Study of correlations between CT properties of retrieved cerebral thrombi with treatment outcome of stroke patients

Rebeka Viltuznik; Jernej Vidmar; Andrej Fabjan; Miran Jeromel; Zoran V. Milosevic; Igor J. Kocijancic; Igor Sersa

doi:10.2478/raon-2021-0037

Figures & Tables

Light microscopy images of histological slices along representative retrieved cerebral thrombi. The histological slices were stained by hematoxylin-eosin and then analyzed for the RBS proportion. It can be seen from the images that the structural and compositional diversity among cerebral thrombi is high. All retrieved thrombi had a distinctly heterogeneous, laminated (multilayer) structure which involves the interweaving of compacted erythrocyte-rich (red) regions with thinner (pink) coatings containing a combination of complementary-linked platelets and a fibrin network.

CT image of a patient with stroke (A). In the selected slice, Middle Cerebral Artery (MCA) on both hemispheres of the brain is visible. The occluded MCA section on the right hemisphere and its symmetrical normal MCA section is indicated by a yellow line along the cerebral thrombus. Graphs show Hounsfield Units (HU) value profiles of the CT image along the lines for the occluded (B) and the normal (C) MCA segment.

Graphs of correlation among different data groups. Shown are six graphs of data group pairs from Table 2 that have the highest Pearson coefficients and also statistically most significant linear regression parameters.

Linear regression and Pearson correlation coefficient analysis of data group pairs with statistically most significant correlations and linear regression parameters

Data group pair		Linear regression y = k· x + n			Pearson coefficient

x-values	y-values	k	p-value	R²	ρ
HU avg occl	mRS end	0.227 ± 0.086	0.015	0.233	0.483
HU avg occl	# passes	0.119 ± 0.052	0.031	0.186	0.432
HU avg occl	mRS diff	-0.140 ± 0.067	0.049	0.158	-0.398
HU avg diff	RBC [%]	1.646 ± 0.809	0.053	0.153	0.391
HU avg occl	mRS start	0.087 ± 0.045	0.065	0.140	0.374
HU avg diff	mRS diff	-0.104 ± 0.059	0.093	0.118	-0.343

Experimental data of patients qualified for the study, which include CT, histological, clinical and procedure parameters

	CT parameters									Histology	Clinical parameters								Procedure parameters
#	HU avg				HU var						Stroke etiology	Therapy before stoke	NIHSS			mRS			Procedure parameters
	occl	nor	diff	diff [%]	occl	nor	diff	diff [%]	L [mm]	RBC [%]	Stroke etiology	Therapy before stoke	strt	end	diff	strt	end	diff	Rd [min]	# pass
1.	29.1	32.4	-3.3	-11.4	4.20	4.42	-0.22	-5.0	20.8	11.5	AT	/	21	1	20	4	1	3	42	1
2.	42.0	29.2	12.8	30.5	4.58	8.98	-4.40	-96.3	16.3	45.1	CE	/	17	8	9	5	4	1	62	2
3.	38.5	35.1	3.4	8.9	3.56	2.75	0.80	22.6	17.0	12.0	CE	/	23	7	16	4	3	1	65	1
4.	36.9	34.3	2.5	6.8	11.66	4.58	7.08	60.7	17.5	41.4	CE	AA	18	3	15	5	2	3	77	1
5.	43.7	44.2	-0.5	-1.2	3.55	3.86	-0.31	-8.7	17.9	65.9	AT	/	26	6	20	5	3	2	97	3
6.	35.8	30.0	5.9	16.4	4.17	2.23	1.95	46.7	16.3	61.0	CE	/	7	0	7	3	0	3	38	3
7.	31.8	36.0	-4.2	-13.2	2.77	3.26	-0.49	-17.8	22.2	57.3	AT	/	13	3	10	4	1	3	90	1
8.	37.8	38.9	-1.1	-2.9	2.82	4.45	-1.63	-58.0	26.9	50.3	CE	/	14	3	11	4	3	1	77	1
9.	32.0	24.0	8.1	25.1	9.50	4.90	4.60	48.4	22.7	56.3	CE	ACAA	5	2	3	3	2	1	115	2
10.	38.5	36.5	2.0	5.1	3.20	2.80	0.40	12.5	19.7	52.4	CE	/	26	42	-16	5	6	-1	82	4
11.	38.3	39.4	-1.1	-2.8	5.49	3.66	1.83	33.4	17.1	19.1	AT	/	12	0	12	3	0	3	60	1
12.	35.7	33.9	1.7	4.9	3.56	5.39	-1.83	-51.2	13.9	31.8	CE	AA	6	3	3	3	1	2	69	1
13.	44.3	31.9	12.3	27.8	4.66	5.11	-0.46	-9.8	22.5	74.7	AT	/	19	12	7	5	4	1	108	2
14.	44.1	37.5	6.6	15.0	2.60	3.92	-1.32	-50.9	19.3	38.9	CE	/	18	20	-2	4	5	-1	63	5
15.	36.0	35.4	0.6	1.6	3.48	2.67	0.81	23.4	17.9	48.8	CE	/	42	42	0	5	6	-1	75	2
16.	38.1	36.4	1.7	4.5	4.16	5.45	-1.30	-31.2	18.6	21.3	AT	/	15	4	11	5	4	1	77	1
17.	42.5	40.7	1.8	4.2	3.11	3.74	-0.63	-20.4	13.5	14.8	CE	AA	14	2	12	5	3	2	53	1
18.	38.7	23.3	15.4	39.8	5.66	4.79	0.87	15.3	19.1	42.4	CE	AC	22	3	19	5	4	1	43	1
19.	34.7	30.9	3.8	11.0	5.61	4.43	1.18	21.1	20.9	37.7	AT	/	3	1	2	1	0	1	60	1
20.	41.2	32.4	8.8	21.4	5.14	4.58	0.56	10.9	19.3	56.0	AT	AC	11	40	-29	4	6	-2	76	3
21.	37.2	28.5	8.7	23.5	3.29	5.27	-1.99	-60.4	29.2	79.1	AT	/	19	10	9	5	5	0	61	1
22.	35.2	32.5	2.6	7.5	3.02	2.79	0.24	7.9	13.6	9.3	CE	/	16	9	7	5	5	0	95	3
23.	41.5	34.5	6.9	16.7	5.14	4.47	0.67	13.0	21.5	80.4	AT	/	16	3	13	4	2	2	65	2
24.	28.9	23.2	5.6	19.5	3.52	4.72	-1.20	-34.1	12.1	57.1	CE	/	13	3	10	4	1	3	55	1
25.	40.2	33.4	6.8	17.0	2.91	4.30	-1.39	-47.8	18.7	46.8	AT	AA	42	42	0	5	6	-1	90	4

Study of correlations between CT properties of retrieved cerebral thrombi with treatment outcome of stroke patients

Figures & Tables

Figure 1

Figure 2

Figure 3

Linear regression and Pearson correlation coefficient analysis of data group pairs with statistically most significant correlations and linear regression parameters

Experimental data of patients qualified for the study, which include CT, histological, clinical and procedure parameters

Paradigm

My account