FIGURE 1.
FIGURE 2.
FIGURE 3.
FIGURE 4.
FIGURE 5.
Univariate and multivariate Cox proportional hazards regression model of evaluation of treatment response to hepatic artery infusion chemotherapy by RECIST 1_1 and liver volumetry
| Analysis | Univariate | Multivariate | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Covariate | Category | n | Median OS (95% CI) | HR (95% CI) | p | HR (95% CI) | p | ||
| RECIST 1.1a | SD | 122 | 14.6 (11.9–17.3) | Reference | Reference | ||||
| PD | 21 | 8.5 (5.5–11.5) | 2.11 | 1.29–3.45 | 0.003 | 1.19 | 0.92–1.55 | 0.184 | |
| Liver volumetry | SD (liver volume decreases or increases up to max. 10%) | 103 | 15.9 (12.7–19.1) | Reference | Reference | ||||
| PD (liver volume increases more than 10%) | 40 | 6.6 (4.4–8.8) | 1.84 | 1.51–2.26 | <0.001 | 1.77 | 1.43–2.19 | < 0.001 | |
Comparison of median overall survival (mOS) differentiated by different changes in liver volume before and after first hepatic artery infusion chemotherapy
| Liver volume change | Log-rank (Mantel-Cox) test | |||||||
|---|---|---|---|---|---|---|---|---|
| Increase 0–10% | Increase 10–20% | Increase > 20% | ||||||
| N | mOS [months] | Chi-square | p | Chi-square | p | Chi-square | p | |
| Decrease | 53 | 15.9 | 0.1 | 0.7852 | 14.2 | 0.0002 | 32.3 | < 0.0001 |
| Increase 0–10% | 50 | 15.4 | 15.8 | < 0.0001 | 33.4 | < 0.0001 | ||
| Increase 10–20% | 25 | 7.9 | 1.9 | 0.162 | ||||
| Increase > 20% | 15 | 5.7 | ||||||
Median overall survival and accordance of treatment response evaluation by RECIST 1_1 and liver volumetry with a threshold of 10% increase in liver volume
| Liver volumetry | |||
|---|---|---|---|
| SD | PD | Total | |
| RECIST 1.1 criteria | |||
| SD | 16.6 months (n = 95) | 6.6 months (n = 27) | 14.6 months (n = 122) |
| PD | 12.8 months (n = 8) | 7.7 months (n = 13) | 8.5 months (n = 21) |
| Total | 15.9 months (n = 103) | 6.6 months (n = 40) | 12.6 months (n = 143) |
Results of evaluation of treatment response to hepatic artery infusion chemotherapy (HAIC) by RECIST 1_1 and liver volumetry
| Before first HAIC | After first HAIC | p-value | |
|---|---|---|---|
| RECIST 1.1a | |||
| (Sum of) longest diameter(s) of target lesion(s) [mm] | |||
| Total study cohort (n = 143) | 48.6 (IQR 36.3–69.2) | 50.8 (IQR 35.3–76.5) | 0.0008 |
| SD (n = 122) | 47.7 (IQR 36.2–70.5) | 48.0 (IQR 34.5–71.1) | 0.3485 |
| PD (n = 21) | 55.2 (IQR 34.3–68.9) | 73.0 (IQR 46.5–85.3) | < 0.0001 |
| Liver volumetry | |||
| Total liver volume [ml] | |||
| Total study cohort (n = 143) | 1735 (IQR 1431–2189) | 1780 (IQR 1461–2329) | < 0.0001 |
| SD (liver volume decreases or increases up to max. 10%) (n=103) | 1678 (IQR 1426–2176) | 1714 (IQR 1430–2151) | 0.6691 |
| PD (liver volume increases more than 10%) (n=40) | 1903 (IQR 1481–2529) | 2203 (IQR 1692–2946) | <0.0001 |