Figure 1
Acute toxicity during TNT
| Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | N | % | ||
| Thrombocytopenia | 4 | 6.1 | 4 | 6.1 | |||||
| Anemia | 8 | 12.1 | 2 | 3.0 | |||||
| Neutropenia | 1 | 1.5 | 3 | 4.5 | |||||
| During ChT | Diarrhea | 4 | 6.1 | 3 | 4.5 | ||||
| Nausea | 21 | 31.8 | 1 | 1.5 | |||||
| Vomiting | 4 | 6.1 | 1 | 1.5 | |||||
| Hand-foot syndrome | 7 | 10.6 | 1 | 1.5 | 1 | 1.5 | |||
| Parasthesia | 36 | 54.5 | 1 | 1.5 | |||||
| Thrombocytopenia | 9 | 13.6 | 2 | 3.0 | |||||
| Anemia | 5 | 7.6 | 3 | 4.5 | |||||
| Neutropenia | 2 | 3.0 | 3 | 4.5 | |||||
| Diarrhea | 22 | 33.3 | 4 | 6.1 | 1 | 1.5 | |||
| During CRT | Nausea | 7 | 10.6 | ||||||
| Cystitis | 22 | 33.3 | 3 | 4.5 | |||||
| Proctitis | 8 | 12.1 | 3 | 4.5 | |||||
| Dermatitis | 5 | 7.6 | 5 | 7.6 | 2 | 3.0 | |||
| Hand-foot syndrome | 5 | 7.6 | 3 | 4.5 | |||||
Distribution of the initial clinical and pathologic stage, (N = 60)
| Clinical stage | Pathological stage | |||||||
|---|---|---|---|---|---|---|---|---|
| pT0 | pT1 | pT2 | pT3 | pT4 | pN0 | pN1 | pN2 | |
| cT2 | 1 | / | / | / | / | |||
| cT3 | 7 | 5 | 6 | 17 | 1 | |||
| cT4 | 6 | 0 | 6 | 8 | 3 | |||
| cN1 | 17 | 1 | / | |||||
| cN2 | 33 | 8 | 1 | |||||
Patient’s demographic and baseline clinical characteristics (N = 66)
| Characteristic | No. (66) | % |
|---|---|---|
| Gender | ||
| Male | 41 | 62.1 |
| Female | 25 | 37.9 |
| Age, years | ||
| Median, range | 59, 33–74 | |
| ECOG performance status | ||
| 0 | 50 | 75.8 |
| 1 | 16 | 24.2 |
| Distance from the anal verge | ||
| < 5 cm | 25 | 37.9 |
| 5–10 cm | 30 | 45.4 |
| >10 cm | 11 | 16.7 |
| High risk factors | ||
| cT4 | 24 | 36.4 |
| EMVI+ | 46 | 69.7 |
| Positive extramesorectal lgl | 3 | 4.5 |
| MRF+ | 47 | 71.2 |
| cTN stage | ||
| T2N2 | 1 | 1.5 |
| T3N1 | 17 | 25.8 |
| T3N2 | 24 | 36.4 |
| T4N1 | 3 | 4.5 |
| T4N2 | 21 | 31.8 |