electrofusion, and electroimmunotherapy. Radiology 2020; 295: 254-72. doi: 10.1148/RADIOL.2020192190
Open DOI Search in Google Scholar Back to article
Neumann E, Rosenheck K. Permeability changes induced by electric impulses in vesicular membranes. J Membr Biol 1972; 10: 279-90. doi: 10.1007/BF01867861
Open DOI Search in Google Scholar Back to article
DeBruin KA, Krassowska W. Modeling electroporation in a single cell. I. Effects of field strength and rest potential. Biophys J 1999; 77: 1213-24. doi: 10.1016/S0006-3495(99)76973-0
Open DOI Search in Google Scholar Back to article
Lee RC, Gaylor DC, Bhatt D, Israel DA. Role of cell membrane rupture in the pathogenesis of electrical trauma. J Surg Res 1988; 44: 709-19. doi: 10.1016/0022-4804(88)90105-9
Open DOI Search in Google Scholar Back to article
Jacobs IV EJ, Graybill PM, Jana A, Agashe A, Nain AS, Davalos R V. Engineering high post-electroporation viabilities and transfection efficiencies for elongated cells on suspended nanofiber networks. Bioelectrochemistry 2023; 152: 108415. doi: 10.1016/j.bioelechem.2023.108415
Open DOI Search in Google Scholar Back to article
Böckmann RA, De Groot BL, Kakorin S, Neumann E, Grubmü H. Kinetics, statistics, and energetics of lipid membrane electroporation studied by molecular dynamics simulations. Biophys J 2008; 95: 1837-50. doi: 10.1529/biophysj.108.129437
Open DOI Search in Google Scholar Back to article
Neumann E, Kakorin S. Membrane electroporation: chemical thermo-dynamics and flux kinetics revisited and refined. Eur Biophys J 2018; 47: 373-87. doi: 10.1007/S00249-018-1305-3
Open DOI Search in Google Scholar Back to article
Saulis G. Pore disappearance in a cell after electroporation: theoretical simulation and comparison with experiments. Biophy J 1997; 73: 1299-309. doi: 10.1016/S0006-3495(97)78163-3
Open DOI Search in Google Scholar Back to article
Ottlakan A, Lazar G, Olah J, Nagy A, Vass G, Vaset M, et al. Current updates in bleomycin-based electrochemotherapy for deep-seated soft-tissue tumors. Electrochem 2023; 4: 282-90. doi: 10.3390/electrochem4020019
Open DOI Search in Google Scholar Back to article
Mir LM, Orlowski S, Belehradek J, Paoletti C. Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. Eur J Cancer Clin Oncol 1991; 27: 68-72. doi: 10.1016/0277-5379(91)90064-K
Open DOI Search in Google Scholar Back to article
Spiliotis AE, Holländer S, Rudzitis-Auth J, Wagenpfeil G, Eisele R, Nika S, et al. Evaluation of electrochemotherapy with bleomycin in the treatment of colorectal hepatic metastases in a rat model. Cancers 2023; 15: 1598. doi: 10.3390/cancers15051598
Open DOI Search in Google Scholar Back to article
Pakhomova ON, Gregory B, Semenov I, Pakhomov AG. Calcium-mediated pore expansion and cell death following nanoelectroporation. Biochim Biophys Acta Biomembr 2014; 1838: 2547-54. doi: 10.1016/j.bbamem.2014.06.015
Open DOI Search in Google Scholar Back to article
Szewczyk A, Gehl J, Daczewska M, Saczko J, Krog Frandsen S, Kulbacka J. Calcium electroporation for treatment of sarcoma in preclinical studies. Oncotarget 2018; 9: 11604-18. doi: 10.18632/oncotarget.24352
Open DOI Search in Google Scholar Back to article
Falk H, Matthiessen LW, Wooler G, Gehl J. Calcium electroporation for treatment of cutaneous metastases; a randomized double-blinded phase II study, comparing the effect of calcium electroporation with electrochemotherapy. Acta Oncol 2018; 57: 311-9. doi: 10.1080/0284186X.2017.1355109
Open DOI Search in Google Scholar Back to article
Frandsen SK, Gissel H, Hojman P, Tramm T, Eriksen J, Gehl J. Direct therapeutic applications of calcium electroporation to effectively induce tumor necrosis. Cancer Res 2012; 72: 1336-41. doi: 10.1158/0008-5472.CAN-11-3782
Open DOI Search in Google Scholar Back to article
Plaschke CC, Gehl J, Johannesen HH, Fisher BM, Kjaer A, Lomholt AF, et al. Calcium electroporation for recurrent head and neck cancer: a clinical phase I study. Laryngoscope Investig Otolaryngol 2019; 4: 49-56. doi:10.1002/lio2.233
Open DOI Search in Google Scholar Back to article
Kraemer MM, Tsimpaki T, Berchner-Pfannschmidt U, Bechrakis NE, Seitz B, Fiorentzis M. Calcium electroporation reduces viability and proliferation capacity of four uveal melanoma cell lines in 2D and 3D cultures. Cancers 2022; 14: 2889. doi:10.3390/cancers14122889
Open DOI Search in Google Scholar Back to article
Frandsen SK, Gibot L, Madi M, Gehl J, Rols MP. Calcium electroporation: Evidence for differential effects in normal and malignant cell lines, evaluated in a 3D spheroid model. PLoS One 2015; 10: e0144028. doi: 10.1371/journal.pone.0144028
Open DOI Search in Google Scholar Back to article
Neumann E, Schaefer-Ridder M, Wang Y, Hofschneider PH. Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J 1982; 1: 841-5. doi: 10.1002/j.1460-2075.1982.tb01257.x
Open DOI Search in Google Scholar Back to article
Rosazza C, Haberl Meglic S, Zumbusch A, Rols MP, Miklavcic D. Gene electrotransfer: a mechanistic perspective. Curr Gene Ther 2016; 16: 98-129. doi: 10.2174/1566523216666160331130040
Open DOI Search in Google Scholar Back to article
Alex A, Piano V, Polley S, Stuiver M, Voss S, Ciossani G, et al. Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology. Elife 2019; 8: e48287. doi: 10.7554/eLife.48287.001
Open DOI Search in Google Scholar Back to article
Batista Napotnik T, Polajžer T, Miklavčič D. Cell death due to electroporation – a review. Bioelectrochemistry 2021; 141: 107871. doi: 10.1016/J. BIOELECHEM.2021.107871
Open DOI Search in Google Scholar Back to article
Saulis G, Saule R. Size of the pores created by an electric pulse: microsecond vs millisecond pulses. Biochim Biophys Acta 2012; 1818: 3032-9. doi: 10.1016/j.bbamem.2012.06.018
Open DOI Search in Google Scholar Back to article
Runas KA, Malmstadt N. Low levels of lipid oxidation radically increase the passive permeability of lipid bilayers. Soft Matter 2015; 11: 499-505. doi: 10.1039/c4sm01478b
Open DOI Search in Google Scholar Back to article
Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev 2014; 2014: 360438. doi: 10.1155/2014/360438
Open DOI Search in Google Scholar Back to article
Vernier PT, Levine ZA, Wu YH, Joubert V, Ziegler MJ, Mir LM, et al. Electroporating fields target oxidatively damaged areas in the cell membrane. PLoS One 2009; 4: e7966. doi: 10.1371/journal.pone.0007966
Open DOI Search in Google Scholar Back to article
Leguèbe M, Silve A, Mir LM, Poignard C. Conducting and permeable states of cell membrane submitted to high voltage pulses: mathematical and numerical studies validated by the experiments. J Theor Biol 2014; 360: 83-94. doi: 10.1016/j.jtbi.2014.06.027
Open DOI Search in Google Scholar Back to article
Graybill PM, Davalos R V. Cytoskeletal disruption after electroporation and its significance to pulsed electric field therapies. Cancers 2020; 12: 1132. doi: 10.3390/cancers12051132
Open DOI Search in Google Scholar Back to article
Steuer A, Schmidt A, Labohá P, Babica P, Kolb JF. Transient suppression of gap junctional intercellular communication after exposure to 100-nanosecond pulsed electric fields. Bioelectrochemistry 2016; 112: 33-46. doi: 10.1016/j.bioelechem.2016.07.003
Open DOI Search in Google Scholar Back to article
Steuer A, Wende K, Babica P, Kolb JF. Elasticity and tumorigenic characteristics of cells in a monolayer after nanosecond pulsed electric field exposure. Eur Biophys J 2017; 46: 567-80. doi: 10.1007/s00249-017-1205-y
Open DOI Search in Google Scholar Back to article
Thompson GL, Roth C, Tolstykh G, Kuipers M, Ibey BL. Disruption of the actin cortex contributes to susceptibility of mammalian cells to nanosecond pulsed electric fields. Bioelectromagnetics 2014; 35: 262-72. doi: 10.1002/bem.21845
Open DOI Search in Google Scholar Back to article
Graybill PM, Jana A, Kapania RK, Nain AS, Davalos R V. Single cell forces after electroporation. ACS Nano 2021; 15: 2554-68. doi: 10.1021/acsnano.0c07020
Open DOI Search in Google Scholar Back to article
Thompson GL, Roth CC, Dalzell DR, Kuipers MA, Ibey BL. Calcium influx affects intracellular transport and membrane repair following nanosecond pulsed electric field exposure. J Biomed Opt 2014; 19: 055005. doi: 10.1117/1.jbo.19.5.055005
Open DOI Search in Google Scholar Back to article
Kanthou C, Kranjc S, Sersa G, Tozer G, Zupanic A, Cemazar M. The endothelial cytoskeleton as a target of electroporation-based therapies. Mol Cancer Ther 2006; 5: 3145-52. doi: 10.1158/1535-7163.MCT-06-0410
