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Characteristics of 12 selected studies
| Author | Year | Study design | Thymoma | Gene (SNV) | Number of cases | number Total of cases | NGS genomics |
|---|---|---|---|---|---|---|---|
| APC | 23 | ||||||
| TP53 | 12 | ||||||
| ATM | 22 | ||||||
| Chen K, China | 2020 | Cross-sectional | Type A, AB, B1, B2, B3 | AKT1 | 5 | 50 | TS |
| SMAD4 | 12 | ||||||
| ALK | 19 | ||||||
| KRAS | 2 | ||||||
| NRAS | 2 | ||||||
| HRAS | 3 | ||||||
| Enkner F, Austria | 2017 | Cross-sectional | Type A, B | SMARCB1 | 1 | 19 | TS |
| STK11 | 1 | ||||||
| Higuchi R, Japan | 2020 | Cross-sectional | Type A, AB, B | GTF2I | 14 | 22 | TS |
| Petrini I, Italia | 2014 | Cross-sectional | Type A, AB | GTF2I | 119 | 270 | ES |
| GTF2I | 44 | ||||||
| Radovich M, USA | 2017 | Case-control | Type A, AB | HRAS | 10 | 105 | MOPA |
| TP53 | 2 | ||||||
| HRAS | 1 | ||||||
| PIK3CA | 2 | SNaPshot | |||||
| Sakane T, Japan | 2020 | Cross-sectional | Type A, B2, B3, B4, B5 | AKT1 | 1 | 33 | |
| RAS pathway | 1 | Multiplex | |||||
| EGFR pathway | 3 | ||||||
| Song ZB, China | 2016 | Type B2, B3 | PIK3CA | 1 | 37 | TS | |
| EGFR | 1 | IonAmpliSeq | |||||
| SMAD4 | 27 | ||||||
| APC | 27 | ||||||
| Peric J, Serbia | 2020 | Case-control | Type A, B1, B2, B3 | ATM | 26 | 35 | TSACP |
| ERBB4 | 24 | ||||||
| TP53 | 26 | ||||||
| Xu S, China | 2021 | Cross-sectional | Type A, AB B1, B2, B3 | TP53 | 9 | 17 | ES |
| HRAS | 2 | ||||||
| Liang N, China | 2021 | Cross-sectional | Type A, AB, B1, B2, B3 | GTF2I | 15 | 24 | SureSelectXT TS |
| Szpechcinski A, Poland | 2022 | Cross-sectional | Type B2B3 | ERBBKIT 2 | 11 | 19 | TS |
| KIT | 1 | ||||||
| Girard N, France | 2022 | Cross-sectional | Type A, B1, B2, B3 | TPHRAS 53 | 81 | 90 | WES |
| Other genes | 80 |