Figure
Flow chart to illustrate the process by which articles were selected or rejected for inclusion in the study.
Table
Characteristics of 12 selected studies
| Author | Year | Study design | Thymoma | Gene (SNV) | Number of cases | number Total of cases | NGS genomics |
|---|---|---|---|---|---|---|---|
| APC | 23 | ||||||
| TP53 | 12 | ||||||
| ATM | 22 | ||||||
| Chen K, China | 2020 | Cross-sectional | Type A, AB, B1, B2, B3 | AKT1 | 5 | 50 | TS |
| SMAD4 | 12 | ||||||
| ALK | 19 | ||||||
| KRAS | 2 | ||||||
| NRAS | 2 | ||||||
| HRAS | 3 | ||||||
| Enkner F, Austria | 2017 | Cross-sectional | Type A, B | SMARCB1 | 1 | 19 | TS |
| STK11 | 1 | ||||||
| Higuchi R, Japan | 2020 | Cross-sectional | Type A, AB, B | GTF2I | 14 | 22 | TS |
| Petrini I, Italia | 2014 | Cross-sectional | Type A, AB | GTF2I | 119 | 270 | ES |
| GTF2I | 44 | ||||||
| Radovich M, USA | 2017 | Case-control | Type A, AB | HRAS | 10 | 105 | MOPA |
| TP53 | 2 | ||||||
| HRAS | 1 | ||||||
| PIK3CA | 2 | SNaPshot | |||||
| Sakane T, Japan | 2020 | Cross-sectional | Type A, B2, B3, B4, B5 | AKT1 | 1 | 33 | |
| RAS pathway | 1 | Multiplex | |||||
| EGFR pathway | 3 | ||||||
| Song ZB, China | 2016 | Type B2, B3 | PIK3CA | 1 | 37 | TS | |
| EGFR | 1 | IonAmpliSeq | |||||
| SMAD4 | 27 | ||||||
| APC | 27 | ||||||
| Peric J, Serbia | 2020 | Case-control | Type A, B1, B2, B3 | ATM | 26 | 35 | TSACP |
| ERBB4 | 24 | ||||||
| TP53 | 26 | ||||||
| Xu S, China | 2021 | Cross-sectional | Type A, AB B1, B2, B3 | TP53 | 9 | 17 | ES |
| HRAS | 2 | ||||||
| Liang N, China | 2021 | Cross-sectional | Type A, AB, B1, B2, B3 | GTF2I | 15 | 24 | SureSelectXT TS |
| Szpechcinski A, Poland | 2022 | Cross-sectional | Type B2B3 | ERBBKIT 2 | 11 | 19 | TS |
| KIT | 1 | ||||||
| Girard N, France | 2022 | Cross-sectional | Type A, B1, B2, B3 | TPHRAS 53 | 81 | 90 | WES |
| Other genes | 80 |
Figure
Forest plot of GTH2I gene in thymoma.
Figure
Forest plot of TP53 gene in thymoma.
Figure
Forest plot of HRAS gene in thymoma.
Figure
Funnel plot of GTF2I gene in thymoma.
Figure
Funnel plot of TP53 gene in thymoma.
Figure
Funnel plot of HRAS gene in thymoma.