Open DOI Search in Google Scholar Back to article
Harkin DG, Hay ED. Effects of electroporation on the tubulin cytoskeleton and directed migration of corneal fibroblasts cultured within collagen matrices. Cell Motil Cytoskeleton 1996; 35: 345-57. doi: 10.1002/(SICI)1097-0169(1996)35:4<;345::AID-CM6>3.0.CO;2-5
Open DOI Search in Google Scholar Back to article
Thompson GL, Roth CC, Kuipers MA, Tolstykh GP, Beier HT, Ibey BL. Permeabilization of the nuclear envelope following nanosecond pulsed electric field exposure. Biochem Biophys Res Commun 2016; 470: 35-40. doi: 10.1016/j.bbrc.2015.12.092
Open DOI Search in Google Scholar Back to article
Fletcher DA, Mullins RD. Cell mechanics and the cytoskeleton. Nature 2010; 463: 485-92. doi: 10.1038/nature08908
Open DOI Search in Google Scholar Back to article
Rols MP, Teissié J. Experimental evidence for the involvement of the cytoskeleton in mammalian cell electropermeabilization. Biochim Biophys Acta 1992; 1111: 45-50. doi: 10.1016/0005-2736(92)90272-N
Open DOI Search in Google Scholar Back to article
Partridge BR, Kani Y, Lorenzo MF, Campelo SN, Allen IC, Hinckley J, et al. High-frequency irreversible electroporation (H-FIRE) induced blood–brain barrier disruption is mediated by cytoskeletal remodeling and changes in tight junction protein regulation. Biomedicines 2022; 10: 1384. doi: 10.3390/biomedicines10061384
Open DOI Search in Google Scholar Back to article
Arena CB, Garcia PA, Sano MB, et al. Focal blood-brain-barrier disruption with high-frequency pulsed electric fields. Technology 2014; 2: 206-13. doi: 10.1142/s2339547814500186
Open DOI Search in Google Scholar Back to article
Garcia PA, Rossmeisl JH, Robertson JL, Olson JD, Johnson AJ, Ellis TL, et al. 7.0-T magnetic resonance imaging characterization of acute blood-brain-barrier disruption achieved with intracranial irreversible electroporation. PLoS One 2012; 7: e50482. doi: 10.1371/journal.pone.0050482
Open DOI Search in Google Scholar Back to article
Stacey M, Fox P, Buescher S, Kolb J. Nanosecond pulsed electric field induced cytoskeleton, nuclear membrane and telomere damage adversely impact cell survival. Bioelectrochemistry 2011; 82: 131-4. doi: 10.1016/j. bioelechem.2011.06.002
Open DOI Search in Google Scholar Back to article
Xiao D, Tang L, Zeng C, Wang J, Luo X, Yao C, et al. Effect of actin cytoskeleton disruption on electric pulse-induced apoptosis and electroporation in tumour cells. Cell Biol Int 2011; 35: 99-104. doi: 10.1042/cbi20100464
Open DOI Search in Google Scholar Back to article
Davalos R V, Mir LM, Rubinsky B. Tissue ablation with irreversible electroporation. Ann Biomed Eng 2005; 33: 223-31. doi: 10.1007/s10439-005-8981-8
Open DOI Search in Google Scholar Back to article
Edd JF, Horowitz L, Davalos R V., Mir LM, Rubinsky B. In vivo results of a new focal tissue ablation technique: Irreversible electroporation. IEEE Trans Biomed Eng 2006; 53: 1409-15. doi: 10.1109/TBME.2006.873745
Open DOI Search in Google Scholar Back to article
Al-Sakere B, André F, Bernat C, Connault E, Opolon P, Davalos RV, et al. Tumor ablation with irreversible electroporation. PLoS One 2007; 2: e1135. doi: 10.1371/JOURNAL.PONE.0001135
Open DOI Search in Google Scholar Back to article
Bertacchini C, Margotti PM, Bergamini E, Lodi A, Ronchetti M, Cadossi R. Design of an irreversible electroporation system for clinical use. Technol Cancer Res Treat 2007; 6: 313-20. doi: 10.1177/15330346070060040
Open DOI Search in Google Scholar Back to article
Gielchinsky I, Lev-Cohain N. Focal irreversible electroporation for localized prostate cancer – oncological and safety outcomes using mpMRI and transperineal biopsy follow-up. Res Rep Urol 2023; 15: 27-35. doi: 10.2147/RRU. S393243
Open DOI Search in Google Scholar Back to article
Zhang K, Teoh J, Laguna P, Dominguez-Escrig J, Barret E, Ramon-Borja JC, et al. Effect of focal vs extended irreversible electroporation for the ablation of localized low-or intermediate-risk prostate cancer on early oncological control: a randomized clinical trial. JAMA Surg 2023; 158: 343-9. doi: 10.1001/jamasurg.2022.7516
Open DOI Search in Google Scholar Back to article
Prabhakar P, Avudaiappan AP, Sandman M, Eldefrawy A, Caso J, Narayanan G, et al. Irreversible electroporation as a focal therapy for localized prostate cancer: a systematic review. Indian J Urol 2024; 40: 6-16. doi: 10.4103/iju. iju_370_23
Open DOI Search in Google Scholar Back to article
van den Bos W, Jurhill RR, de Bruin DM, Savci-Heijink CD, Postema AW, Wagstaff PG, et al. Histopathological outcomes after irreversible electroporation for prostate cancer: results of an ablate and resect study. J Urol 2016; 196: 552-9. doi: 10.1016/j.juro.2016.02.2977
Open DOI Search in Google Scholar Back to article
Valerio M, Dickinson L, Ali A, Ramachadran N, Donaldson I, Mccartan N, et al. Nanoknife electroporation ablation trial: a prospective development study investigating focal irreversible electroporation for localized prostate cancer. J Urol 2017; 197: 647-54. doi: 10.1016/j.juro.2016.09.091
Open DOI Search in Google Scholar Back to article
van den Bos W, Scheltema MJ, Siriwardana AR, Kalsbeek AMF, Thompson JE, Ting F, et al. Focal irreversible electroporation as primary treatment for localized prostate cancer. BJU Int 2018; 121: 716-24. doi: 10.1111/bju.13983
Open DOI Search in Google Scholar Back to article
Onik G, Mikus P, Rubinsky B. Irreversible electroporation: Implications for prostate ablation. Technol Cancer Res Treat 2007; 6: 295-300. doi: 10.1177/153303460700600405
Open DOI Search in Google Scholar Back to article
Onik G, Rubinsky B. Irreversible electroporation: first patient experience focal therapy of prostate cancer. In: Irreversible electroporation. [internet]. 1970: 235-47. [cited 2024 Oct 15]. doi: 10.1007/978-3-642-05420-4_10. Available at: https://www.researchgate.net/publication/225882920
Open DOI Search in Google Scholar Back to article
Valerio M, Stricker PD, Ahmed HU, Dickinson L, Ponsky L, Shnier R, et al. Initial assessment of safety and clinical feasibility of irreversible electroporation in the focal treatment of prostate cancer. Prostate Cancer Prostatic Dis 2014; 17: 343-7. doi: 10.1038/pcan.2014.33
Open DOI Search in Google Scholar Back to article
Van den Bos W, De Bruin D, Veelo D, Postema AW1, Muller BG1, Varkarakis IM, et al. Quality of life and safety outcomes following irreversible electroporation treatment for prostate cancer: results from a phase I-II study. J Cancer Sci Ther 2015; 7: 312-21. doi: 10.4172/1948
Open DOI Search in Google Scholar Back to article
Tian G, Guan J, Chu Y, Zhao Q, Jiang T. Immunomodulatory effect of irreversible electroporation alone and its cooperating with immuno-therapy in pancreatic cancer. Front Oncol 2021; 11: 712042. doi: 10.3389/fonc.2021.712042
Open DOI Search in Google Scholar Back to article
Kwon D, McFarland K, Velanovich V, Martin RCG. Borderline and locally advanced pancreatic adenocarcinoma margin accentuation with intraoperative irreversible electroporation. Surgery 2014; 156: 910-20. doi: 10.1016/j. surg.2014.06.058
Open DOI Search in Google Scholar Back to article
Holland MM, Bhutiani N, Kruse EJ, Weiss MJ, Christein JD, White RR, et al. A prospective, multi-institution assessment of irreversible electroporation for treatment of locally advanced pancreatic adenocarcinoma: initial outcomes from the AHPBA pancreatic registry. HPB (Oxford) 2019; 21: 1024-31. doi: 10.1016/j.hpb.2018.12.004
Open DOI Search in Google Scholar Back to article
Belfiore MP, Ronza FM, Romano F, Ianniello GP, De Lucia G, Gallo C, et al. Percutaneous CT-guided irreversible electroporation followed by chemotherapy as a novel neoadjuvant protocol in locally advanced pancreatic cancer: our preliminary experience. Int J Surg 2015; 21(Suppl 1): S34-9. doi: 10.1016/j.ijsu.2015.06.049
Open DOI Search in Google Scholar Back to article
Spiliopoulos S, Reppas L, Filippiadis D, Delvecchio A, Conticchio M, Memeo R, et al. Irreversible electroporation for the management of pancreatic cancer: current data and future directions. World J Gastroenterol 2023; 29: 223-31. doi: 10.3748/wjg.v29.i2.223
Open DOI Search in Google Scholar Back to article
Stephens K, Philips PP, Egger ME, Scoggins CR, McMasters KM, Martin RCG. Multi-institutional review of adverse events associated with irreversible electroporation in the treatment of locally advanced pancreatic cancer. Surgery 2024; 175: 704-11. doi: 10.1016/j.surg.2023.08.042
