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Dosimetric comparison of postoperative interstitial high-dose-rate brachytherapy and modern external beam radiotherapy modalities in tongue and floor of the mouth tumours in terms of doses to critical organs Cover

Dosimetric comparison of postoperative interstitial high-dose-rate brachytherapy and modern external beam radiotherapy modalities in tongue and floor of the mouth tumours in terms of doses to critical organs

Open Access
|Nov 2023

Figures & Tables

FIGURE 1.

Representative dose distributions in a brachytherapy (BT), a volumetric modulated arc therapy (VMAT) and a Cyberknife (CK) plan.
Representative dose distributions in a brachytherapy (BT), a volumetric modulated arc therapy (VMAT) and a Cyberknife (CK) plan.

FIGURE 2.

Mean dose in % to the most exposed 2 cm3 volume of the mandible.BT = brachytherapy; CK = Cyberknife; VMAT = volumetric modulated arc therapy
Mean dose in % to the most exposed 2 cm3 volume of the mandible.BT = brachytherapy; CK = Cyberknife; VMAT = volumetric modulated arc therapy

FIGURE 3.

Mean dose to the most exposed 2 cm3 volume of the ipsilateral parotid.BT = brachytherapy; CK = Cyberknife; VMAT = volumetric modulated arc therapy
Mean dose to the most exposed 2 cm3 volume of the ipsilateral parotid.BT = brachytherapy; CK = Cyberknife; VMAT = volumetric modulated arc therapy

Mean dosimetric parameters of organs at risk (OARs) with ranges

BTVMATCKp-value*BT vs. VMAT**BT vs. CK**VMAT vs. CK**
MandibleD2 (%)47.4 (29.2–73.4)92.2 (73.1–100.4)68.4 (39.3–87.3)< 0.001< 0.001< 0.001< 0.001
D0.1 (%)73.9 (1.7–93.9)101.8 (97.1–103.9)92.3 (72.7–100.7)< 0.001< 0.001< 0.001NS
Ipsilateral parotid glandD2 (%)4.8 (2.5–11.9)7.3 (0.9–13.9)2.3 (0.3–6.7)< 0.0010.0011NS< 0.001
D0.1 (%)6.7 (3.5–19.0)13.8 (3.7–25.0)5.1 (0.3–12.3)< 0.001< 0.001NS< 0.001
Contralateral parotid glandD2 (%)3. (0.0–7.6)6.8 (0.6–15.8)1.5 (0.0–4.7)< 0.0010.0018NS< 0.001
D0.1 (%)4.9 (0.0–11.9)10.9 (0.9–20.2)3.3 (0.3–14.0)< 0.0010.0105NS0.0020
Contralateral submandibular glandD2 (%)7.3 (3.9–16.3)9.0 (0.8–17.7)3.6 (2.0–6.0)0.0098NS0.01980.0016
D0.1 (%)9.4 (6.2–21.4)14.3 (2.1–23.1)5.6 (3.0–11.3)0.0098NS0.0146< 0.001

Mean dosimetric parameters of planning target volume (PTV) with ranges

BTVMATCKp-value*BT vs. VMAT**BT vs. CK**VMAT vs. CK**
VPTV (cm3)12.5 (2.6–21.5)26.5 (7.7–42.6)17.5 (5.6–33.6)< 0.001< 0.0010.55530.0043
Conformal index0.62 (0.48–0.80)0.84 (0.78–0.87)0.86 (0.79–0.93)< 0.001< 0.001< 0.0010.5480
Homogenity indexDNR = 0.38 (0.30–0.50)0.09 (0.05 – 0.10)0.20 (0.17–0.20)NANANA< 0.001
DOI: https://doi.org/10.2478/raon-2023-0050 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 516 - 523
Submitted on: May 19, 2023
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Accepted on: Aug 23, 2023
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Published on: Nov 30, 2023
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2023 Örs Ferenczi, Tibor Major, Georgina Fröhlich, Dalma Béla, Szabolcs Tódor, Csaba Polgár, Hironori Akiyama, Botond Bukovszky, Zoltán Takácsi-Nagy, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.