Radiological evaluation of ex novo high grade glioma: velocity of diametric expansion and acceleration time study Cover

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Radiological evaluation of ex novo high grade glioma: velocity of diametric expansion and acceleration time study

Radiology and Oncology

Volume 55 (2021): Issue 1 (March 2021)

By: Roberto Altieri, Francesco Certo, Giuseppe La Rocca, Antonio Melcarne, Diego Garbossa, Alberto Bianchi, Salvatore Crimi, Alessandro Pluchino, Simone Peschillo and Giuseppe M.V. Barbagallo

Open Access

|Dec 2020

Figures & Tables

MRI scans in Patient 2 at 0 (A), 18 (B) and 54 (C) days. (T1 with gadolinium sequences).

MRI scans in Patient 3 at 0 (A), 465 (B), 742 (C), 790 (D), 811 (E), 825 (F) and 854 (G) days (fluid attenuated inversion recovery [FLAIR] and T1 with gadolinium sequences).

MRI scans in Patient 4 at 0 (A), 160 (B), 196 (C) and 223 (D) days (fluid attenuated inversion recovery [FLAIR] and T1 with gadolinium sequences).

Velocity of diameter expansion (VDE) variation of mean tumor diameter (MTD) for fluid attenuated inversion recovery [FLAIR] and enhancing nodule (EN) volumes for each patient. Plus the case reported by Mandonnet et al. as specified in Discussion paragraph. Graphic shows variation of acceleration (Acc) based on VDE (mm/days2) for FLAIR tumor volume and EN volume along time. Except obvious similar variation for two types of volume considered, peaks are easily notable. VDE of patient #1 is covered by patient #4.

Raw data about velocity of diameter expansion (VDE) of fluid attenuated inversion recovery (FLAIR) and enhancing nodule (EN) volume_ Mean percentage maximal VDE/mean VDE ratio could help in early high grade gliomas (HGG) diagnosis

Interval of consecutive MRI	VDE Pt #1 FLAIR	VDE Pt #2 FLAIR	VDE Pt #2 EN	VDE Pt #3 FLAIR	VDE Pt #3 EN	VDE Pt #4 FLAIR	VDE Pt #4 EN	Mean Values
1	35.50	169.23	311.81	16.68	0.00	11.93	16.81
2	17.03	258.82	104.54	6.66	0.00	0.00	10.81
3	32.24	-52.97	-94.91	43.39	64.14	0.00	0.00
4				64.59	47.84
5				155.18	165.74
6				0.00	48.53
Mean Values	28.26	125.03	107.15	47.75	54.37	3.98	9.21
FLAIR VDE Peak/ VDE mean value ratio (percentage)	125.63	135.36		324.99		300.00		221.49
EN VDE Peak/ VDE mean value ratio (percentage)			291.02		304.81		182.57	259.47
Mean Values								240.48

Data on fluid attenuated inversion recovery (FLAIR) tumor and enhancing nodule (EN) volume velocity of diameter expansion (VDE)_ Reported as mm/year

Data about patient #1, #2, #3, #4

Raw data of mean acceleration (Acc) based on velocity of diameter expansion (VDE) of fluid attenuated inversion recovery (FLAIR) and enhancing nodule (EN) volume_ Mean percentage maximal Acc/mean Acc ratio of each patient could help in early high grade gliomas (HGG) diagnosis

Interval of consecutive MRI	Acc Pt #1 FLAIR	Acc Pt #2 FLAIR	Acc Pt #2 EN	Acc Pt #3 FLAIR	Acc Pt #3 EN	Acc Pt #4 FLAIR	Acc Pt #4 EN	Mean Values
1	0.0003	0.0662	0.1220	0.00010	0	0.0002	0.0003
2	0.0005	0.0394	0.0159	0.00007	0	0.0000	0.0008
3	0.0015	-0.0040	-0.0072	0.00248	0.0037	0.0000	0.0000
4				0.00843	0.0062
5				0.03037	0.0324
6				0.00000	0.0046
Mean Values	0.0008	0.0339	0.0436	0.0069	0.0078	0.0001	0.0004
FLAIR Acc Peak/ Acc mean value ratio (percentage)	195.6695	195.5808		439.7477		300		282.7495
EN Acc Peak/ Acc mean value ratio (percentage)			280.0617		414.7516		77.74935	257.5209
Mean Values								270.1352

DOI: https://doi.org/10.2478/raon-2020-0071 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099

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Language: English

Page range: 26 - 34

Submitted on: Jul 15, 2020

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Accepted on: Oct 16, 2020

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Published on: Dec 3, 2020

Published by: Association of Radiology and Oncology

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

acceleration time,

anaplastic astrocytoma,

high grade glioma,

radiological growth,

velocity of diametric expansion

Related subjects:

Clinical medicine,

Internal medicine,

Haematology, oncology,

© 2020 Roberto Altieri, Francesco Certo, Giuseppe La Rocca, Antonio Melcarne, Diego Garbossa, Alberto Bianchi, Salvatore Crimi, Alessandro Pluchino, Simone Peschillo, Giuseppe M.V. Barbagallo, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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