Open DOI Search in Google Scholar Back to article
Shuiqing H, Sheng L. Is irreversible electroporation (IRE) an effective and safe ablation method for local advanced pancreatic cancer: a meta-analysis. Health Sciences Review 2022; 3: 100029. doi: 10.1016/j. hsr.2022.100029
Open DOI Search in Google Scholar Back to article
Woeste MR, Wilson KD, Kruse EJ, Weiss MJ, Christein JD, White RR, et al. Optimizing patient selection for irreversible electroporation of locally advanced pancreatic cancer: analyses of survival. Front Oncol 2022; 11: 817220. doi: 10.3389/fonc.2021.817220
Open DOI Search in Google Scholar Back to article
Pishvaian MJ, Blais EM, Brody JR, Lyons E, DeArbeloa P, Hendifar A, et al. Overall survival in patients with pancreatic cancer receiving matched therapies following molecular profiling: a retrospective analysis of the Know Your Tumor registry trial. Lancet Oncol 2020; 21: 508-18. doi: 10.1016/S1470-2045(20)30074-7
Open DOI Search in Google Scholar Back to article
He C, Wang J, Sun S, Zhang Y, Li S. Immunomodulatory effect after irreversible electroporation in patients with locally advanced pancreatic cancer. J Oncol 2019; 2019: 9346017. doi: 10.1155/2019/9346017
Open DOI Search in Google Scholar Back to article
Dai Z, Wang Z, Lei K, Liao J, Peng Z, Lin M, et al. Irreversible electroporation induces CD8+ T cell immune response against post-ablation hepatocellular carcinoma growth. Cancer Lett. 2021; 503: 1-10. doi: 10.1016/j. canlet.2021.01.001
Open DOI Search in Google Scholar Back to article
Sugimoto K, Kakimi K, Takeuchi H, Fujieda N, Saito K, Sato E, et al. Irreversible electroporation versus radiofrequency ablation: comparison of systemic immune responses in patients with hepatocellular carcinoma. J Vasc Interv Radiol 2019; 30: 845-53.e6. doi: 10.1016/j.jvir.2019.03.002
Open DOI Search in Google Scholar Back to article
Lu LC, Shao YY, Chan SY, Hsu CH, Cheng AL. Clinical characteristics of advanced hepatocellular carcinoma patients with prolonged survival in the era of anti-angiogenic targeted-therapy. Anticancer Res 2014; 34: 1047-52. doi: 10.1016/j.jvir.2019.03.002
Open DOI Search in Google Scholar Back to article
Dai Z, Wang Z, Lei K, Liao J, Peng Z, Lin M, et al. Irreversible electroporation induces CD8+ T cell immune response against post-ablation hepatocellular carcinoma growth. Cancer Lett 2021; 503: 1-10. doi: 10.1016/j. canlet.2021.01.001
Open DOI Search in Google Scholar Back to article
Narayanan G, Koethe Y, Gentile N. Irreversible electroporation of the hepatobiliary system: current utilization and future avenues. Medicina (Kaunas) 2024; 60: 251. doi: 10.3390/medicina60020251
Open DOI Search in Google Scholar Back to article
Yang Y, Qin Z, Du D, Wu Y, Qiu S, Mu F, et al. Safety and short-term efficacy of irreversible electroporation and allogenic natural killer cell immunotherapy combination in the treatment of patients with unresectable primary liver cancer. Cardiovasc Intervent Radiol 2019; 42: 48-59. doi: 10.1007/s00270-018-2069-y
Open DOI Search in Google Scholar Back to article
Guo X, Du F, Liu Q, Guo Y, Wang Q, Huang W, et al. Immunological effect of irreversible electroporation on hepatocellular carcinoma. BMC Cancer 2021; 21: 443. doi: 10.1186/s12885-021-08176-x
Open DOI Search in Google Scholar Back to article
Eller A, Schmid A, Schmidt J, May M, Brand M, Saake M, et al. Local control of perivascular malignant liver lesions using percutaneous irreversible electroporation: initial experiences. Cardiovasc Intervent Radiol 2015; 38: 152-9. doi: 10.1007/s00270-014-0898-x
Open DOI Search in Google Scholar Back to article
Beyer LP, Pregler B, Michalik K, Niessen C, Dollinger M, Müller M, et al. Evaluation of a robotic system for irreversible electroporation (IRE) of malignant liver tumors: initial results. Int J Comput Assist Radiol Surg 2017; 12: 803-9. doi: 10.1007/s11548-016-1485-1
Open DOI Search in Google Scholar Back to article
Hitpass L, Distelmaier M, Neumann UP, Schöning W, Isfort P, Keil S, Kuhl CK, et al. Recurrent colorectal liver metastases in the liver remnant after major liver surgery IRE as a salvage local treatment when resection and thermal ablation are unsuitable. Cardiovasc Intervent Radiol 2022; 45: 182-9. doi: 10.1007/s00270-021-02981-4
Open DOI Search in Google Scholar Back to article
Buijs M, Zondervan PJ, de Bruin DM, van Lienden KP, Bex A, van Delden OM. Feasibility and safety of irreversible electroporation (IRE) in patients with small renal masses: results of a prospective study. Urolo Oncol 2019; 37: 183.e1-183.e8. doi: 10.1016/j.urolonc.2018.11.008
Open DOI Search in Google Scholar Back to article
Trimmer CK, Khosla A, Morgan M, Stephenson SL, Ozayar A, Cadeddu JA. Minimally invasive percutaneous treatment of small renal tumors with irreversible electroporation: a single-center experience. J Vasc Interv Radiol 2015; 26: 1465-71. doi: 10.1016/j.jvir.2015.06.028
Open DOI Search in Google Scholar Back to article
Narayanan G, Doshi MH. Irreversible electroporation (IRE) in renal tumors. Curr Urol Rep 2016; 17: 1-7. doi: 10.1007/s11934-015-0571-1
Open DOI Search in Google Scholar Back to article
Hilton A, Kourounis G, Georgiades F. Irreversible electroporation in renal tumours: a systematic review of safety and early oncological outcomes. Urologia 2022; 89: 329-37. doi: 10.1177/03915603221077590
Open DOI Search in Google Scholar Back to article
Canvasser NE, Sorokin I, Lay AH, Morgan MSC, Ozayar A, Trimme C, et al. Irreversible electroporation of small renal masses: suboptimal oncologic efficacy in an early series. World J Urol 2017; 35: 1549-55. doi: 10.1007/s00345-017-2025-5
Open DOI Search in Google Scholar Back to article
Pech M, Janitzky A, Wendler JJ, Morgan MSC, Ozayar A, Trimmer C, et al. Irreversible electroporation of renal cell carcinoma: a first-in-man phase i clinical study. Cardiovasc Intervent Radiol 2011; 34: 132-8. doi: 10.1007/s00270-010-9964-1
Open DOI Search in Google Scholar Back to article
Deodhar A, Monette S, Single GW, Hamilton WC Jr, Thornton R, Maybody M, et al. Renal tissue ablation with irreversible electroporation: preliminary results in a porcine model. Urology 2011; 77: 754-60. doi: 10.1016/j.urology.2010.08.036
Open DOI Search in Google Scholar Back to article
Wendler JJ, Pech M, Fischbach F, Jürgens J, Friebe B, Baumunk D, et al. Initial assessment of the efficacy of irreversible electroporation in the focal treatment of localized renal cell carcinoma with delayed-interval kidney tumor resection (Irreversible Electroporation of Kidney Tumors Before Partial Nephrectomy [IRENE] trial an ablate-and-resect pilot study). Urology 2018; 114: 224-32. doi: 10.1016/j.urology.2017.12.016
Open DOI Search in Google Scholar Back to article
Neal RE, Garcia PA, Kavnoudias H, Rosenfeldt F, Mclean CA, Earl V, Bergman J, et al. In vivo irreversible electroporation kidney ablation: experimentally correlated numerical models. IEEE Trans Biomed Eng 2015; 62: 561-9. doi: 10.1109/TBME.2014.2360374
Open DOI Search in Google Scholar Back to article
Deodhar A, Monette S, Single GW, Hamilton WC Jr, Thornton R, Maybody M, et al. Renal tissue ablation with irreversible electroporation: preliminary results in a porcine model. Urology 2011; 77: 754-60. doi: 10.1016/j.urol-ogy.2010.08.036
Open DOI Search in Google Scholar Back to article
Thomson KR, Cheung W, Ellis SJ, Federman D, Kavnoudias H, Loader-Oliver D, et al. Investigation of the safety of irreversible electroporation in humans. J Vasc Interv Radiol 2011; 22: 611-21. doi: 10.1016/j.jvir.2010.12.014
Open DOI Search in Google Scholar Back to article
Min Wah T, Lenton J, Smith J, Bassett P, Jagdev S, Ralph C, et al. Irreversible electroporation (IRE) in renal cell carcinoma (RCC): a mid-term clinical experience. Eur Radiol 2021; 31: 7491-9. doi: 10.1007/s00330-021-07846-5
Open DOI Search in Google Scholar Back to article
Sorokin I, Canvasser N, Johnson B, Lucas E, Cadeddu JA. Irreversible electroporation for renal ablation does not cause significant injury to adjacent ureter or bowel in a porcine model. J Endourol 2021; 35: 873-7. doi: 10.1089/END.2020.0856
Open DOI Search in Google Scholar Back to article
Usman M, Moore W, Talati R, Watkins K, Bilfinger T V. Irreversible electroporation of lung neoplasm: a case series. Med Sci Monit 2012; 18: CS43-7. doi: 10.12659/MSM.882888
