Figure 1
Figure 2
![MRI scans in Patient 3 at 0 (A), 465 (B), 742 (C), 790 (D), 811 (E), 825 (F) and 854 (G) days (fluid attenuated inversion recovery [FLAIR] and T1 with gadolinium sequences).](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647355e34e662f30ba53aa6c/j_raon-2020-0071_fig_002.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251206%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251206T211452Z&X-Amz-Expires=3600&X-Amz-Signature=a19dac39c034a08062fc5d79b1b8073a7e2caf28ac86ccc52c567800c1e11be9&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
Figure 3
![MRI scans in Patient 4 at 0 (A), 160 (B), 196 (C) and 223 (D) days (fluid attenuated inversion recovery [FLAIR] and T1 with gadolinium sequences).](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647355e34e662f30ba53aa6c/j_raon-2020-0071_fig_003.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251206%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251206T211452Z&X-Amz-Expires=3600&X-Amz-Signature=58b8fca15996e1a2dc4dc49544d9042d94741a640bfdb4774a3ff910664a6f3c&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
Figure 4
![Velocity of diameter expansion (VDE) variation of mean tumor diameter (MTD) for fluid attenuated inversion recovery [FLAIR] and enhancing nodule (EN) volumes for each patient. Plus the case reported by Mandonnet et al. as specified in Discussion paragraph. Graphic shows variation of acceleration (Acc) based on VDE (mm/days2) for FLAIR tumor volume and EN volume along time. Except obvious similar variation for two types of volume considered, peaks are easily notable. VDE of patient #1 is covered by patient #4.](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647355e34e662f30ba53aa6c/j_raon-2020-0071_fig_004.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20251206%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20251206T211452Z&X-Amz-Expires=3600&X-Amz-Signature=56c2d7ffe5b15a93c488d2a169d5e0a15cd416cdf5f83c7d799c07380e928abf&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
Raw data about velocity of diameter expansion (VDE) of fluid attenuated inversion recovery (FLAIR) and enhancing nodule (EN) volume_ Mean percentage maximal VDE/mean VDE ratio could help in early high grade gliomas (HGG) diagnosis
| Interval of consecutive MRI | VDE Pt #1 FLAIR | VDE Pt #2 FLAIR | VDE Pt #2 EN | VDE Pt #3 FLAIR | VDE Pt #3 EN | VDE Pt #4 FLAIR | VDE Pt #4 EN | Mean Values |
|---|---|---|---|---|---|---|---|---|
| 1 | 35.50 | 169.23 | 311.81 | 16.68 | 0.00 | 11.93 | 16.81 | |
| 2 | 17.03 | 258.82 | 104.54 | 6.66 | 0.00 | 0.00 | 10.81 | |
| 3 | 32.24 | -52.97 | -94.91 | 43.39 | 64.14 | 0.00 | 0.00 | |
| 4 | 64.59 | 47.84 | ||||||
| 5 | 155.18 | 165.74 | ||||||
| 6 | 0.00 | 48.53 | ||||||
| Mean Values | 28.26 | 125.03 | 107.15 | 47.75 | 54.37 | 3.98 | 9.21 | |
| FLAIR VDE Peak/ VDE mean value ratio (percentage) | 125.63 | 135.36 | 324.99 | 300.00 | 221.49 | |||
| EN VDE Peak/ VDE mean value ratio (percentage) | 291.02 | 304.81 | 182.57 | 259.47 | ||||
| Mean Values | 240.48 |
Data on fluid attenuated inversion recovery (FLAIR) tumor and enhancing nodule (EN) volume velocity of diameter expansion (VDE)_ Reported as mm/year
Data about patient #1, #2, #3, #4
Raw data of mean acceleration (Acc) based on velocity of diameter expansion (VDE) of fluid attenuated inversion recovery (FLAIR) and enhancing nodule (EN) volume_ Mean percentage maximal Acc/mean Acc ratio of each patient could help in early high grade gliomas (HGG) diagnosis
| Interval of consecutive MRI | Acc Pt #1 FLAIR | Acc Pt #2 FLAIR | Acc Pt #2 EN | Acc Pt #3 FLAIR | Acc Pt #3 EN | Acc Pt #4 FLAIR | Acc Pt #4 EN | Mean Values |
|---|---|---|---|---|---|---|---|---|
| 1 | 0.0003 | 0.0662 | 0.1220 | 0.00010 | 0 | 0.0002 | 0.0003 | |
| 2 | 0.0005 | 0.0394 | 0.0159 | 0.00007 | 0 | 0.0000 | 0.0008 | |
| 3 | 0.0015 | -0.0040 | -0.0072 | 0.00248 | 0.0037 | 0.0000 | 0.0000 | |
| 4 | 0.00843 | 0.0062 | ||||||
| 5 | 0.03037 | 0.0324 | ||||||
| 6 | 0.00000 | 0.0046 | ||||||
| Mean Values | 0.0008 | 0.0339 | 0.0436 | 0.0069 | 0.0078 | 0.0001 | 0.0004 | |
| FLAIR Acc Peak/ Acc mean value ratio (percentage) | 195.6695 | 195.5808 | 439.7477 | 300 | 282.7495 | |||
| EN Acc Peak/ Acc mean value ratio (percentage) | 280.0617 | 414.7516 | 77.74935 | 257.5209 | ||||
| Mean Values | 270.1352 |