Have a personal or library account? Click to login
Radiological findings of porcine liver after electrochemotherapy with bleomycin Cover

References

  1. Ong SL, Gravante G, Metcalfe MS, Dennison AR. History, ethics, advantages and limitations of experimental models for hepatic ablation. World J Gastroenterol 2013; 19: 147-54. doi: 10.3748/wjg.v19.i2.147
  2. Au JT, Kingham TP, Jun K, Haddad D, Gholami S, Mojica K, et al. Irreversible electroporation ablation of the liver can be detected with ultrasound B-mode and elastography. Surgery 2013; 153: 787-93. doi: 10.1016/j. surg.2012.11.022
  3. Edhemovic I, Brecelj E, Gasljevic G, Music MM, Gorjup V, Mali B, et al. Intraoperative electrochemotherapy of colorectal liver metastases. J Surg Oncol 2014; 110: 320-7. doi: 10.1002/jso.23625
  4. Edhemovic I, Gadzijev EM, Brecelj E, Miklavcic D, Kos B, Zupanic A, et al. Electrochemotherapy: a new technological approach in treatment of metastases in the liver. Technol Cancer Res Treat 2011; 10: 475-85. doi: 10.7785/ tcrt.2012.500224
  5. Kingham TP, Karkar AM, D’Angelica MI, Allen PJ, DeMatteo RP, Getrajdman GI, et al. Ablation of perivascular hepatic malignant tumors with irreversible electroporation. J Am Coll Surg 2012; 215: 379-87. doi: 10.1016/j.jamcollsurg.2012.04.029
  6. Colletti L, Battaglia V, De Simone P, Turturici L, Bartolozzi C, Filipponi F. Safety and feasibility of electrochemotherapy in patients with unresectable colorectal liver metastases: a pilot study. Int J Surg 2017; 44: 26-32. doi: 10.1016/j.ijsu.2017.06.033
  7. Tafuto S, von Arx C, De Divitiis, Maura CT, Palaia R, Albino V, et al. Electrochemotherapy as a new approach on pancreatic cancer and on liver metastases. Int J Surg 2015; 21: S78-S82. doi: 10.1016/j.ijsu.2015.04.095
  8. Miklavcic D, Mali B, Kos B, Heller R, Sersa G. Electrochemotherapy: from the drawing board into medical practice. Biomed Eng Online 2014; 13: 29. doi: 10.1186/1475-925X-13-29
  9. Campana LG, Clover JG, Valpione S, Quaglino P, Gehl J, Kunte C, et al. Recommendations for improving the quality of reporting clinical electrochemotherapy studies based on qualitative systematic review. Radiol Oncol 2016; 50: 1-13. doi: 10.1515/raon-2016-0006
  10. Campana LG, Marconato R, Valpione S, Galuppo S, Alaibac M, Rossi CR, et al. Basal cell carcinoma: 10-year experience with electrochemotherapy. J Transl Med 2017; 15: 122. doi: 10.1186/s12967-017-1225-5
  11. Djokic M, Cemazar M, Popovic P, Kos B, Dezman R, Bosnjak M, et al. Electrochemotherapy as treatment option for hepatocellular carcinoma, a prospective pilot study. Eur J Surg Oncol 2018; 44: 651-7. doi: 10.1016/j. ejso.2018.01.090
  12. Gasljevic G, Edhemovic I, Cemazar M, Brecelj E, Gadzijev EM, Music MM, et al. Histopathological findings in colorectal liver metastasis after electrochemotherapy. PloS One 2017; 12: e0180709. doi: 10.1371/journal. pone.0180709
  13. Tarantino L, Busto G, Nasto A, Fristachi R, Cacace L, Talamo M, et al. Percutaneous electrochemotherapy in the treatment of portal vein tumor thrombosis at hepatic hilum in patients with hepatocellular carcinoma in cirrhosis: a feasibility study. World J Gastroenterol 2017; 23: 906-18. doi: 10.3748/wjg.v23.i5.906
  14. Granata V, Fusco R, Piccirillo M, Palaia R, Petrillo A, Lastoria S, Izzo F. Electrochemotherapy in locally advanced pancreatic cancer: Preliminary results. Int J Surg 2015; 18: 230-6. doi: 10.1016/j.ijsu.2015.04.055
  15. Bimonte S, Leongito M, Granata V, Barbieri A, del Vecchio V, Falco M, et al. Electrochemotherapy in pancreatic adenocarcinoma treatment: preclinical and clinical studies. Radiol Oncol 2016; 50: 14-20. doi: 10.1515/ raon-2016-0003
  16. Granata V, Fusco R, Setola SV, Palaia R, Albino V, Piccirillo M, et al. Diffusion kurtosis imaging and conventional diffusion weighted imaging to assess electrochemotherapy response in locally advanced pancreatic cancer. Radiol Oncol 2019; 53: 15-24. doi: 10.2478/raon-2019-0004
