Apparent diffusion coefficient measurements of bone marrow infiltration patterns in multiple myeloma for the assessment of tumor burden – a feasibility study Cover

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Apparent diffusion coefficient measurements of bone marrow infiltration patterns in multiple myeloma for the assessment of tumor burden – a feasibility study

Radiology and Oncology

Volume 57 (2023): Issue 4 (December 2023)

By: Xing Xiong, Yuzhu Ma, Yao Dai, Chunhong Hu and Yu Zhang

Open Access

|Nov 2023

Figures & Tables

Five bone marrow infiltration patterns of multiple myeloma patients and healthy controls: pure diffuse pattern (A, B), combined diffuse/focal pattern (C, D), focal pattern (E, F), salt and pepper pattern (G, H), normal pattern (I, J), healthy control (K, L). T1 weighted(WI) image (A, C, E, G, I, K), T2WI FS image (B, D, F, H, J, L).

ROC curve analysis of discriminating multiple myeloma (MM) infiltration patterns of D from N by quantitative parameters of apparent diffusion coefficient (ADC).D = pure diffuse pattern; N = normal pattern

ROC curve analysis of discriminating multiple myeloma (MM) infiltration patterns of N from healthy controls by quantitative parameters of apparent diffusion coefficient (ADC).N = normal

ROC curve analysis of discriminating healthy controls from multiple myeloma (MM) infiltration bone marrow by quantitative parameters of apparent diffusion coefficient (ADC).

Correlation analysis of bone marrow plasma cell ratio and mean apparent diffusion coefficient (ADCmean) values of diffuse infiltration patterns (N and D) in multiple myeloma (MM) patients.D = pure diffuse pattern; N = normal pattern

Beta-2 microglobulin (β2-MG) characteristics of multiple myeloma (MM) patients with different magnetic resonance imaging (MRI) infiltration patterns

MRI pattern	β2-MG^a (mg/L)	P

		D	M	F	SP	N
D	9.3 ± 8.8		> 0.05	< 0.05	< 0.05	< 0.05
M	10.7 ± 13.9			< 0.05	< 0.05	< 0.05
F	4.4 ± 5.2				> 0.05	> 0.05
SP	2.9 ± 1.5					> 0.05
N	3.6 ± 2.4

The laboratory data of patients

Characteristics	Number / mean ± standard deviation
MM subtype^a
lgG-K	28
lgG-λ	21
IgA-K	8
lgA-λ	11
IgM-K	1
K	5
λ	19
ISS stage^a
I/ II/ III	18/ 48/ 27
R-ISS stage^a
I/ II/ III	14/ 63/ 16
FISH^a
HRC/SRC	20 / 73
Plasma cells in BM (%)^b	34.4 ± 22.3
Serum M protein^b	36.6 ± 23.7
Hemoglobin^b	93.3 ± 23.1
Serum β2-MG^b	6.6 ± 8.5
Serum creatinine^b	127.3 ± 143.3
LDH^b	197.9 ± 115.1

Hemoglobin characteristics of multiple myeloma (MM) patients with different magnetic resonance imaging (MRI) infiltration patterns

MRI pattern	Haemoglobin^a (g/L)	P

		D	M	F	SP	N
D	77.0 ± 19.5		> 0.05	0.001	0.014	< 0.001
M	88.9 ± 21.1			> 0.05	> 0.05	0.009
F	100.8 ± 17.8				> 0.05	> 0.05
SP	97.6 ± 20.0					> 0.05
N	106.7 ± 23.8

Serum M protein characteristics of multiple myeloma (MM) patients with different magnetic resonance imaging (MRI) infiltration patterns

MRI pattern	M protein^a (g/L)	P

		D	M	F	SP	N
D	46.9 ± 27.6		> 0.05	> 0.05	> 0.05	< 0.05
M	49.8 ± 18.9			> 0.05	> 0.05	> 0.05
F	33.4 ± 20.8				> 0.05	> 0.05
SP	40.3 ± 18.8					< 0.05
N	19.9 ± 16.9

Plasma cells characteristics of multiple myeloma (MM) patients with different magnetic resonance imaging (MRI) infiltration patterns

MRI pattern	plasma cells^a (%)	P

		D	M	F	SP	N
D	46.9 ± 20.1		> 0.05	> 0.05	< 0.05	< 0.001
M	50.3 ± 23.1			< 0.05	< 0.05	< 0.001
F	34.9 ± 17.8				> 0.05	< 0.05
SP	18.8 ± 8.3					< 0.05
N	15.7 ± 11.2

DOI: https://doi.org/10.2478/raon-2023-0048 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099

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Language: English

Page range: 455 - 464

Submitted on: Jun 1, 2023

Accepted on: Jul 22, 2023

Published on: Nov 30, 2023

Published by: Association of Radiology and Oncology

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

multiple myeloma,

infiltration pattern,

apparent diffusion coefficient

Related subjects:

Clinical medicine,

Internal medicine,

Haematology, oncology,

© 2023 Xing Xiong, Yuzhu Ma, Yao Dai, Chunhong Hu, Yu Zhang, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.

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