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Whole-body PET/MRI to detect bone metastases: comparison of the diagnostic performance of the sequences Cover

Whole-body PET/MRI to detect bone metastases: comparison of the diagnostic performance of the sequences

Open Access
|Nov 2024

Figures & Tables

FIGURE 1.

A 53-year-old woman with breast cancer. A metastasis can be observed in the L2 vertebral body (arrows) on the precontrast T1 weighted (W) image (A), contrast enhanced (CE) T1W image (B), and CE T1W VIBE-PET fused image (C). The AC PET axial image (D) does not show FDG uptake. CT yielded false-negative results (E).AC PET = attenuation-corrected raw data positron-emission tomography; FDG = fluorodeoxyglucose; VIBE = volume-interpolated breath-hold examination
A 53-year-old woman with breast cancer. A metastasis can be observed in the L2 vertebral body (arrows) on the precontrast T1 weighted (W) image (A), contrast enhanced (CE) T1W image (B), and CE T1W VIBE-PET fused image (C). The AC PET axial image (D) does not show FDG uptake. CT yielded false-negative results (E).AC PET = attenuation-corrected raw data positron-emission tomography; FDG = fluorodeoxyglucose; VIBE = volume-interpolated breath-hold examination

Diagnostic performance of sequences

SequencesSensitivity (%)Specificity (%)95%CIAUCPPPV (%)NPV (%)
Precontrast T1W785063.2–78.30.587 ± 0.0640.1917554
CE T1W VIBE825867.3–88.90.751 ± 0.0650.0247963
AC PET805467.9–79.40.667 ± 0.0650.0137858
T1W-PET8461.572.2–91.90.796 ± 0.0630.0038167
CE T1W-PET1009274.0–99.80.952 ± 0.0670.00196100

Inter-observer variability for the detection of bone metastases on all sequences

Sequenceskappa95 %CI
Precontrast T1W0.860.69–0.92
CE T1W VIBE0.870.77–0.94
AC PET0.830.76–0.90
T1W-PET0.860.78–0.91
CE T1W-PET0.880.82–0.94

Tumor histopathologic features

Primary malignant tumorsn
Hepatobiliary12
Gastrointestinal7
Genitourinary8
Breast23
Lung26
DOI: https://doi.org/10.2478/raon-2024-0062 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 494 - 500
Submitted on: Jun 2, 2024
Accepted on: Oct 24, 2024
Published on: Nov 28, 2024
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2024 Onur Levent Ulusoy, Sadık Server, Murat Yesilova, Nagihan İnan, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.