Have a personal or library account? Click to login
Prospective evaluation of probabilistic dose-escalated IMRT in prostate cancer Cover

Prospective evaluation of probabilistic dose-escalated IMRT in prostate cancer

Open Access
|Dec 2020

Figures & Tables

Figure 1

Coverage probability (CovP) concept: an example case is shown to indicate CovP-internal target volume (ITV) and planning organ at risk volumes (PRVs).
Coverage probability (CovP) concept: an example case is shown to indicate CovP-internal target volume (ITV) and planning organ at risk volumes (PRVs).

Figure 2

Survival outcomes: Kaplan-Meier curves of biochemically no evidence of disease (bNED), overall survival (OS), distant metastasis-free survival (DMFS) and prostate-cancer specific survival (PCSS).
Survival outcomes: Kaplan-Meier curves of biochemically no evidence of disease (bNED), overall survival (OS), distant metastasis-free survival (DMFS) and prostate-cancer specific survival (PCSS).

Figure 3

Late genitourinary (GU) toxicity items Radiation Therapy Oncology Group (RTOG) bladder late, common terminology criteria (CTC) urinary frequency and CTC urinary obstruction scored over the follow up (FU) period (left).Y-axis: percentage of patients reporting the toxicity item. Top X-axis: number n of patients with data available. Lower X-axis: years after radiotherapy. Right column: maximum late toxicity summed up by grade
Late genitourinary (GU) toxicity items Radiation Therapy Oncology Group (RTOG) bladder late, common terminology criteria (CTC) urinary frequency and CTC urinary obstruction scored over the follow up (FU) period (left).Y-axis: percentage of patients reporting the toxicity item. Top X-axis: number n of patients with data available. Lower X-axis: years after radiotherapy. Right column: maximum late toxicity summed up by grade

Figure 4

Late gastrointestinal (GI) toxicity items Radiation Therapy Oncology Group (RTOG) rectum late, common terminology criteria (CTC) proctitis and CTC rectal hemorrhage scored over the follow up (FU) period (left).Y-axis: percentage of patients reporting the toxicity item. Top X-axis: Number n of patients with data available. Lower X-axis: years after radiotherapy. Right column: maximum late toxicity summed up by grade.
Late gastrointestinal (GI) toxicity items Radiation Therapy Oncology Group (RTOG) rectum late, common terminology criteria (CTC) proctitis and CTC rectal hemorrhage scored over the follow up (FU) period (left).Y-axis: percentage of patients reporting the toxicity item. Top X-axis: Number n of patients with data available. Lower X-axis: years after radiotherapy. Right column: maximum late toxicity summed up by grade.

Patient characteristics of the study cohort

ParameterMean (min.- max.)Mediann (%)
Age at treatment (years)70 (56–83)70
Duration of radiotherapy (weeks)7.9 (7.4–8.7)7.9
Gleason-Score (n, %)
             64 (14.3 %)
             7a (3+4)15 (53.6 %)
             7b (4+3)9 (32.1 %)
cTNM (n, %)
             cT1c8 (28.6 %)
             cT2a8 (28.6 %)
             cT2b3 (10.7 %)
             cT2c9 (32.1 %)
Neoadjuvant ADT (n, %)22 (78.6 %)
             Duration of ADT (months, range)8.9 (3.0–27.0)6.0
             Initial PSA peak in ng/ml (range)9.1 (1.9–19.8)8.3
PSA-peak by subgroup
             0 < x ≤ 53 (10.7 %)
             5 < x ≤ 1015 (53.6 %)
             10 < x ≤ 158 (28.6 %)
             15 < x ≤ 202 (7.1 %)
DOI: https://doi.org/10.2478/raon-2020-0075 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 88 - 96
Submitted on: Aug 31, 2020
|
Accepted on: Nov 2, 2020
|
Published on: Dec 22, 2020
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2020 Daniel Wegener, Bernhard Berger, Zhoulika Outtagarts, Daniel Zips, Frank Paulsen, Martin Bleif, Daniela Thorwarth, Markus Alber, Oliver Dohm, Arndt-Christian Müller, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.