  17. Cannon R, Ellis S, Hayes D, Narayanan G, Martin RCG. Safety and early efficacy of irreversible electroporation for hepatic tumors in proximity to vital structures. J Surg Oncol 2013; 107: 544-9. doi: 10.1002/jso.23280
  18. Lee EW, Chen C, Prieto VE, Dry SM, Loh CT, Kee ST. Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation. Radiology 2010; 255: 426-33. doi: 10.1148/radiol.10090337
  19. Lee YJ, Lu DS, Osuagwu F, Lassman C. Irreversible electroporation in porcine liver: short- and long-term effect on the hepatic veins and adjacent tissue by CT with pathological correlation. Invest Radiol 2012; 47: 671-5. doi: 10.1097/RLI.0b013e318274b0df
  20. Narayanan G, Bhatia S, Echenique A, Suthar R, Barbery K, Yrizarry J. Vessel patency post irreversible electroporation. Cardiovasc Intervent Radiol 2014; 37: 1523-9. doi: 10.1007/s00270-014-0988-9
  21. Kasivisvanathan V, Thapar A, Oskrochi Y, Picard J, Leen EL. Irreversible electroporation for focal ablation at the porta hepatis. Cardiovasc Intervent Radiol 2012; 35: 1531-4. doi: 10.1007/s00270-012-0363–7
  22. Lee YJ, Lu DS, Osuagwu F, Lassman C. Irreversible electroporation in porcine liver: acute computed tomography appearance of ablation zone with histopathologic correlation. J Comput Assist Tomogr 2013; 37: 154-8. doi: 10.1097/RCT.0b013e31827dbf9b
  23. Appelbaum L, Ben-David E, Sosna J, Nissenbaum Y, Goldberg SN. US findings after irreversible electroporation ablation: radiologic-pathologic correlation. Radiology 2012; 262: 117-25. doi: 10.1148/radiol.11110475
  24. Abdelsalam ME, Chetta JA, Harmoush S, Ensor J Jr, Javadi S, Dixon K, et al. CT findings after irreversible electroporation ablation in a porcine model: radiologic-pathologic correlation. J Vasc Interv Radiol 2013; 24: S161. doi: 10.1016/j.jvir.2013.01.405
  25. Charpentier KP, Wolf F, Noble L, Winn B, Resnick M, Dupuy DE. Irreversible electroporation of the liver and liver hilum in swine. HPB (Oxford) 2011; 13: 168-73. doi: 10.1111/j.1477-2574.2010.00261.x
  26. Chung DJ, Sung K, Osuagwu FC, Wu HH, Lassman C, Lu DS. Contrast enhancement patterns after irreversible electroporation: experimental study of CT perfusion correlated to histopathology in healthy porcine liver. J Vasc Interv Radiol 2016; 27: 104-11. doi: 10.1016/j.jvir.2015.09.005
  27. Boc N, Edhemovic I, Kos B, Music MM, Brecelj E, Trotovsek B, et al. Ultrasonographic changes in the liver tumors as indicators of adequate tumor coverage with electric field for effective electrochemotherapy. Radiol Oncol 2018; 52: 383-91. doi: 10.2478/raon-2018-0041
  28. Zmuc J, Gasljevic G, Sersa G, Edhemovic I, Boc N, Seliskar A, et al. Large liver blood vessels and bile ducts are not damaged by electrochemotherapy with bleomycin in pigs. Sci Rep 2019: 9: 3649. doi: 10.1038/s41598-019-40395-y
  29. Kos B, Voigt P, Miklavcic D, Moche M. Careful treatment planning enables safe ablation of liver tumors adjacent to major blood vessels by percutaneous irreversible electroporation (IRE). Radiol Oncol 2015; 49: 234-41. doi: 10.1515/raon-2015-0031
  30. Marčan M, Pavliha D, Kos B, Forjanič T, Miklavčič D. Web-based tool for visualization of electric field distribution in deep-seated body structures and planning of electroporation-based treatments. Biomed Eng Online 2015; 14 Suppl 3: S4. doi: 10.1186/1475-925X-14-S3-S4
  31. Marty M, Sersa G, Rémi Garbay J, Gehl J, Collins CG, Snoj M, et al. Electrochemotherapy – an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. EJC Supplements 2006; 4: 3-13. doi: 10.1016/j.ejcsup.2006.08.002
  32. Mir LM, Gehl J, Sersa G, Collins CG, Garbay JR, Billard V, et al. Standard operating procedures of the electrochemotherapy: instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by Cliniporator by means of invasive or noninvasive electrodes. Eur J Cancer Suppl 2006; 4: 14-25. doi: 10.1016/j. ejcsup.2006.08.003
