Figure 1
Figure 2
Figure 3
Output of the multivariate Cox regression model
| Estimates | ||||||
|---|---|---|---|---|---|---|
| Variable | Beta | Standard error | p-value | Hazard ratio exp(Beta) | 95% confidence interval | |
| RD in liver or/and positive lymph nodes (Yes/No) | 1.253 | 0.792 | 0.114 | 0.286 | 0.061 | 1.349 |
| Stage (II/III) | 1.716 | 1.130 | 0.129 | 0.180 | 0.020 | 1.648 |
| Age | 0.027 | 0.033 | 0.415 | 1.028 | 0.962 | 1.097 |
| Days between the two operations | 0.001 | 0.002 | 0.717 | 0.999 | 0.996 | 1.003 |
Characteristics of patients with incidentally detected gallbladder cancer at the time of second surgery and survival characteristics at 1, 3, and 5 years after the intervention
| Characteristics | At second surgery (n = 22) | Time after secondary intervention | ||
|---|---|---|---|---|
| 1 year (n = 17) n (%) | 3 year (n = 12) n (%) | 5 year (n = 9) n (%) | ||
| Age at secondary intervention (years) | ||||
| < 65 | 7 (31.8) | 6 (35.3) | 3 (25.0) | 2 (22.2) |
| 65–75 | 10 (45.5) | 7 (42.2) | 6 (50.0) | 5 (55.6) |
| > 75 | 5 (22.7) | 4 (23.5) | 3 (50.0) | 2 (22.2) |
| Time between the two interventions (days) | ||||
| < 60 | 13 (59.1) | 11 (64.7) | 8 (66.7) | 6 (66.7) |
| > 60 | 9 (40.9) | 6 (35.3) | 4 (33.3) | 3 (33.3) |
| Residual disease in liver | ||||
| No | 15 (68.2) | 13 (76.5) | 12 (100.0) | 9 (100.0) |
| Yes | 7 (31.8) | 4 (23.5) | / | / |
| Positive lymph nodes | ||||
| No | 9 (40.9) | 7 (41.2) | 6 (50.0) | 6 (66.7) |
| Yes | 9 (40.9) | 6 (35.3) | 3 (25.0) | 2 (22.2) |
| No data | 4 (18.2) | 4 (23.5) | 3 (25.0) | 1 (11.1) |
| Secondary surgery | ||||
| 4b,5 segmentectomy + lymphadenectomy | 9 (41.0) | 9 (53.0) | 6 (50.0) | 4 (44.4) |
| 4b,5 segmentectomy + CBD resection | 9 (41.0) | 7 (41.2) | 6 (50.0) | 5 (55.6) |
| ALPPS + CBD resection | 1 (4.5) | / | / | / |
| Extended right hepatectomy + Whipple procedure | 1 (4.5) | 1 (5.8) | / | / |
| 4b,5,6 segmentectomy + resection of CBD, | 1 (4.5) | / | / | / |
| stomach and proximal duodenum | ||||
| CBD resection | 1 (4.5) | / | / | / |
| Stage | ||||
| Stage II | 9 (40.9) | 9 (52.9) | 7 (58.3) | 6 (66.7) |
| Stage III | 13 (59.1) | 8 (47.1) | 5 (41.7) | 3 (33.3) |
| Complications (Clavien-Dindo scale) | ||||
| None | 15 (68.2) | 14 (82.4) | 9 (75.0) | 7 (77.8) |
| Grade I | 1 (4.5) | 1 (5.9) | 1 (4.5) | 1 (11.1) |
| Grade II | 4 (18.3) | 2 (11.8) | 2 (16.7) | 1 (11.1) |
| Grade IVb | 1 (4.5) | / | / | / |
| Grade V | 1 (4.5) | / | / | / |