Open DOI Search in Google Scholar Back to article
Ricke J, Jürgens JHW, Deschamps F, Tselikas L, Uhde K, Kosiek O, et al. Irreversible electroporation (IRE) fails to demonstrate efficacy in a prospective multicenter phase II trial on lung malignancies: The ALICE Trial. Cardiovasc Intervent Radiol 2015; 38: 401-8. doi: 10.1007/s00270-014-1049-0
Open DOI Search in Google Scholar Back to article
Garcia PA, Kos B, Rossmeisl JH, Pavliha D, Miklavčič D, Davalos R V. Predictive therapeutic planning for irreversible electroporation treatment of spontaneous malignant glioma. Med Phys 2017; 44: 4968-80. doi: 10.1002/mp.12401
Open DOI Search in Google Scholar Back to article
Narayanan G. Irreversible electroporation. Semin Intervent Radiol 2015; 32: 349-55. doi: 10.1055/s-0035-1564706
Open DOI Search in Google Scholar Back to article
Cannon R, Ellis S, Hayes D, Narayanan G, Martin RCG. Safety and early efficacy of irreversible electroporation for hepatic tumors in proximity to vital structures. J Surg Oncol 2013; 107: 544-9. doi: 10.1002/jso.23280
Open DOI Search in Google Scholar Back to article
Aycock KN, Davalos RV. Irreversible electroporation: background, theory, and review of recent developments in clinical oncology. Bioelectricity 2019; 1: 214-34. doi: 10.1089/BIOE.2019.0029
Open DOI Search in Google Scholar Back to article
Mali B, Jarm T, Jager F, Miklavčič D. An algorithm for synchronization of in vivo electroporation with ECG. J Med Eng Technol 2005; 29: 288-96. doi: 10.1080/03091900512331332591
Open DOI Search in Google Scholar Back to article
Arena CB, Sano MB, Rossmeisl JH, Caldwell JL, Garcia PA, Rylander MN, et al. High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction. Biomed Eng Online 2011; 10: 102. doi: 10.1186/1475-925X-10-102
Open DOI Search in Google Scholar Back to article
Partridge BR, O’Brien TJ, Lorenzo MF, Coutermarsh-Ott SL, Barry SL, Stadler K, et al. High-frequency irreversible electroporation for treatment of primary liver cancer: a proof-of-principle study in canine hepatocellular carcinoma. J Vasc Interv Radiol 2020; 31: 482-91.e4. doi: 10.1016/j. jvir.2019.10.015
Open DOI Search in Google Scholar Back to article
Bhonsle S, Arena C, Sweeney D, Davalos R. Mitigation of impedance changes due to electroporation therapy using bursts of high-frequency bipolar pulses. Biomed Eng Online 2015; 14(Suppl 3): S3. doi: 10.1186/1475-925X-14-S3-S3
Open DOI Search in Google Scholar Back to article
Siddiqui IA, Latouche EL, DeWitt MR, Swet JH, Kirks RC, Baker EH, et al. Induction of rapid, reproducible hepatic ablations using next-generation, high frequency irreversible electroporation (H-FIRE) in vivo. HPB (Oxford) 2016; 18: 726-34. doi: 10.1016/j.hpb.2016.06.015
Open DOI Search in Google Scholar Back to article
Jacobs IV EJ, Campelo SN, Charlton A, Altreuter S, Davalos R V. Characterizing reversible, irreversible, and calcium electroporation to generate a burst-dependent dynamic conductivity curve. Bioelectrochemistry 2024; 155: 108580. doi: 10.1016/j.bioelechem.2023.108580
Open DOI Search in Google Scholar Back to article
Aycock KN, Vadlamani RA, Jacobs EJ, Imran KM, Verbridge SS, Allen IC, et al. Experimental and numerical investigation of parameters affecting high-frequency irreversible electroporation for prostate cancer ablation. J Biomech Eng 2022; 144: 061003. doi: 10.1115/1.4053595
Open DOI Search in Google Scholar Back to article
Ringel-Scaia VM, Beitel-White N, Lorenzo MF, Brock RM, Huie KE, Coutermarsh-Ott S, Eden K, et al. High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity. EBioMedicine 2019; 44: 112-5. doi: 10.1016/j.ebiom.2019.05.036
Open DOI Search in Google Scholar Back to article
Campelo SN, Lorenzo MF, Partridge B, Alinezhadbalalami N, Kani Y, Garcia J, et al. High-frequency irreversible electroporation improves survival and immune cell infiltration in rodents with malignant gliomas. Front Oncol 2023; 13: 1171278. doi: 10.3389/fonc.2023.1171278
Open DOI Search in Google Scholar Back to article
Hay AN, Aycock KN, Lorenzo M, David K, Coutermarsh-Ott S, Salameh Z, et al. Investigation of high frequency irreversible electroporation for canine spontaneous primary lung tumor ablation. Biomedicines 2024; 12: 2038. doi: 10.3390/biomedicines12092038
Open DOI Search in Google Scholar Back to article
Xing R, Ji S, Li X, Gong T, Jiang Q. High-frequency irreversible electroporation ablation for the prostate in Beagle dogs. Transl Androl Urol 2024; 13: 2016-26. doi: 10.21037/tau-24-108
Open DOI Search in Google Scholar Back to article
Dong S, Wang H, Zhao Y, Sun Y, Yao C. First human trial of high-frequency irreversible electroporation therapy for prostate cancer. Technol Cancer Res Treat 2018; 17: 1-9. doi: 10.1177/1533033818789692
Open DOI Search in Google Scholar Back to article
Wang H, Xue W, Yan W, Yin L, Dong B, He B, et al. Extended focal ablation of localized prostate cancer with high-frequency irreversible electroporation: a nonrandomized controlled trial. JAMA Surg 2022; 157: 693-700. doi: 10.1001/jamasurg.2022.2230
Open DOI Search in Google Scholar Back to article
Ekanem E, Reddy VY, Schmidt B, Reichlin T, Neven K, Metzner A, et al. Multi-national survey on the methods, efficacy, and safety on the postapproval clinical use of pulsed field ablation (MANIFEST-PF). Europace 2022; 24: 1256-66. doi: 10.1093/europace/euac050
Open DOI Search in Google Scholar Back to article
Reddy VY, Neuzil P, Koruth JS, Petru J, Funosako M, Cochet H, et al. Pulsed field ablation for pulmonary vein isolation in atrial fibrillation. J Am Coll Cardiol 2019; 74: 315-26. doi: 10.1016/j.jacc.2019.04.021
Open DOI Search in Google Scholar Back to article
Reddy VY, Anic A, Koruth J, Petru J, Funasako M, Minami K, et al. Pulsed field ablation in patients with persistent atrial fibrillation. J Am Coll Cardiol 2020; 76: 1068-80. doi: 10.1016/j.jacc.2020.07.007
Open DOI Search in Google Scholar Back to article
Loh P, Van Es R, Groen MHA, Neven K, Kassenberg W, Wittkampf FHM, et al. Pulmonary vein isolation with single pulse irreversible electroporation: a first in human study in 10 patients with atrial fibrillation. Circ Arrhythm Electrophysiol 2020; 13: E008192. doi: 10.1161/CIRCEP.119.008192
Open DOI Search in Google Scholar Back to article
Reddy VY, Anter E, Rackauskas G, Peichl P, Koruth JS, Petru J, et al. Latticetip focal ablation catheter that toggles between radiofrequency and pulsed field energy to treat atrial fibrillation: a first-in-human trial. Circ Arrhythm Electrophysiol 2020; 13: E008718. doi: 10.1161/CIRCEP.120.008718
Open DOI Search in Google Scholar Back to article
Reddy VY, Koruth J, Jais P, Petru J, Timko F, Skalsky I, et al. Ablation of atrial fibrillation with pulsed electric fields: an ultra-rapid, tissue-selective modality for cardiac ablation. JACC Clin Electrophysiol 2018; 4: 987-95. doi: 10.1016/j.jacep.2018.04.005
Open DOI Search in Google Scholar Back to article
Kueffer T, Madaffari A, Muehl A, Maurhofer J, Stefenova A, Seiler J, et al. Pulsed-field-vs. cryo-vs. radiofrequency ablation: one-year recurrence rates after pulmonary vein isolation in patients with paroxysmal atrial fibrillation. EP Europace 2023; 25(Suppl 1): euad122.157. doi: 10.1093/europace/euad122.157
Open DOI Search in Google Scholar Back to article
Lavee J, Onik G, Mikus P, Rubinsky B. A novel nonthermal energy source for surgical epicardial atrial ablation: Irreversible electroporation. Heart Surgery Forum 2007; 10: 96-101. doi: 10.1532/HSF98.20061202
Open DOI Search in Google Scholar Back to article
Verma A, Haines DE, Boersma LV, Sood N, Natale A, Marchlinski FE, et al. Pulsed field ablation for the treatment of atrial fibrillation: PULSED AF pivotal trial. Circulation 2023; 147: 1422-32. doi: 10.1161/CIRCULATIONAHA.123.063988
Open DOI Search in Google Scholar Back to article
Urbanek L, Bordignon S, Schaack D, Chen S, Tohoku S, Efe TH, et al. Pulsed field versus cryoballoon pulmonary vein isolation for atrial fibrillation: efficacy, safety, and long-term follow-up in a 400-patient cohort. Circ Arrhythm Electrophysiol 2023; 16: 389-98. doi: 10.1161/CIRCEP.123.011920
Open DOI Search in Google Scholar Back to article
Tabaja C, Younis A, Hussein AA, Taigen TL, Nakagawa H, Saliba WI, et al. Catheter-based electroporation: a novel technique for catheter ablation of cardiac arrhythmias. JACC Clin Electrophysiol 2023; 9: 2008-23. doi: 10.1016/j.jacep.2023.03.014
