Effect of radiotherapy on coronary arteries and heart in breast-conserving surgery: a dosimetric analysis

		Right-sided breast cancer n (%)	Left-sided breast cancer n (%)
Breast conservation surgery		20 (100%)	20 (100%)
Age		57.33 ± 10.21 (40–80)	61.35 ± 9.91 (42–76)
T stage	T1	15 (75%)	12 (60%)
T stage	T2	5 (25%)	8 (40%)
N stage	N0	20 (100%)	20 (100%)
M stage	M0	20 (100%)	20 (100%)
Tumor location	inner quadrant	6 (30%)	10 (50%)
Tumor location	outer quadrant	14 (70%)	10 (50%)
Tumor size	≤ 2 cm	15 (75%)	12 (60%)
Tumor size	2–5 cm	5 (25%)	8 (40%)
Chemotherapy	Yes	7 (35%)	11 (55%)
Chemotherapy	No	13 (65%)	9 (45%)
Number of chemotherapy cycles	4	4 (20%)	6 (30%)

	6	3 (15%)	5 (25%)

Table 2

The dosimetric parameters of left anterior descending coronary artery (LAD), left circumflex coronary artery (LCx), right ventricle (RV), left ventricle (LV) and heart depending on the side of the tumor

Dosimetric parameters		Right-sided breast cancer	Left-sided breast cancer	P value
LAD	D_mean	97.57 ± 10.26 (73.8–114)	2402.48 ± 838.39 (1020–3783)	< 0.0001
	D_max	111.87 ± 16.15 (78.8–145)	4752.83 ± 498.46 (3700–5703.8)	< 0.0001
	D_min	83.12 ± 9.31 (63.7–100.1)	222.59 ± 76.42 (95–471)	< 0.0001
LCx	D_mean	84.99 ± 9.09 (63.8–100.8)	170.55 ± 45.36 (85.8–260.2)	< 0.0001
	D_max	96.27 ± 11.33 (75.6–116.3)	203.49 ± 55.9 (112–353.9)	< 0.0001
	D_min	74.59 ± 8.57 (54.5–92.1)	137.63 ± 38.59 (69.7–235.5)	< 0.0001
RV	D_mean	130.18 ± 24.92 (110.8–224.2)	563.65 ± 221.78 (140.9–875.6)	< 0.0001
	D_max	464.76 ± 517.55 (221.2–2619)	4576.55±1077.66 (460.1–6149.3)	< 0.0001
	D_min	75.51 ± 7.81 (58.8–90.5)	103.41 ± 28.67 (49.3–184.9)	< 0.0001
LV	D_mean	81.71 ± 7.9 (60.9–96.5)	536.8 ± 193.24 (230–1018.1)	< 0.0001
	D_max	149.13 ± 43.75 (85.1–264.2)	4822.6 ± 362.4 (3964.4–5835.4)	< 0.0001
	D_min	65.75 ± 7.02 (47.1–80.2)	105.49 ± 26.64 (52.2–184.2)	< 0.0001
Heart	D_mean	120.33 ± 19.05 (97.3 – 189.2)	396.56 ± 131.73 (158.5–588.7)	< 0.0001
Heart	D_max	634.48 ± 751.55 (277–3759.5)	5032.44 ± 331.02 (4134.3–5992.9)	< 0.0001

[i] All values are given as mean + standard deviation (r ange).

LAD = Left anterior descending coronary artery; LCx = left circumflex coronary artery; RV = right ventricle; LV = left ventricle

References

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DOI: https://doi.org/10.2478/raon-2020-0013 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099

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Language: English

Page range: 128 - 134

Submitted on: Dec 4, 2019

Accepted on: Feb 15, 2020

Published on: Mar 7, 2020

Published by: Association of Radiology and Oncology

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

heart,

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© 2020 Gulsen Pinar Soydemir Gocer, Elif Eda Ozer, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 54 (2020): Issue 1 (March 2020)