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Treatment of vulvar cancer recurrences with electrochemotherapy – a detailed analysis of possible causes for unsuccessful treatment Cover

Treatment of vulvar cancer recurrences with electrochemotherapy – a detailed analysis of possible causes for unsuccessful treatment

Radiology and Oncology
Volume 57 (2023): Issue 1 (March 2023)
By: Gregor Vivod,  Tanja Jesenko,  Gorana Gasljevic,  Nina Kovacevic,  Masa Bosnjak,  Gregor Sersa,  Sebastjan Merlo and  Maja Cemazar  
Open Access
|Feb 2023

Figures & Tables

Figure 1

(A) Local recurrence of vulvar cancer. (B) No response to treatment two months after electrochemotherapy.

Figure 2

Hematoxylin and eosin stained sections of primary (A) and post-electrochemotherapy (B) biopsy. Scale bar represents 50 μm.

Figure 3

Immunohistologically stained sections for lymphocytes CD3 (A), macrophages CD68 PMG1 (B) and CD163 (C), and blood vessels ERG (D), from primary biopsy (Primary Bx) and post-electrochemotherapy biopsy (post-ECT Bx) samples. Scale bar represents 50 μm. The number of positively stained regions ± standard error of the mean (SEM) is presented.

Review of studies evaluating electrochemotherapy in vulvar cancer

First author, year publishedIncluded no. of patientsAverage ageHistologyResponse of vulvar cancer
ORNR
Perrone, 201320884y8 SCC6/8 (75%)2/8 (25%)
Perrone, 2015212585y25 SCC20/25 (80%)5/20 (20%)
Pellegrino, 2016181068y1 9 Paget’s SCC6/10 (60%)4/10 (40%)
Perrone, 2019135579y57 SCC 3 Paget’s 1 melanoma46/55 (84%)9/55 (16%)
Corrado, 2020161583y14 1 SCC CS12/15 (80%)3/15 (20%)
DOI: https://doi.org/10.2478/raon-2023-0010 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
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Language: English
Page range: 121 - 126
Submitted on: Dec 21, 2022
|
Accepted on: Jan 11, 2023
|
Published on: Feb 17, 2023
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
electrochemotherapy,
bleomycin,
vulvar cancer,
recurrence
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Haematology, oncology,
Radiology

© 2023 Gregor Vivod, Tanja Jesenko, Gorana Gasljevic, Nina Kovacevic, Masa Bosnjak, Gregor Sersa, Sebastjan Merlo, Maja Cemazar, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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