Classification of consensus molecular subtypes (CMS)_ Adopted by Guiney et al_7
| CMS subtype | CMS1 -MSI immune | CMS2 - Canonical | CMS3 – Metabolic | CMS4 - Mesenchymal |
|---|---|---|---|---|
| Frequency | 14% | 37% | 13% | 23% |
| MSI, CIMP high, hypermutation | SCNA high | Mixed MSI CIMP status, low SCNA low, | SCNA high | |
| BRAF mutation | KRAS mutation | |||
| Characteristics | Immune infiltration and activation | WNT and MYC activation | Metabolic deregulation | Stromal infiltration, TGF-β activation, angiogenesis |
| Worse survival after relapse | Worse relapse- free and overall survival |