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Does tumor rupture during robot-assisted partial nephrectomy have an impact on mid-term tumor recurrences? Cover

Does tumor rupture during robot-assisted partial nephrectomy have an impact on mid-term tumor recurrences?

Open Access
|Jul 2023

Figures & Tables

FIGURE 1.

(A) Example of tumor rupture during enucleation of a renal tumor. (B) Tumor bed after the tumor was completely removed from healthy kidney parenchyma (intraoperative snapshots).
(A) Example of tumor rupture during enucleation of a renal tumor. (B) Tumor bed after the tumor was completely removed from healthy kidney parenchyma (intraoperative snapshots).

Patient and tumor characteristics in the no tumor rupture group and the tumor rupture group

No tumor rupture (N = 86)Tumor rupture (N = 14)P value
Patients, n (%)
  Male59 (69)9 (64)0.8
  Female27 (31)5 (36)
Age (years), median (IQR)60 (52–67)60 (49–68)0.9
Tumor size (mm), median (IQR)30 (23–40)37 (30–48)0.2
RENAL nephrometry score, median (IQR)*7 (5–8)8 (6.25–9.75)0.028
Laterality, n (%)
  Right kidney40 (47)6 (43)0.8
  Left kidney46 (53)8 (57)
Tumor localization, n (%)
  Upper third24 (28)5(36)0.8
  Middle third34 (39)5 (36)
  Lower third28 (33)4 (28)
Preoperative CT/MRI, n (%)
  Tumor72 (84)13 (93)0.4
  Cystic14 (16)1 (7)

Pathologic characteristics and oncologic outcome in the no tumor rupture group and the tumor rupture group

No tumor rupture (N = 86), n (%)Tumor rupture (N = 14), n (%)P value
Histology 0.043
  Benign8 (9)1 (7)
  Oncocytoma7 (8)1 (7)
  Clear cell RCC44 (51)2 (14)
  Papillary RCC15 (17)8 (57)
  Chromophobe RCC5 (6)1 (7)
  Clear cell papillary RCC4 (5)0 (0)
  Other types of RCC3 (3)1 (7)
WHO/ISUP grade (RCC) 0.6
  121 (35)2 (25)
  235 (58)6 (75)
  34 (7)0 (0)
Pathologic stage 0.4
  1a58 (82)9 (75)
  1b9 (13)2 (17)
  2a1 (1)1 (8)
  33 (4)0 (0)
Positive surgical margins1 (1)0 (0)0.7
Local or distant recurrence0 (0)0 (0)

Perioperative and postoperative outcomes in the no tumor rupture group and the tumor rupture group

No tumor rupture (N = 86)Tumor rupture (N = 14)P value
Operative time (min), median (IQR)140 (115–171)147 (135–168)0.4
WIT (min), median (IQR)15 (12–19)22 (15–25)0.026
No clamping, n (%)8 (9)0 (0)
Length of stay after surgery (days), median (IQR)3 (2–3)3 (2–3)0.8
Creatinine (μmol/L), median (IQR)
  Preoperative80 (73–94)80 (77–87)0.9
  2 days after RAPN80 (70–98)80 (75–89)0.6
  Variation1 (−7 to 7)1 (−7 to 8)0.7
Intraoperative EBL (mL), median (IQR)20 (0–50)50 (20–100)0.13
Hemoglobin (g/L), median (IQR)
  Preoperative148 (140–155)148 (144–152)0.7
  2 days after RAPN125 (119–133)125 (122–129)0.8
  Variation22 (14–27)25 (20–27)0.6
Transfusions, n (%)3 (3)0
Major complications (Clavien-Dindo ≥ 3), n (%)2 (2)0
Conversions to radical nephrectomy, n (%)2 (2)0 (0)
DOI: https://doi.org/10.2478/raon-2023-0031 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 348 - 355
Submitted on: Apr 19, 2023
Accepted on: May 23, 2023
Published on: Jul 20, 2023
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2023 Simon Hawlina, Kosta Cerovic, Andraz Kondza, Peter Popovic, Jure Bizjak, Tomaz Smrkolj, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.