The influence of genetic variability in IL1B and MIR146A on the risk of pleural plaques and malignant mesothelioma

Characteristics		Control group N = 175	Pleural plaques N = 394	Malignant mesothelioma N = 277	Test	p
Gender	Male, N (%)	119 (68.0)	271 (68.8)	202 (72.9)	1.757a	0.410
Gender	Female, N (%)	56 (32.0)	123 (31.3)	75 (27.1)
Age	Median (25%–75%)	55.3 (48.6–63.7)	54.9 (48.8–62.7)	66.0 (59.0–73.0)	151.666b	< 0.001
	Low, N (%)	134 (76.6)	278 (71.6) [6]	43 (48.3) [188]	26.891a	< 0.001
Asbestos exposure	Medium, N (%)	13 (7.4)	41 (10.6)	24 (27.0)
	High, N (%)	28 (16.0)	69 (17.8)	22 (24.7)
Smoking	No, N (%)	94 (53.7)	194 (49.4) [1]	150 (55.6) [7]	2.640a	0.267
Smoking	Yes, N (%)	81 (46.3)	199 (50.6)	120 (44.4)

number of missing data is presented in [] brackets

a calculated using Fisher exact test

b calculated using Kruskal-Wallis test

a calculated using Fisher exact test

Table 2

Association between selected polymorphisms and the risk of developing malignant mesothelioma

SNP	Genotype	Controls N (%)	MM N (%)	OR (95% CI)	p	OR (95% CI)_adj1	p_adj1	OR (95% CI)_adj2	p_adj2
IL1B rs1143623	GG	88 (50.3)	152 (54.9)	reference		reference
	GC	67 (38.3)	97 (35.0)	0.84 (0.56–1.26)	0.396	0.82 (0.52–1.29)	0.388	0.56 (0.29–1.05)	0.072
	CC	20 (11.4)	28 (10.1)	0.81 (0.43–1.52)	0.514	0.69 (0.35–1.38)	0.294	0.34 (0.11–1.04)	0.060
	GC+CC	87 (49.7)	125 (45.1)	0.83 (0.57–1.22)	0.341	0.79 (0.52–1.20)	0.266	0.50 (0.28–0.92)	0.025
IL1B rs16944	TT	21 (12.0)	36 (13.0)	1.10 (0.60–2.02)	0.756	0.94 (0.48–1.82)	0.849	0.53 (0.20–1.43)	0.210
	TC	75 (42.9)	118 (42.6)	1.01 (0.67–1.51)	0.960	0.98 (0.63–1.52)	0.911	0.67 (0.36–1.24)	0.198
	CC	79 (45.1)	123 (44.4)	reference		reference
	TC+TT	96 (54.9)	154 (55.6)	1.03 (0.70–1.51)	0.878	0.97 (0.64–1.47)	0.873	0.63 (0.35–1.13)	0.122
IL1B rs1071676	GG	105 (60.0)	165 (59.6)	reference		reference
	GC	60 (34.3)	98 (35.4)	1.04 (0.69–1.56)	0.851	0.97 (0.62–1.51)	0.895	1.00 (0.53–1.89)	0.993
	CC	10 (5.7)	14 (5.1)	0.89 (0.38–2.08)	0.789	0.96 (0.38–2.41)	0.931	2.03 (0.70–5.90)	0.194
	GC+CC	70 (40.0)	112 (40.4)	1.02 (0.69–1.50)	0.927	0.97 (0.64–1.48)	0.885	1.15 (0.64–2.08)	0.632
MIR146A rs2910164	GG	94 (53.7)	158 (57.0)	reference		reference
	GC	64 (36.6)	110 (39.7)	1.02 (0.69–1.53)	0.913	0.91 (0.59–1.41)	0.672	0.67 (0.36–1.25)	0.209
	CC	17 (9.7)	9 (3.2)	0.31 (0.13–0.73)	0.008	0.34 (0.14–0.85)	0.020	0.39 (0.11–1.38)	0.144
	GC+CC	81 (46.3)	119 (43.0)	0.87 (0.60–1.28)	0.488	0.79 (0.52–1.21)	0.278	0.62 (0.34–1.11)	0.109

