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Idarubicin-loaded drug-eluting microspheres transarterial chemoembolization for intermediate stage hepatocellular carcinoma: safety, efficacy, and pharmacokinetics Cover

Idarubicin-loaded drug-eluting microspheres transarterial chemoembolization for intermediate stage hepatocellular carcinoma: safety, efficacy, and pharmacokinetics

Open Access
|Oct 2024

Figures & Tables

FIGURE 1.

CT slices showing a mRECIST partial response to idarubicin-loaded drug-eluting microspheres (DEMIDA) - transarterial chemoembolization (TACE) in the VIII. segment of cirrhotic liver. (A) Baseline CT showing multifocal hepatocellular carcinoma (HCC). The diameter of the largest tumour was 38 mm; (B) Only minimally enhancing largest target lesion at the first treatment response evaluation, the diameter of viable lesion was 4 mm.
CT slices showing a mRECIST partial response to idarubicin-loaded drug-eluting microspheres (DEMIDA) - transarterial chemoembolization (TACE) in the VIII. segment of cirrhotic liver. (A) Baseline CT showing multifocal hepatocellular carcinoma (HCC). The diameter of the largest tumour was 38 mm; (B) Only minimally enhancing largest target lesion at the first treatment response evaluation, the diameter of viable lesion was 4 mm.

FIGURE 2.

Kaplan-Meier curve for overall survival.
Kaplan-Meier curve for overall survival.

FIGURE 3.

Geometric mean plasma concentration profiles for idarubicin (blue) and idarubicinol (purple) (n = 31). Error bars indicate first and third quartiles of plasma concentrations.
Geometric mean plasma concentration profiles for idarubicin (blue) and idarubicinol (purple) (n = 31). Error bars indicate first and third quartiles of plasma concentrations.

FIGURE 4.

Idarubicinol (A) and combined idarubicin-idarubicinol (B) plasma concentrations at 72 hours post-procedure in patients with objective response to treatment or progressive disease (n = 29).
Idarubicinol (A) and combined idarubicin-idarubicinol (B) plasma concentrations at 72 hours post-procedure in patients with objective response to treatment or progressive disease (n = 29).

Baseline patient's demographic, clinical, laboratory and imaging characteristics

Sex, number of patients (%)
  Male/female28 (90.3)/3 (9.7)
Age, years
  Mean ± SD70.6 ± 6.7
Cirrhosis, n. (%)
  Yes/No30 (96.8)/1 (3.2)
Cirrhosis aetiology, n. (%)
  Ethylic21 (67.7)
  NASH4 (12.9)
  Hemochromatosis2 (6.5)
  HBV1 (3,2)
  HCV1 (3,2)
  Cryptogenic1 (3,2)
Portal hypertension, n. (%)
  Yes/No21 (67.7)/10 (32.3)
Ascites, n. (%)
  Yes/No10 (32.3)/21(67.7)
Laboratory characteristics
  GGT, median (range) [μkat/L]1.72 (0.24–14.83)
  AST, mean ± SD [μkat/L]0.80 ± 0.26
  ALT, mean ± SD [μkat/L]0.71 ± 0.39
  Total bilirubin, mean ± SD [μmol/L]25.03 ± 15.9
  Albumin, mean ± SD [g/L]40.90 ± 5.00
  AFP, median (range) [kU/L]5.3 (1–4062.5)
Child-Pugh score (n = 30)
  Mean points ± SD5.8 ± 1.0
Child-Pugh class (n = 30)
  A/B, n (%)23 (76.7)/7 (23.3)
Imaging characteristics
  Number of lesions, mean ± SD [mm]3.1 ± 2.1
  Diameter of largest lesion, mean ± SD [mm]44.8 ± 23.0
  Cumulative diameter of lesions, mean ± SD [mm]75.7 ± 39.8
  Unilobar disease, n (%)16 (51.6)
  Bilobar disease, n (%)15 (48.4)
LVEF (%)
  Mean ± SD64.1 ± 8.7
DOI: https://doi.org/10.2478/raon-2024-0052 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 517 - 526
Submitted on: Aug 5, 2024
Accepted on: Aug 28, 2024
Published on: Oct 4, 2024
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2024 Spela Korsic, Josko Osredkar, Alojz Smid, Klemen Steblovnik, Mark Popovic, Igor Locatelli, Jurij Trontelj, Peter Popovic, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.