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Evaluation of toxic effects of chemotherapy in lung malignancies on cerebral white matter using diffusion tensor imaging Cover

Evaluation of toxic effects of chemotherapy in lung malignancies on cerebral white matter using diffusion tensor imaging

Radiology and Oncology
Volume 56 (2022): Issue 2 (June 2022)
By: ,  ,  ,  ,  ,  ,   and    
Open Access
|May 2022
Figures & tables

Figures & Tables

Figure 1

Fractional anisotropy value measurement at the genu and splenium of corpus callosum (circles).

Table 1

Fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity (MD) and radial diffusivity (RD) values of the defined regions of interest in the patients with non-small cell lung cancer (NSCLC) and the control group

Regions of interestNSCLC patients (n = 25)Control (n = 27)
FAADMDRDFAADMDRD
R ILF591.86±74.621500.75±122.17863.76±65.15545.27±96.29575.66±79.551458.45±131.20843.76±76.46536.41±93.74
L ILF600.06±59.941529.15±173.76868.6±97.02538.32±103.53613.26±80.831543.02±136.96856.6±105.47513.38±125.10
R SLF558.53±114.371299.28±201.73754.18±67.60481.63±88.42595.02±87.691411.18±141.51792.77±46.74483.57±74.45
L SLF532.01±118.551299.01±173.29778.50±71.55518.24±110.51591.15±96.811416±149.16795.97±59.44485.95±82.96
R FM554.53±100.651338.19±156.48769.57±105.53512.13±99.98629.28±151.291508.51±288.33813.40±80.35465.84±139.28
L FM507.28±109.361307.52±188.16807.18±63.09557.02±109.36653.10±173.431605.51±322.02836.1±86.54451.52±168.22
R ATR340.74±88.421103.33±81.11808.82±52.68661.56±75.32356.29±93.061079.83±101.61785.80±60.54638.79±74.98
L ATR346.5±80.361106.73±129.93787.19±107.16654.76±99.75370.34±99.101106.84±127.16795.80±78.49640.28±91.63
R ACR462.64±165.211257.80±260.67796.58±212.71593.33±239.64474.52±112.451189.22±123.22766.57±64.26555.24±93.58
L ACR426.54±118.961132.28±137.42771.2±75.36590.67±106.29493.42±113.021204.54±150.69762.29±68.51541.17±86
R EC421.5±103.191186.76±131.98801.44±49.57608.78±75.25467.90±76.671206.38±142.25785.90±67.27575.67±66.99
L EC473.82±92.651207.59±112.50775.09±67.91558.84±93.05496.03±82.191220.38±150.32766.20±69.01539.11±75.26
R IFOF492.68±71.611265.71±107.18790.68±68.32553.16±80.63518.93±69.641319.51±149.14803.93±64.48546.14±61.75
L IFOF475.18±85.001235.06±108.44786.80±56.69562.67±77.186492.90±88.551305.21±143.83817.78±68.26574.07±80.16
G CC805.78±79.271773.6±231.49799.20±135.38312±138.14792.98±56.111810.47±167.43822.28±72.58328.19±75.54
S CC806.87±83.001862.29±206.96832.26±115.01317.24±143.53845.36±49.031823.75±243.74775.42±113.42251.25±81.05
R FWM383.34±89.301171.85±148.03822.22±66.41647.41±81.58388.92±109.231137.18±106.56798.74±61.26629.51±98.77
L FWM377.06±89.531143.71±126.45810.22±55.30643.47±69.93399.48±116.431147.24±114.15798.29±78.91623.81±114.37
R POWM353.36±76.491155.84±130.45837.16±70.62677.82±70.49394.78±91.191182.94±193.23818.38±108.45636.1±103.87
L POWM344.49±75.641142.25±122.83834.81±74.07681.09±75.55388.00±89.021254.38±148.62871.37±93.75679.86±102.15

[i] ACR = anterior corona radiata; ATR = anterior thalamic radiation; CC = splenium of corpus callosum; EC = external capsule; FM = forceps minor; G CC = genu of corpus callosum; IFOF = inferior fronto occipital fasciculus; ILF = inferior longitudinal fasciculus; L = left; POWM = parieto-occipital white matter; R = right; S CC = superior corpus callosum; S FWM = superior frontal white matter; SLF = superior longitudinal fasciculus

Table 2

Comparison of diffusion tensor imaging (DTI) values of the defined anatomic locations before and after chemotherapy (the significant results are in italics)

Group 1 (n:7)Group 2 (n:18)
Region of interestPre-chemotherapy values (Median (min-max))Post-chemotherapy values (Median (min-max))P valueRegions of interestPre-chemotherapy values (Median (min-max)Post-chemotherapy values (Median (min-max)P value
R ILF FA623 (514–703.3)522 (418.7–679.8)0.028R ILF FA600 (395.3–694.5)593 (336–707)0.89
R FM FA539 (448–591)471 (379.7–615.8)0.31R FM FA525 (454.5–864)487 (322.3–712)0.022
R FM RD487.4 (465.5–605.65)619.4 (439.5–667.85)0.062R FM RD533.275 (201–689)580.35 (367.8–819.15)0.011
R FWM AD1123.5 (912.8–1244)1135.5 (988.3–1265.5)0.39R FWM AD1157.65 (1011.3–1556.5)1104.15 (854.8–1256.3)0.008
R FWM MD786.1 (699.1–871.26)823.26 (658.93–855.1)0.31R FWM MD793.01 (658.2–955.36)812.33(704.53–1006.9)0.029

[i] AD = axial diffusivity; FA = Fractional anisotropy; FM = forceps minor; FWM = frontal white matter; ILF = inferior longitudinal fasciculus; MD = mean diffusivity; R = right; RD = radial diffusivity

Table 3

Comparison of the diffusion tensor imaging (DTI) results of the two chemotherapy regimens on the defined anatomic locations (only the significant results are shown)

Region of interestCisplatinCarboplatinP
Left POWM FA389 (273.3–531)319 (167.3–423)0.034
Left POWM MD767.6 (727.53–925.27)837.13 (737.2–1071.77)0.034
Left POWM RD606.1 (507.9–726.65)705.92 (592.80–905.15)0.029

[i] FA = Fractional anisotropy; MD = mean diffusivity; POWM = parieto-occipital white matter; RD = radial diffusivity

DOI: https://doi.org/10.2478/raon-2022-0017 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
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Language: English
Page range: 150 - 155
Submitted on: Dec 2, 2021
Accepted on: Mar 18, 2022
Published on: May 4, 2022
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
diffusion tensor imaging,
chemotherapy,
carboplatin,
cisplatin,
carcinoma,
non-small-cell lung cancer
Related subjects:
Medicine,
Clinical medicine,
Radiology

© 2022 Sinem Aydin, Tarik Demir, Haci Mehmet Turk, Dilek Hacer Cesme, Altay Aliyev, Mehmet Ali Gultekin, Temel Fatih Yilmaz, Alpay Alkan, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 56 (2022): Issue 2 (June 2022)
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