[i] adj1 = adjustment for age and gender; adj2 = adjustment for age, gender and asbestos exposure; CI = confidence interval; MM = malignant mesothelioma; OR = odds ratio; SNP = single nucleotide polymorphism

Table 3

Association between selected polymorphisms and the risk of developing malignant mesothelioma compared to pleural plaques

SNP	Genotype	Pleural plaques N (%)	MM N (%)	OR (95 % CI)	p	OR (95 % CI)_adj1	p_adj1	OR (95 % CI)_adj2	p_adj2
IL1B rs1143623	GG	205 (52.0)	152 (54.9)	reference		reference
	GC	157 (39.8)	97 (35.0)	0.83 (0.60–1.16)	0.277	0.88 (0.61–1.27)	0.499	0.67 (0.39–1.15)	0.151
	CC	32 (8.1)	28 (10.1)	1.18 (0.68–2.04)	0.554	1.07 (0.58–1.99)	0.827	0.65 (0.22–1.86)	0.418
	GC+CC	189 (48.0)	125 (45.1)	0.89 (0.66–1.21)	0.467	0.92 (0.65–1.29)	0.617	0.67 (0.40–1.11)	0.123
IL1B rs16944	TT	50 (12.7)	36 (13.0)	1.02 (0.63–1.67)	0.923	0.96 (0.56–1.67)	0.897	0.54 (0.22–1.34)	0.184
	TC	169 (42.9)	118 (42.6)	0.99 (0.71–1.38)	0.969	0.98 (0.68–1.42)	0.929	0.70 (0.41–1.19)	0.186
	CC	175 (44.4)	123 (44.4)	reference		reference
	TC+TT	219 (55.6)	154 (55.6)	1.00 (0.73–1.36)	0.998	0.98 (0.69–1.38)	0.905	0.66 (0.40–1.10)	0.110
IL1B rs1071676	GG	233 (59.1)	165 (59.6)	reference		reference
	GC	145 (36.8)	98 (35.4)	0.95 (0.69–1.32)	0.778	0.93 (0.65–1.34)	0.708	0.92 (0.53–1.60)	0.774
	CC	16 (4.1)	14 (5.1)	1.24 (0.59–2.60)	0.578	1.29 (0.56–2.97)	0.553	2.83 (1.04–7.71)	0.042
	GC+CC	161 (40.9)	112 (40.4)	0.98 (0.72–1.34)	0.911	0.97 (0.68–1.37)	0.849	1.09 (0.66–1.82)	0.731
MIR146A rs2910164	GG	196 (49.7)	158 (57.0)	reference		reference
	GC	163 (41.4)	110 (39.7)	0.84 (0.61–1.15)	0.276	0.84 (0.58–1.20)	0.326	0.65 (0.38–1.11)	0.118
	CC	35 (8.9)	9 (3.2)	0.32 (0.15–0.68)	0.003	0.33 (0.15–0.75)	0.008	0.34 (0.11–1.09)	0.069
	GC+CC	198 (50.3)	119 (43.0)	0.75 (0.55–1.02)	0.063	0.74 (0.53–1.05)	0.092	0.59 (0.36–0.99)	0.046

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DOI: https://doi.org/10.2478/raon-2020-0057 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099

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Language: English

Page range: 429 - 436

Submitted on: Jul 7, 2020

Accepted on: Aug 6, 2020

Published on: Oct 21, 2020

Published by: Association of Radiology and Oncology

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

asbestos,

genetic variation,

malignant mesothelioma,

miRNA,

Related subjects:

© 2020 Petra Piber, Neza Vavpetic, Katja Goricar, Vita Dolzan, Viljem Kovac, Alenka Franko, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 54 (2020): Issue 4 (December 2020)