Figure 1
Coverage probability (CovP) concept: an example case is shown to indicate CovP-internal target volume (ITV) and planning organ at risk volumes (PRVs).
Table 1
Patient characteristics of the study cohort
| Parameter | Mean (min.- max.) | Median | n (%) |
|---|---|---|---|
| Age at treatment (years) | 70 (56–83) | 70 | |
| Duration of radiotherapy (weeks) | 7.9 (7.4–8.7) | 7.9 | |
| Gleason-Score (n, %) | |||
| 6 | 4 (14.3 %) | ||
| 7a (3+4) | 15 (53.6 %) | ||
| 7b (4+3) | 9 (32.1 %) | ||
| cTNM (n, %) | |||
| cT1c | 8 (28.6 %) | ||
| cT2a | 8 (28.6 %) | ||
| cT2b | 3 (10.7 %) | ||
| cT2c | 9 (32.1 %) | ||
| Neoadjuvant ADT (n, %) | 22 (78.6 %) | ||
| Duration of ADT (months, range) | 8.9 (3.0–27.0) | 6.0 | |
| Initial PSA peak in ng/ml (range) | 9.1 (1.9–19.8) | 8.3 | |
| PSA-peak by subgroup | |||
| 0 < x ≤ 5 | 3 (10.7 %) | ||
| 5 < x ≤ 10 | 15 (53.6 %) | ||
| 10 < x ≤ 15 | 8 (28.6 %) | ||
| 15 < x ≤ 20 | 2 (7.1 %) |
Figure 2
Survival outcomes: Kaplan-Meier curves of biochemically no evidence of disease (bNED), overall survival (OS), distant metastasis-free survival (DMFS) and prostate-cancer specific survival (PCSS).
Figure 3
Late genitourinary (GU) toxicity items Radiation Therapy Oncology Group (RTOG) bladder late, common terminology criteria (CTC) urinary frequency and CTC urinary obstruction scored over the follow up (FU) period (left).
Y-axis: percentage of patients reporting the toxicity item. Top X-axis: number n of patients with data available. Lower X-axis: years after radiotherapy. Right column: maximum late toxicity summed up by grade
Figure 4
Late gastrointestinal (GI) toxicity items Radiation Therapy Oncology Group (RTOG) rectum late, common terminology criteria (CTC) proctitis and CTC rectal hemorrhage scored over the follow up (FU) period (left).
Y-axis: percentage of patients reporting the toxicity item. Top X-axis: Number n of patients with data available. Lower X-axis: years after radiotherapy. Right column: maximum late toxicity summed up by grade.