Open DOI Search in Google Scholar Back to article
Bradley CJ, Haines DE. Pulsed field ablation for pulmonary vein isolation in the treatment of atrial fibrillation. J Cardiovasc Electrophysiol 2020; 31: 2136-47. doi: 10.1111/jce.14414
Open DOI Search in Google Scholar Back to article
Sugrue A, Maor E, Ivorra A, Vaidya V, Witt C, Kapa S, et al. Irreversible electroporation for the treatment of cardiac arrhythmias. Expert Rev Cardiovasc Ther 2018; 16: 349-60. doi: 10.1080/14779072.2018.1459185
Open DOI Search in Google Scholar Back to article
Ueshima E, Schattner M, Mendelsohn R, Gerdes H, Monette S, Takaki H, et al. Transmural ablation of the normal porcine common bile duct with catheter-directed irreversible electroporation is feasible and does not impact duct patency. Gastrointest Endosc 2018; 87: 300.e1-6. doi: 10.1016/j.gie.2017.05.004
Open DOI Search in Google Scholar Back to article
Maor E, Ivorra A, Leor J, Rubinsky B. The effect of irreversible electroporation on blood vessels. Technol Cancer Res Treat 2007; 6: 307-12. doi: 10.1177/153303460700600407
Open DOI Search in Google Scholar Back to article
Narayanan G, Bhatia S, Echenique A, Suthar R, Barbery K, Yrizarry J. Vessel patency post irreversible electroporation. Cardiovasc Intervent Radiol 2014; 37: 1523-9. doi: 10.1007/s00270-014-0988-9
Open DOI Search in Google Scholar Back to article
Koruth JS, Kuroki K, Kawamura I, Brose R, Viswanathan R, Buck ED, et al. Pulsed field ablation versus radiofrequency ablation: esophageal injury in a novel porcine model. Circ Arrhythm Electrophysiol 2020; 13: E008303. doi: 10.1161/CIRCEP.119.008303
Open DOI Search in Google Scholar Back to article
Li W, Fan Q, Ji Z, Qiu X, Li Z. The effects of irreversible electroporation (IRE) on nerves. PLoS One 2011; 6: e18831. doi: 10.1371/journal.pone.0018831
Open DOI Search in Google Scholar Back to article
Moshkovits Y, Grynberg D, Heller E, Maizels L, Maor E. Differential effect of high-frequency electroporation on myocardium vs. non-myocardial tissues. Europace 2023; 25: 748-55. doi: 10.1093/europace/euac191
Open DOI Search in Google Scholar Back to article
Faroja M, Ahmed M, Appelbaum L, Ben-David E, Moussa M, Sosna J, et al. Irreversible electroporation ablation: is all the damage nonthermal? Radiology 2013; 266: 462-70. doi: 10.1148/radiol.12120609/-/DC1
Open DOI Search in Google Scholar Back to article
Appelbaum L, Ben-David E, Sosna J, Nissenbaum Y, Goldberg SN. US findings after irreversible electroporation ablation: radiologic-pathologic correlation. Radiology 2012; 262: 117-25. doi: 10.1148/radiol.11110475
Open DOI Search in Google Scholar Back to article
Kos B, Voigt P, Miklavcic D, Moche M. Careful treatment planning enables safe ablation of liver tumors adjacent to major blood vessels by percutaneous irreversible electroporation (IRE). Radiol Oncol 2015; 49: 234-41. doi: 10.1515/raon-2015-0031
Open DOI Search in Google Scholar Back to article
Kranjc M, Kranjc S, Bajd F, Serša G, Serša I, Miklavčič D. Predicting irreversible electroporation-induced tissue damage by means of magnetic resonance electrical impedance tomography. Sci Rep 2017; 7: 10323. doi: 10.1038/s41598-017-10846-5
Open DOI Search in Google Scholar Back to article
Ruarus AH, Vroomen LGPH, Geboers B, van Veldhuisen E, Puijk RS, Nieuwenhuizen S, et al. Percutaneous irreversible electroporation in locally advanced and recurrent pancreatic cancer (PANFIRE-2): a multicenter, prospective, single-arm, phase II study. Radiology 2020; 294: 212-20. doi: 10.1148/radiol.2019191109
Open DOI Search in Google Scholar Back to article
Geboers B, Timmer FEF, Ruarus AH, Pouw JEE, Schouten EAC, Bakker J, et al. Irreversible electroporation and nivolumab combined with intratumoral administration of a toll-like receptor ligand, as a means of in vivo vaccination for metastatic pancreatic ductal adenocarcinoma (Panfire-iii). A phase-I study protocol. Cancers 2021; 13: 3902. doi: 10.3390/cancers13153902
Open DOI Search in Google Scholar Back to article
Geboers B, van der Lei S, Kloppenborg LTE, Boon RM, Timmer FE, Puijk RS, et al. Transcatheter CT arteriography-guided irreversible electroporation of locally advanced pancreatic adenocarcinoma: a pictorial essay. J Med Imaging Radiat Oncol 2023; 67: 428-34. doi: 10.1111/1754-9485.13535
Open DOI Search in Google Scholar Back to article
Miklavcic D, Semrov DS, Mekid H, Mir LM. A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy. Biochim Biophys Acta 2000; 1523: 73-83. doi: 10.1016/S0304-4165(00)00101-X
Open DOI Search in Google Scholar Back to article
Ivorra A, Rubinsky B. In vivo electrical impedance measurements during and after electroporation of rat liver. Bioelectrochemistry 2007; 70: 287-95. doi: 10.1016/j.bioelechem.2006.10.005
Open DOI Search in Google Scholar Back to article
Pavšelj N, Bregar Z, Cukjati D, Batiuskaite D, Mir LM, Miklavčič D. The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumor in small animals. IEEE Trans Biomed Eng 2005; 52: 1373-81. doi: 10.1109/TBME.2005.851524
Open DOI Search in Google Scholar Back to article
Beitel-White N, Lorenzo MF, Zhao Y, Brock RM, Coutermarsh-Ott S, Allen IC, et al. Multi-tissue analysis on the impact of electroporation on electrical and thermal properties. IEEE Trans Biomed Eng 2021; 68: 771-82. doi: 10.1109/TBME.2020.3013572
Open DOI Search in Google Scholar Back to article
Jacobs EJ, Aycock KN, Santos PP, Tuohy JL, Davalos R V. Rapid estimation of electroporation-dependent tissue properties in canine lung tumors using a deep neural network. Biosens Bioelectron 2024; 244: 115777. doi: 10.1016/j.bios.2023.115777
Open DOI Search in Google Scholar Back to article
Beitel-White N, Bhonsle S, Martin RCG, Davalos RV. Electrical characterization of human biological tissue for irreversible electroporation treatments. Annu Int Conf IEEE Eng Med Biol Soc 2018; 2018: 4170-3. doi: 10.1109/EMBC.2018.8513341
Open DOI Search in Google Scholar Back to article
Brock RM, Beitel-White N, Coutermarsh-Ott S, Grider DJ, Lorenzo MF, Ringel-Scaia VM, et al. Patient derived xenografts expand human primary pancreatic tumor tissue availability for ex vivo irreversible electroporation testing. Front Oncol 2020; 10: 843. doi: 10.3389/fonc.2020.00843
Open DOI Search in Google Scholar Back to article
Kos B, Mattison L, Ramirez D, Cindrič H, Sigg DC, Iaizzo PA, et al. Determination of lethal electric field threshold for pulsed field ablation in ex vivo perfused porcine and human hearts. Front Cardiovasc Med 2023; 10: 1160231. doi:10.3389/fcvm.2023.1160231
Open DOI Search in Google Scholar Back to article
Rao X, Chen S, Alfadhl Y, Chen X, Sun L, Yu L, Zhou J, et al. Pulse width and intensity effects of pulsed electric fields on cancerous and normal skin cells. Sci Rep 2022; 12: 18039. doi: 10.1038/s41598-022-22874-x
Open DOI Search in Google Scholar Back to article
Fesmire CC, Williamson RH, Petrella RA, Kaufman JD, Topasna N, Sano MB. Integrated time nanosecond pulse irreversible electroporation (INSPIRE): assessment of dose, temperature, and voltage on experimental and clinical treatment outcomes. IEEE Trans Biomed Eng 2024; 71: 1511-20. doi:10.1109/TBME.2023.3340718
Open DOI Search in Google Scholar Back to article
Yun JH, Fang A, Khorshidi F, Habibollahi P, Kutsenko O, Etezadi V, et al. New developments in image-guided percutaneous irreversible electroporation of solid tumors. Curr Oncol Rep 2023; 25: 1213-26. doi: 10.1007/s11912-023-01452-y
Open DOI Search in Google Scholar Back to article
Martin II R, Mcfarland K, Ellis S, Velanovich V. Irreversible electroporation in locally advanced pancreatic cancer: potential improved overall survival. Ann Surg Oncol 2013; 20(Suppl 3): S443-9. doi: 10.1245/s10434-012-2736-1
Open DOI Search in Google Scholar Back to article
Cannon R, Ellis S, Hayes D, Narayanan G, Martin RCG. Safety and early efficacy of irreversible electroporation for hepatic tumors in proximity to vital structures. J Surg Oncol 2013; 107: 544-9. doi: 10.1002/jso.23280
Open DOI Search in Google Scholar Back to article
Narayanan G, Hosein PJ, Arora G, Barbery KJ, Froud T, Livingstone AS, et al. Percutaneous irreversible electroporation for downstaging and control of unresectable pancreatic adenocarcinoma. J Vasc Interv Radiol 2012; 23: 1613-21. doi: 10.1016/j.jvir.2012.09.012
Open DOI Search in Google Scholar Back to article
