Figure 1
Figure 2
Specificity, sensitivity and positive and negative predictive value of noninvasive urinary tests for the prediction of positive cystoscopic findings
| Test | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|
| XBC, LDATC 0.4923 | 75.0% | 95.2% | 81,8% | 93.0% |
| XBC, LDATC 0.5 | 66.7% | 95.2% | 80.0% | 90.9% |
| VUC | 41.7% | 97.6% | 83.3% | 85.4% |
| XBC, LDATC 0.4923 + VUC | 75.0% | 95.2% | 81,8% | 93.0% |
Sensitivity of the XBC and voided urinary cytology stratified by tumour stage and grade_ Number of cases detected by noninvasive test against number of cases detected by hystology analysis is shown in the parenthsis
| Test / Stage | CIS | Ta | T1 | T2 | Grade | PUNLMP | low grade | high grade |
|---|---|---|---|---|---|---|---|---|
| XBC, LDATC 0.4923 | 100% | 80.0% | 100% | 100% | 0.0% | 66.7% | 100.0% | |
| VUC | 50.0% | 40.0% | 50.0% | 100% | 0.0% | 66.7% | 42.9% |
Summary of the patients’ demographics and test results numbers
| Gender | Number of patients | Mean age, years ± SD |
|---|---|---|
| All | 54 (100.0%) | 70.5 ± 8.8 |
| Male | 42 (77.8%) | 70.5 ± 8.7 |
| Female | 12 (22.2%) | 70.5 ± 9.6 |
| Noninvasive test / standard invasive diagnostic procedure | Number of patients with TP / FN / TN / FP noninvasive test result | |
| XBC / cystocopy (LDATC 0.4923) | 9 / 3 / 40 / 2 | |
| XBC / cystocopy (LDATC 0.5) | 8 / 4 / 40 / 2 | |
| VUC / cystoscopy | 5 / 7 / 41 / 1 | |
| XBC / histology (LDATC 0.4923) | 10 / 3 / 40 / 1 | |
| XBC / histology (LDATC 0.5) | 9 / 4 / 40 / 1 | |
| VUC / histology | 5 / 8 / 40 / 1 | |
Specificity, sensitivity and positive and negative predictive value of noninvasive urinary tests for the prediction of positive histological results
| Test | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|
| XBC, LDATC 0.4923 | 76.9% | 97.5% | 90,9% | 93.0% |
| XBC, LDATC 0.5 | 69.2% | 97.5% | 90.0% | 90.9% |
| VUC | 38.4% | 97.5% | 83.3% | 83.3% |
| XBC, LDATC 0.4923 + VUC | 76.9% | 97.5% | 90,9% | 93.0% |