Table 1
Baseline clinical, radiological and pathological characteristics of patients with early-stage non-small cell lung cancer and idiopathic interstitial pneumonia
| Characteristics | N = 13 (%) | |
|---|---|---|
| Gender | Male | 11 (84.6) |
| Female | 2 (15.4) | |
| Age, years | 73.3 ± 4 | |
| Current smoker | 3 (23.1) | |
| Smoking status | Former-smoker | 8 (61.5) |
| Never-smoker | 2 (15.4) | |
| FEV1/FVC before operation | 0.71 ± 0.08 | |
| FEV1 before operation | ml % | 2769 ± 690 101.6 ± 20 |
| FVC before operation | ml % | 3910 ± 818 105 ±19 |
| DLCO before operation | % | 74.2 ±21 |
| Squamous cell carcinoma | 7 (53.8) | |
| Histological subtype | Adenocarcinoma | 5 (38.5) |
| Adenosquamous cell carcinoma | 1 (7.7) | |
| pT1a | 3 (23.0) | |
| pT2a | 6 (46.2) | |
| pT2b | 4 (30.8) | |
| Pathologic TNM stage | IA | 2 (15.4) |
| (8th edition) | IB | 2 (15.4) |
| IIA | 3 (23.0) | |
| IIB | 4 (30.8) | |
| IIIA | 2 (15.4) | |
| Left lower lobe | 7 (53.8) | |
| Lobe distribution | Right lower lobe | 4 (30.8) |
| Right middle lobe | 2 (15.4) | |
| Type of operation | Lobectomy Bilobectomy | 11 (84.6) 2 (15.4) |
| Adjuvant chemotherapy | 4 (30.8) | |
| Adjuvant therapy | Adjuvant radiotherapy | 1 (7.7) |
[i] Data are presented by mean ± SD or number (N, %).
DLCO = diffusing capacity of the lung for carbon monoxide; FEV1 = forced expiratory volume in 1 s; FVC = forced vital capacity
Figure 1
Radiological images and images of pathological specimens for Patient No.1. (A) CT scan before lung resection demonstrating honeycomb cystic changes in the subpleural regions of the lung characteristic for typical UIP pattern and tumor in left lower lobe. (B) CT scan after (radical treatment) lobectomy showing extensive bilateral ground glass opacities which are consistant with acute exacerbation of UIP and progressive reticular fibrotic changes. (C) Surgical specimen showing subpleural honeycombing with fibroblastic focus. (D) Autopsy specimen showing acute lung injury with hyaline membranes.
Figure 2
Radiological images and images of pathological specimens for Patient No.2. (A) Chest X ray before surgical resection shows some reticular changes in the periphery of the lower lobes. CT shows reticular fibrotic changes with multiple calcifications in the periphery of the lung in combination with paraseptal emphsema and small tumor in the left lower lobe. (B) Chest X ray after left sided lobectomy shows new bilateral alveolar opacities. (C) Surgical resection specimen demonstrating microcystic changes with fibroblastic focus. (D) Autopsy specimen showing acute lung injury with hyaline membranes
Table 2
Baseline clinical, radiological and pathological characteristics of the two patients who died in two months time after radical treatment of early-stage non-small cell lung cancer due to acute exacerbation of idiopathic pulmonary fibrosis (IPF)
| Characteristics | Patient No. 1 | Patient No. 2 |
|---|---|---|
| Gender | Male | Male |
| Age, years | 73 | 81 |
| Smoking status | Former-smoker | Former-smoker |
| FEV1/FVC before operation | 72% | 70% |
| FEV1 before operation | 2800 ml (93%) | 3110 ml (121%) |
| FVC before operation | 3900 ml (94%) | 4570 ml (122%) |
| DLCO before operation | 57% | 47% |
| Histological subtype | Squamous cell carcinoma | Squamous cell carcinoma |
| Pathologic TNM stage (8th edition) | IIIA | IA |
| Lobe distribution | Left lower lobe | Left lower lobe |
| Type of operation | Lobectomy | Lobectomy |
| Adjuvant therapy | Chemotherapy and radiotherapy | No |
| Time from the end of radical treatment till death | 54 days after finishing radiotherapy | 14 days after surgical resection |
[i] DLCO = diffusing capacity of the lung for carbon monoxide; FEV1 = forced expiratory volume in 1 s; FVC = forced vital capacity