Akinwande O, Ahmad SS, Van Meter T, Schulz B, Martin RCG. CT Findings of patients treated with irreversible electroporation for locally advanced pancreatic cancer. J Oncol 2015; 2015: 680319. doi: 10.1155/2015/680319
Open DOI Search in Google Scholar Back to article
Lee EW, Thai S, Kee ST. Irreversible electroporation: a novel image-guided cancer therapy. Gut Liver 2010; 4(Suppl 1): S99-104. doi: 10.5009/gnl.2010.4.S1.S99
Open DOI Search in Google Scholar Back to article
Hofmann F, Ohnimus H, Scheller C, Strupp W, Zimmermann U, Jassoy C. Electric field pulses can induce apoptosis. J Membr Biol 1999; 169: 103-9. doi: 10.1007/s002329900522
Open DOI Search in Google Scholar Back to article
Piñero J, López-Baena M, Ortiz T, Cortés F. Apoptotic and necrotic cell death are both induced by electroporation in HL60 human promyeloid leukaemia cells. Apoptosis 1997; 2: 330-6. doi: 10.1023/A:1026497306006
Open DOI Search in Google Scholar Back to article
Lee EW, Chen C, Prieto VE, Dry SM, Loh CT, Kee ST. Advanced hepatic ablation technique for creating complete cell death: Irreversible electroporation. Radiology 2010; 255: 426-33. doi: 10.1148/radiol.10090337
Open DOI Search in Google Scholar Back to article
Lee EW, Loh CT, Kee ST. Imaging guided percutaneous irreversible electroporation: ultrasound and immunohistological correlation. Technol Cancer Res Treat 2007; 6: 287-93. doi: 10.1177/153303460700600404
Open DOI Search in Google Scholar Back to article
Mercadal B, Beitel-White N, Aycock KN, Castellví Q, Davalos RV, Ivorra A. Dynamics of cell death after conventional IRE and H-FIRE treatments. Ann Biomed Eng 2020; 48: 1451-62. doi: 10.1007/s10439-020-02462-8
Open DOI Search in Google Scholar Back to article
Brock RM, Beitel-White N, Davalos RV, Allen IC. Starting a fire without flame: the induction of cell death and inflammation in electroporationbased tumor ablation strategies. Front Oncol 2020; 10: 1235. doi: 10.3389/fonc.2020.01235
Open DOI Search in Google Scholar Back to article
Polajžer T, Miklavčič D. Immunogenic cell death in electroporation-based therapies depends on pulse waveform characteristics. Vaccines 2023; 11: 1036. doi: 10.3390/vaccines11061036
Open DOI Search in Google Scholar Back to article
Peng W, Polajžer T, Yao C, Miklavčič D. Dynamics of cell death due to electroporation using different pulse parameters as revealed by different viability assays. Ann Biomed Eng 2024; 52: 22-35. doi: 10.1007/s10439-023-03309-8
Open DOI Search in Google Scholar Back to article
de Visser KE, Joyce JA. The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth. Cancer Cell 2023; 41: 374-403. doi: 10.1016/j.ccell.2023.02.016
Open DOI Search in Google Scholar Back to article
Liu M, Bertolazzi G, Sridhar S, Mulder K, Syn N, Hoppe MM, et al. Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma. Nat Commun 2024; 15: 2113. doi: 10.1038/s41467-024-46220-z
Open DOI Search in Google Scholar Back to article
Ivey JW, Latouche EL, Sano MB, Rossmeisl JH, Davalos R V, Verbridge SS. Targeted cellular ablation based on the morphology of malignant cells. Sci Rep 2015; 5: 17157. doi: 10.1038/srep17157
Open DOI Search in Google Scholar Back to article
Ivey JW, Wasson EM, Alinezhadbalalami N, Kanitkar A, Debinski W, Sheng Z, et al. Characterization of ablation thresholds for 3D-cultured patient-derived glioma stem cells in response to high-frequency irreversible electroporation. Research 2019; 2019: 8081351. doi: 10.34133/2019/8081315
Open DOI Search in Google Scholar Back to article
Rolong A, Schmelz EM, Davalos RV. High-frequency irreversible electroporation targets resilient tumor-initiating cells in ovarian cancer. Integr Biol 2017; 9: 979-87. doi: 10.1039/c7ib00116a
Open DOI Search in Google Scholar Back to article
Ma Y, Xing Y, Li H, Yuan T, Liang B, Li R, et al. Irreversible electroporation combined with chemotherapy and PD-1/PD-L1 blockade enhanced antitumor immunity for locally advanced pancreatic cancer. Front Immunol 2023; 14: 1193040. doi: 10.3389/fimmu.2023.1193040
Open DOI Search in Google Scholar Back to article
Geboers B, Scheltema MJ, Jung J, Bakker J, Timmer FEF, Cerutti X, et al. Irreversible electroporation of localised prostate cancer downregulates immune suppression and induces systemic anti-tumour T-cell activation – IRE-IMMUNO study. BJU Int 2024. doi:10.1111/bju.16496
Open DOI Search in Google Scholar Back to article
He C, Huang X, Zhang Y, Lin X, Li S. T-cell activation and immune memory enhancement induced by irreversible electroporation in pancreatic cancer. Clin Transl Med 2020; 10: E39. doi: 10.1002/ctm2.39
Open DOI Search in Google Scholar Back to article
Zhao J, Wen X, Tian L, Xu C, Wen X, Melancon MP, et al. Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer. Nat Commun 2019; 10: 899. doi: 10.1038/s41467-019-08782-1
Open DOI Search in Google Scholar Back to article
Markelc B, Čemažar M, Serša G. Effects of reversible and irreversible electroporation on endothelial cells and tissue blood flow. In: Handbook of electroporation. Springer International Publishing; 2017: 607-20. doi: 10.1007/978-3-319-32886-7_70
Open DOI Search in Google Scholar Back to article
Monleón E, Lucía Ó, Güemes A, López-Alonso B, Arribas D, Sarnago H, et al. Liver tissue remodeling following ablation with irreversible electroporation in a porcine model. Front Vet Sci 2022; 9: 1014648. doi: 10.3389/fvets.2022.1014648
Open DOI Search in Google Scholar Back to article
Burbach BJ, O’Flanagan SD, Shao Q, Young KM, Slaughter JR, Rollins MR, et al. Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells. Nat Commun 2021; 12: 3862. doi: 10.1038/s41467-021-24132-6
Open DOI Search in Google Scholar Back to article
Shao Q, O’Flanagan S, Lam T, Roy P, Pelaez F, Burbach BJ, et al. Engineering T cell response to cancer antigens by choice of focal therapeutic conditions. Int J Hyperthermia 2019; 36: 130-8. doi: 10.1080/02656736.2018.1539253
Open DOI Search in Google Scholar Back to article
He C, Sun S, Zhang Y, Li S. Irreversible electroporation plus anti-pd-1 antibody versus irreversible electroporation alone for patients with locally advanced pancreatic cancer. J Inflamm Res 2021; 14: 4795-807. doi: 10.2147/JIR.S331023
Open DOI Search in Google Scholar Back to article
Jiang M, Shao Q, Slaughter J, Bischof J. Irreversible electroporation has more synergistic effect with anti-PD-1 immunotherapy than thermal ablation or cryoablation, in a colorectal cancer model. Adv Ther 2024; 7: 2400068. doi:10.1002/adtp.202400068
Open DOI Search in Google Scholar Back to article
Yang J, Eresen A, Shangguan J, Ma Q, Yaghmai V, Zhang Z. Irreversible electroporation ablation overcomes tumor-associated immunosuppression to improve the efficacy of DC vaccination in a mice model of pancreatic cancer. Oncoimmunology 2021; 10: 1875638. doi: 10.1080/2162402X.2021.1875638
Open DOI Search in Google Scholar Back to article
Dhatchinamoorthy K, Colbert JD, Rock KL. Cancer immune evasion through loss of MHC class I antigen presentation. Front Immunol 2021; 12: 636568. doi: 10.3389/fimmu.2021.636568
Open DOI Search in Google Scholar Back to article
Cornel AM, Mimpen IL, Nierkens S. MHC class I downregulation in cancer: underlying mechanisms and potential targets for cancer immunotherapy. Cancers 2020; 12: 1-33. doi: 10.3390/cancers12071760
Open DOI Search in Google Scholar Back to article
Lin M, Zhang X, Liang S, Luo H, Alnaggar M, Liu A, et al. Irreversible electroporation plus allogenic Vγ9Vδ2 T cells enhances antitumor effect for locally advanced pancreatic cancer patients. Signal Transduct Target Ther 2020; 5: 215. doi: 10.1038/s41392-020-00260-1
Open DOI Search in Google Scholar Back to article
Alnaggar M, Lin M, Mesmar A, Liang S, Qaid A, Xu K, et al. Allogenic natural killer cell immunotherapy combined with irreversible electroporation for stage IV hepatocellular carcinoma: Survival outcome. Cell Physiol Biochem 2018; 48: 1882-93. doi: 10.1159/000492509
Open DOI Search in Google Scholar Back to article
Eresen A, Yang J, Scotti A, Cai K, Yaghmai V, Zhang Z. Combination of natural killer cell-based immunotherapy and irreversible electroporation for the treatment of hepatocellular carcinoma. Ann Transl Med 2021; 9: 1089. doi: 10.21037/atm-21-539
Open DOI Search in Google Scholar Back to article
Pan Q, Hu C, Fan Y, Wang Y, Li R, Hu X. Efficacy of irreversible electroporation ablation combined with natural killer cells in treating locally advanced pancreatic cancer. J BUON. 2020; 25: 1643-49. PMID: 32862617.
