Figure 1
Figure 2
Demographics of sentinel lymph node biopsy (SLNB) group
| Negative SLN | Positive SLN | Unfound SLN | All SLNB | |
|---|---|---|---|---|
| Number of patients | 1837(75.7) | 519 (21.4) | 70 (2.9) | 2426 (100.0) |
| Tumour site | ||||
| Head | 174 (9.5) | 34 (6.6) | 21 (30.0) | 229 (9.4) |
| Neck | 30 (1.6) | 6 (1.2) | 7 (10.0) | 43 (1.8) |
| Trunk | 857 (46.7) | 268 (51.6) | 30 (42.9) | 1155 (47.6) |
| Limbs | 776 (42.2) | 211 (40.7) | 12 (17.1) | 999 (41.2) |
| Breslow thickness (mm) | ||||
| < 1.5 | 757 (41.2) | 67 (12.7) | 24 (32.9) | 848 (34.8) |
| 1.5–3.5 | 735 (40.0) | 226 (43.5) | 26 (37.1) | 987 (40.7) |
| 3.5 | 323 (17.6) | 224 (43.2) | 20 (28.6) | 567 (23.4) |
| Unknown | 20 (1.1) | 3 (0.6) | 1 (1.4) | 24 (1.0) |
| Ulceration | ||||
| Yes | 554 (30.2) | 234 (45.1) | 40 (57.1) | 828 (34.1) |
| No | 1054 (57.4) | 232 (44.7) | 22 (31.4) | 1308 (53.9) |
| Unknown | 229 (12.5) | 53 (10.2) | 8 (11.4) | 290 (12.0) |
| Tumour subtype | ||||
| SSM | 260 (14.2) | 62 (11.9) | 9 (12.9) | 331 (13.6) |
| NM | 277 (15.1) | 129 (24.9) | 10 (14.3) | 416 (17.1) |
| LMM | 14 (0.8) | 1 (0.2) | 1 (1.4) | 16 (0.7) |
| ALM | 29 (1.6) | 10 (1.9) | 0 (0.0) | 39 (1.6) |
| Other | 105 (5.7) | 25 (4.8) | 2 (2.9) | 132 (5.4) |
| Unknown | 1152 (62.7) | 292 (56.3) | 48 (68.6) | 1492 (61.5) |
Demographics of the four groups with lymph node dissection
| CLND | MLNM | SLNM | UPM | p | |
|---|---|---|---|---|---|
| Number of patients | 455 (57.7) | 121 (15.3) | 149 (18.9) | 64 (8.1) | |
| Age (years) | 0.005 | ||||
| Mean | 56 | 60 | 59 | 58 | |
| Median | 56 | 64 | 61 | 61 | |
| Gender | 0.198 | ||||
| F | 206 (45.3) | 63 (52.1) | 65 (43.6) | 23 (36.0) | |
| M | 249 (54.7) | 58 (47.9) | 84 (56.4) | 41 (64.0) | |
| Primary tumour site | 0.254 | ||||
| Head | 29 (6.4) | 16 (13.2) | 25 (16.8) | - | |
| Neck | 5 (1.1) | 4 (3.3) | 2 (1.3) | - | |
| Trunk | 235 (51.6) | 48 (39.7) | 64 (43.0) | - | |
| Limbs | 186 (40.9) | 53 (43.8) | 58 (39.0) | - | |
| Breslow thickness (mm) | < | ||||
| Mean ± SD | 3.9 ± 0.1 | 3.5 ± 0.3 | 8.5 ± 0.8 | - | |
| Median | 3.0 | 2.6 | 6.0 | - | |
| < 1.5 | 60 (13.2) | 28 (23.1) | 12 (8.1) | - | |
| 1.5–3.5 | 202 (44.4) | 54 (44.6) | 21 (14.1) | - | |
| > 3.5 | 190 (41.8) | 35 (28.9) | 105 (70.5) | - | |
| Unknown | 3 (0.7) | 4 (3.3) | 11 (7.4) | - | |
| Clark level | < | ||||
| II | 2 (0.4) | 1 (0.8) | 1 (0.7) | - | |
| III | 87 (19.1) | 32 (26.4) | 16 (10.7) | - | |
| IV | 234 (51.4) | 50 (41.3) | 63 (42.3) | - | |
| V | 41 (9.0) | 7 (5.8) | 33 (22.1) | - | |
| Unknown | 91 (20.0) | 31 (25.6) | 36 (24.2) | - | |
| Ulceration | |||||
| Present | 197 (43.4) | 47 (38.8) | 91 (61.1) | - | < |
| Absent | 213 (46.8) | 52 (43.0) | 18 (12.1) | - | |
| Unknown | 45 (9.9) | 22 (18.2) | 40 (26.8) | - | |
| Number of positive nodes | < | ||||
| Mean ± S.D. | 1.6 ± 1.8 | 3.3 ± 4.0 | 4.3 ± 5.4 | 4.5 ± 7.0 | |
| Median | 1 | 2 | 2 | 2 | |
| Diameter of the largest lymph node metastases (mm) | < | ||||
| Mean ± S.D. | 3.5 ± 5.7 | 35.3 ± 30.7 | 20.8 ± 14.2 | 46.0 ± | |
| Median | 1.4 | 28 | 16 | 47 |