  33. Nykonenko A, Vavra P, Zonca P. Anatomic peculiarities of pig and human liver. Exp Clin Transplant 2017; 15: 21–6.
  34. Bellard E, Markelc B, Pelofy S, Le Guerroué, Sersa G, et al. Intravital microscopy at the single vessel level brings new insights of vascular modification mechanisms induced by electropermeabilization J Control Release 2012; 163: 396-403. doi: 10.1016/j.jconrel.2012.09.010
  35. Jarm T, Cemazar M, Miklavcic D, Sersa G. Antivascular effects of electrochemotherapy: implications in treatment of bleeding metastases. Expert Rev Anticancer Ther 2010; 10: 729–46. doi: 10.1586/era.10.43
  36. Gehl J, Skovsgaard T, Mir LM. Vascular reactions to in vivo electroporation: characterization and consequences for drug and gene delivery. Biochim Biophys Acta 2002; 1569: 51-8.
  37. Markelc B, Bellard E, Sersa G, Jesenko T, Pelofy S, Teissié, et al. Increased permeability of blood vessels after reversible electroporation is facilitated by alterations in endothelial cell-to-cell junctions. J Control Release 2018; 276: 30-41. doi: 10.1016/j.jconrel.2018.02.032
  38. Ivanusa T, Beravs K, Cemazar M, Jevtic V, Demsar F, Sersa G. MRI macromolecular contrast agents as indicators of changed tumor blood flow. Radiol Oncol 2001; 35: 139-47.
  39. Sersa G, Cemazar M, Miklavcic D. Tumor blood flow modifying effects of electrochemotherapy: a potential vascular targeted mechanism. Radiol Oncol 2003; 37: 43-8.
  40. Sersa G, Cemazar M, Miklavcic D, Chaplin DJ. Tumor blood flow modifying effect of electrochemotherapy with bleomycin. Anticancer Res 1999; 19: 4017-22.
  41. Sersa G, Cemazar M, Parkins CS, Chaplin DJ. Tumour blood flow changes induced by application of electric pulses. Eur J Cancer 1999; 35: 672-7.
  42. Li K, Xin Y, Gu Y, Xu B, Fan D, Ni B. Effects of direct current on dog liver: Possible mechanisms for tumor electrochemical treatment. Bioelectromagnetics 1997; 18: 2-7.
  43. Stehling MK, Guenther E, Mikus P, Klein N, Rubinsky L, Rubinsky B. Synergistic combination of electrolysis and electroporation for tissue ablation. PloS One 2016; 11: e0148317. doi: 10.1371/journal.pone.0148317
  44. Oei T, vanSonnenberg E, Shankar S, Morrison PR, Tuncali K, Silverman SG. Radiofrequency ablation of liver tumors: a new cause of benign portal venous gas. Radiology 2005; 237: 709-17.
  45. Faroja M, Ahmed M, Appelbaum L, Ben-David E, Moussa M, Sosna J. Irreversible electroporation ablation: is all the damage non thermal? Radiology 2013; 266: 462-70. doi: 10.1148/radiol.12120609
  46. Miklavcic D, Semrov D, Mekid H, Mir LM. A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy. Biochim Biophys Acta 2000; 1523: 73-83.
  47. Miklavcic D, Sersa G, Brecelj E, Gehl J, Soden D, Bianchi G, et al. Electrochemotherapy: technological advancements for efficient electroporation-based treatment of internal tumors. Med Biol Eng Comput 2012; 50: 1213-25. doi: 10.1007/s11517-012-0991-8
DOI: https://doi.org/10.2478/raon-2019-0049 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 415 - 426
Submitted on: Aug 15, 2019
|
Accepted on: Sep 12, 2019
|
Published on: Oct 10, 2019
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2019 Maja Brloznik, Nina Boc, Gregor Sersa, Jan Zmuc, Gorana Gasljevic, Alenka Seliskar, Rok Dezman, Ibrahim Edhemovic, Nina Milevoj, Tanja Plavec, Vladimira Erjavec, Darja Pavlin, Masa Bosnjak, Erik Brecelj, Ursa Lampreht Tratar, Bor Kos, Jani Izlakar, Marina Stukelj, Damijan Miklavcic, Maja Cemazar, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.