Search in Google Scholar Back to article
Lin M, Liang S, Wang X, Liang Y, Zhang M, Chen J, et al. Short-term clinical efficacy of percutaneous irreversible electroporation combined with allogeneic natural killer cell for treating metastatic pancreatic cancer. Immunol Lett 2017; 186: 20-27. doi: 10.1016/j.imlet.2017.03.018
Open DOI Search in Google Scholar Back to article
Paul S, Lal G. The molecular mechanism of natural killer cells function and its importance in cancer immunotherapy. Front Immunol 2017; 8: 1124. doi: 10.3389/fimmu.2017.01124
Open DOI Search in Google Scholar Back to article
Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin 2024; 74: 203. doi: 10.3322/caac.21820
Open DOI Search in Google Scholar Back to article
Blazevski A, Scheltema MJ, Yuen B, Masand N, Nguyen TV, Delprado W, Shnier R, et al. Oncological and quality-of-life outcomes following focal irreversible electroporation as primary treatment for localised prostate cancer: a biopsy-monitored prospective cohort. Eur Urol Oncol 2020; 3: 283-90. doi: 10.1016/j.euo.2019.04.008
Open DOI Search in Google Scholar Back to article
Sivaraman A, Barret E. Focal Therapy for prostate cancer: an “à la carte” approach. Eur Urol 2016; 69: 973-5. doi: 10.1016/j.eururo.2015.12.015
Open DOI Search in Google Scholar Back to article
Ganzer R, Arthanareeswaran VKA, Ahmed HU, Cestari A, Rischmann P, Salomon G, et al. Which technology to select for primary focal treatment of prostate cancer? European Section of Urotechnology (ESUT) position statement. Prostate Cancer Prostatic Dis 2018; 21: 175-86. doi: 10.1038/s41391-018-0042-0
Open DOI Search in Google Scholar Back to article
Guenther E, Klein N, Zapf S, Weil S, Schlosser C, Rubinsky B, et al. Prostate cancer treatment with irreversible electroporation (IRE): safety, efficacy and clinical experience in 471 treatments. PLoS One 2019; 14: e0215093. doi: 10.1371/journal.pone.0215093
Open DOI Search in Google Scholar Back to article
Scheltema MJ, Geboers B, Blazevski A, Doan P, Katelaris A, Agrawal S, et al. Median 5-year outcomes of primary focal irreversible electroporation for localised prostate cancer. BJU Int 2023; 131(Suppl 4): 6-13. doi: 10.1111/bju.15946
Open DOI Search in Google Scholar Back to article
Geboers B, Scheltema MJ, Blazevski A, Katelaris A, Doan P, Ali I, et al. Median 4-year outcomes of salvage irreversible electroporation for localized radio-recurrent prostate cancer. BJU Int 2023; 131(Suppl 4): 14-22. doi: 10.1111/bju.15948
Open DOI Search in Google Scholar Back to article
Scheltema MJ, van den Bos W, Siriwardana AR, Doan P, Katelaris A, Agrawal S, et al. Feasibility and safety of focal irreversible electroporation as salvage treatment for localized radio-recurrent prostate cancer. BJU Int 2017; 120: 51-8. doi: 10.1111/bju.13991
Open DOI Search in Google Scholar Back to article
Yaxley WJ, Gianduzzo T, Kua B, Oxford R, Yaxley JW. Focal therapy for prostate cancer with irreversible electroporation: oncological and functional results of a single institution study. Investig Clin Urol 2022; 63: 285-93. doi: 10.4111/icu.20210472
Open DOI Search in Google Scholar Back to article
Park W, Chawla A, O’Reilly EM. Pancreatic cancer: a review. JAMA 2021; 326: 851-62. doi: 10.1001/jama.2021.13027
Open DOI Search in Google Scholar Back to article
Wang ZQ, Zhang F, Deng T, Zhang L, Feng F, Wang FH, et al. The efficacy and safety of modified FOLFIRINOX as first-line chemotherapy for Chinese patients with metastatic pancreatic cancer. Cancer Commun 2019; 39: 26. doi: 10.1186/s40880-019-0367-7
Open DOI Search in Google Scholar Back to article
Martin RCG, McFarland K, Ellis S, Velanovich V. Irreversible electroporation therapy in the management of locally advanced pancreatic adenocarcinoma. J Am Coll Surg 2012; 215: 361-9. doi: 10.1016/j.jamcollsurg.2012.05.021
Open DOI Search in Google Scholar Back to article
Martin RCG, Kwon D, Chalikonda S, Sellers M, Kotz E, Scoggins C, et al. Treatment of 200 locally advanced (Stage III) pancreatic adenocarcinoma patients with irreversible electroporation safety and efficacy. Anna Surg 2015; 262: 486-94. doi: 10.1097/SLA.0000000000001441
Open DOI Search in Google Scholar Back to article
Liu S, Qin Z, Xu J, Zeng J, Chen J, Niu L, et al. Irreversible electroporation combined with chemotherapy for unresectable pancreatic carcinoma: a prospective cohort study. Onco Targets Ther 2019; 12: 1341-50. doi: 10.2147/OTT.S186721
Open DOI Search in Google Scholar Back to article
Timmer FEF, Geboers B, Ruarus AH, Vroomen LGPH, Schouten EAC, van der Lei S, et al. MRI-guided stereotactic ablative body radiotherapy versus CT-guided percutaneous irreversible electroporation for locally advanced pancreatic cancer (CROSSFIRE): a single-centre, open-label, randomised phase 2 trial. Lancet Gastroenterol Hepatol 2024; 9: 448-59. doi: 10.1016/S2468-1253(24)00017-7
Open DOI Search in Google Scholar Back to article
He C, Huang X, Zhang Y, Cai Z, Lin X, Li S. Comparison of survival between irreversible electroporation followed by chemotherapy and chemotherapy alone for locally advanced pancreatic cancer. Front Oncol 2020; 10: 6. doi: 10.3389/fonc.2020.00006
Open DOI Search in Google Scholar Back to article
Oh JH, Jun DW. The latest global burden of liver cancer: a past and present threat. Clin Mol Hepatol 2023; 29: 355-7. doi: 10.3350/cmh.2023.0070
Open DOI Search in Google Scholar Back to article
Martin J, Petrillo A, Smyth EC, Shaida N, Khwaja S, Cheow HK, et al. Colorectal liver metastases: current management and future perspectives. World J Clin Oncol 2020; 11: 761-808. doi: 10.5306/wjco.v11.i10.761
Open DOI Search in Google Scholar Back to article
Niessen C, Thumann S, Beyer L, Pregler B, Kramer J, Lang S, et al. Percutaneous irreversible electroporation: long-term survival analysis of 71 patients with inoperable malignant hepatic tumors. Sci Rep 2017; 7: 43687. doi: 10.1038/srep43687
Open DOI Search in Google Scholar Back to article
Ma Y, Chen Z, Liang B, Li R, Li J, Li Z, et al. Irreversible electroporation for hepatocellular carcinoma abutting the diaphragm: a prospective single-center study. J Clin Transl Hepatol 2022; 10: 190-6. doi: 10.14218/JCTH.2021.00019
Open DOI Search in Google Scholar Back to article
Scheffer HJ, Nielsen K, van Tilborg AAJM, Vieveen JM, Bouwman RA, Kazemier G, et al. Ablation of colorectal liver metastases by irreversible electroporation: results of the COLDFIRE-I ablate-and-resect study. Eur Radiol 2014; 24: 2467-75. doi: 10.1007/s00330-014-3259-x
Open DOI Search in Google Scholar Back to article
Frühling P, Stillström D, Holmquist F, Nilsson A, Freedman J. Irreversible electroporation of hepatocellular carcinoma and colorectal cancer liver metastases: a nationwide multicenter study with short- and long-term follow-up. EJSO 2023; 49: 107046. doi: 10.1016/j.ejso.2023.107046
Open DOI Search in Google Scholar Back to article
Frühling P, Stillström D, Holmquist F, Nilsson A, Freedman J. Change in tissue resistance after irreversible electroporation in liver tumors as an indicator of treatment success - a multi-center analysis with long term follow-up. EJSO 2024; 50: 108508. doi: 10.1016/j.ejso.2024.108508
Open DOI Search in Google Scholar Back to article
Narayanan G, Gentile NT, Eyshi J, Schiro BJ, Gandhi RT, Peña CS, et al. Irreversible electroporation in treating colorectal liver metastases in proximity to critical structures. J Vasc Interv Radiol 2024; 35: 1806-13. doi: 10.1016/j.jvir.2024.08.021
Open DOI Search in Google Scholar Back to article
Zhang X, Zhang X, Ding X, Wang Z, Fan Y, Chen G, et al. Novel irreversible electroporation ablation (Nano-knife) versus radiofrequency ablation for the treatment of solid liver tumors: a comparative, randomized, multicenter clinical study. Front Oncol 2022; 12: 945123. doi: 10.3389/fonc.2022.945123
Open DOI Search in Google Scholar Back to article
Wada T, Sugimoto K, Sakamaki K, Takahashi H, Kakegawa T, Tomita Y, et al. Comparisons of radiofrequency ablation, microwave ablation, and irreversible electroporation by using propensity score analysis for early stage hepatocellular carcinoma. Cancers 2023; 15: 732. doi: 10.3390/cancers15030732
Open DOI Search in Google Scholar Back to article
Schlageter M, Terracciano LM, D’Angelo S, Sorrentino P. Histopathology of hepatocellular carcinoma. World J Gastroenterol 2014; 20: 15955-64. doi: 10.3748/wjg.v20.i43.15955
Open DOI Search in Google Scholar Back to article
Bhutiani N, Philips P, Scoggins CR, McMasters KM, Potts MH, Martin RCG. Evaluation of tolerability and efficacy of irreversible electroporation (IRE) in treatment of Child-Pugh B (7/8) hepatocellular carcinoma (HCC). HPB 2016; 18: 593-9. doi: 10.1016/j.hpb.2016.03.609
Open DOI Search in Google Scholar Back to article
Dai JC, Morgan TN, Steinberg RL, Johnson BA, Garbens A, Cadeddu JA. Irreversible lectroporation for the treatment of small renal masses: 5-year outcomes. J Endourol 2021; 35: 1586-92. doi: 10.1089/end.2021.0115
Open DOI Search in Google Scholar Back to article
Kodama H, Vroomen LG, Ueshima E, Reilly J, Brandt W, Paluch LR, et al. Catheter-based endobronchial electroporation is feasible for the focal treatment of peribronchial tumors. J Thorac Cardiovasc Surg 2018; 155: 2150-9.e3. doi: 10.1016/j.jtcvs.2017.11.097
Open DOI Search in Google Scholar Back to article
Reddy VY, Gerstenfeld EP, Natale A, Whang W, Cuoco FA, Patel C, et al. Pulsed field or conventional thermal ablation for paroxysmal atrial fibrillation. N Engl J Med 2023; 389: 1660-71. doi: 10.1056/nejmoa2307291
Open DOI Search in Google Scholar Back to article
Reddy VY, Mansour M, Calkins H, d’Avila A, Chinitz L, Woods C, et al. Pulsed field vs conventional thermal ablation for paroxysmal atrial fibrillation: recurrent atrial arrhythmia burden. J Am Coll Cardiol 2024; 84: 61-74. doi: 10.1016/j.jacc.2024.05.001
Open DOI Search in Google Scholar Back to article
Neven K, Van Es R, Van Driel V, van Wessel H, Fidder H, Vink A, et al. Acute and long-term effects of full-power electroporation ablation directly on the porcine esophagus. Circ Arrhythm Electrophysiol 2017; 10: d e004672. doi: 10.1161/CIRCEP.116.004672
Open DOI Search in Google Scholar Back to article
Reddy VY, Dukkipati SR, Neuzil P, Anic A, Petru J, Funasako M, et al. Pulsed field ablation of paroxysmal atrial fibrillation: 1-year outcomes of IMPULSE, PEFCAT, and PEFCAT II. JACC Clin Electrophysiol 2021; 7: 614-27. doi: 10.1016/j.jacep.2021.02.014
Open DOI Search in Google Scholar Back to article
Ekanem E, Neuzil P, Reichlin T, Kautzner J, van der Voort P, Jais P, et al. Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study. Nat Med 2024; 30: 2020-9. doi: 10.1038/s41591-024-03114-3
Open DOI Search in Google Scholar Back to article
Anter E, Mansour M, Nair DG, Sharma D, Taigen TL, Neuzil P, et al. Dual-energy lattice-tip ablation system for persistent atrial fibrillation: a randomized trial. Nat Med 2024; 30: 2303-10. doi: 10.1038/s41591-024-03022-6
Open DOI Search in Google Scholar Back to article
Duytschaever M, De Potter T, Grimaldi M, Anic A, Vijgen J, Neuzil P, et al. Paroxysmal atrial fibrillation ablation using a novel variable-loop biphasic pulsed field ablation catheter integrated with a 3-dimensional mapping system: 1-year outcomes of the multicenter inspIRE study. Circ Arrhythm Electrophysiol 2023; 16: E011780. doi: 10.1161/CIRCEP.122.011780
Open DOI Search in Google Scholar Back to article
Reddy VY, Calkins H, Mansour M, Wazni O, Di Biase L, Bahu M, et al. Pulsed field ablation to treat paroxysmal atrial fibrillation: safety and effectiveness in the ADMIRE pivotal trial. Circulation 2024; 150: 1174-86. doi: 10.1161/CIRCULATIONAHA.124.070333
Open DOI Search in Google Scholar Back to article
van Zyl M, Ladas TP, Tri JA, Yasin OZ, Ladejobi AO, Tan NY, et al. Bipolar electroporation across the interventricular septum: electrophysiological, imaging, and histopathological characteristics. JACC Clin Electrophysiol 2022; 8: 1106-18. doi: 10.1016/j.jacep.2022.06.002
Open DOI Search in Google Scholar Back to article
Koruth JS, Kuroki K, Iwasawa J, Viswanathan R, Brose R, Buck ED, et al. Endocardial ventricular pulsed field ablation: a proof-of-concept preclinical evaluation. Europace 2020; 22: 434-9. doi: 10.1093/europace/euz341
Open DOI Search in Google Scholar Back to article
Younis A, Buck E, Santangeli P, Tabaja C, Garrott K, Lehn L, et al. Efficacy of pulsed field vs radiofrequency for the reablation of chronic radiofrequency ablation substrate. JACC Clin Electrophysiol 2024; 10: 222-34. doi: 10.1016/j.jacep.2023.09.015
Open DOI Search in Google Scholar Back to article
Im S Il, Higuchi S, Lee A, Morrow B, Schenider K, Speltz M, et al. Pulsed field ablation of left ventricular myocardium in a swine infarct model. JACC Clin Electrophysiol 2022; 8: 722-31. doi: 10.1016/j.jacep.2022.03.007
Open DOI Search in Google Scholar Back to article
Sandhu U, Alkukhun L, Kheiri B, Hodovan J, Chiang K, Splanger T, et al. In vivo pulsed-field ablation in healthy vs. chronically infarcted ventricular myocardium: biophysical and histologic characterization. Europace 2023; 25: 1503-9. doi: 10.1093/europace/euac252
Open DOI Search in Google Scholar Back to article
Peichl P, Bulava A, Wichterle D, Schlosser F, Stojadinović P, Borišincová E, et al. Efficacy and safety of focal pulsed-field ablation for ventricular arrhythmias: two-centre experience. Europace 2024; 26: euae192. doi: 10.1093/europace/euae192
Open DOI Search in Google Scholar Back to article
Garcia PA, Pancotto T, Rossmeisl JH, Henao-Guerrero N, Gustafson NR, Daniel GB, et al. Non-thermal irreversible electroporation (N-TIRE) and adjuvant fractionated radiotherapeutic multimodal therapy for intracranial malignant glioma in a canine patient. Technol Cancer Res Treat 2011; 10: 73-83. doi: 10.7785/tcrt.2012.500181
Open DOI Search in Google Scholar Back to article
Suraju MO, Su Y, Chang J, Katwala A, Nayyar A, et al. Impact of irreversible electroporation on survival among patients with borderline resectable/locally advanced pancreatic cancer: A single center experience. Surgical Oncology Insight 2024; 1: 100075. doi: 10.1016/j.soi.2024.100075.
Open DOI Search in Google Scholar Back to article
Meijerink MR, Ruarus AH, Vroomen LG, Puijk RS, Geboers B, et al. Irreversible electroporation to treat unresectable colorectal liver metastases (COLDFIRE-2): A phase II, two-center, single-arm clinical trial. Radiology 2021; 299: 470 - 480. doi: 10.1148/RADIOL.2021203089.
Open DOI Search in Google Scholar Back to article
Esparza S, Jacobs E, Hammel J, Michelhaugh SK, Alinezhadbalamani, Nagai-Singer M, et al. Transient Lymphatic Remodeling Follows Sub-Ablative High-Frequency Irreversible Electroporation Therapy in a 4T1 Murine Model. Annals of Biomedical Engineering 2025; 3674. doi.org/10.1007/s10439-024-03674-y.
Open DOI Search in Google Scholar Back to article

Pulsed field ablation in medicine: irreversible electroporation and electropermeabilization theory and applications

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