Table 1
Clinical data and outcome of 91 patients with pT4 tumor stage
| Characteristic | Subgroup | Number of patients |
|---|---|---|
| Gender | Female | 44 |
| Male | 47 | |
| Patient’s age | 44 or less | 15 |
| 45 or more | 76 | |
| Tumor diameter (cm) | 1-9 | 75 |
| 9.1-30 | 16 | |
| T stage | pT4a | 63 |
| pT4b | 28 | |
| Lymph nodes metastases | No | 53 |
| Yes | 38 | |
| Distant metastases | No | 68 |
| Yes | 23 | |
| Residual tumor after surgery | R0 | 27 |
| R1 | 47 | |
| R2 | 5 | |
| No surgery | 12 | |
| Recurrence | No | 39 |
| Yes-distant | 13 | |
| Yes-locoregional | 16 | |
| Disease present permanently | 23 | |
| Outcome | Alive | 44 |
| Dead of distant disease | 29 | |
| Dead of local disease | 1 | |
| Dead of local and distant disease | 4 | |
| Dead of other causes | 10 | |
| Lost from follow-up | 3 |
Table 2
Treatment of patients
| Characteristic | Subgroup | Number of Patients |
|---|---|---|
| Surgery of the thyroid | Lobectomy or less | 15 |
| Total or near-total thyroidectomy | 64 | |
| Without surgery | 12 | |
| Neck dissection | No | 64 |
| Yes | 27 | |
| Radioiodine ablation | No | 9 |
| Yes | 82 | |
| Therapy with radioiodine | No | 54 |
| Yes | 37 | |
| Radiotherapy-Neck region | No | 0 |
| Yes | 91 | |
| Chemotherapy | No | 52 |
| Yes | 39 | |
| Tyrosine kinase inhibitors | No | 89 |
| Yes | 2 |
Figure 1
Disease-specific survival according to T4a and T4b tumor stage (p = 0.07) (bold line, T4b; dotted line, T4a).
Figure 2
Overall survival according to T4a and T4b tumor stage (p = 0.08) (bold line, T4b; dotted line, T4a).
Figure 3
Disease-free survival according to T4a and T4b tumor stage in 64 patients without persistent disease (p = 0.122) (bold line, T4b; dotted line, T4a).
Figure 4
Patients without distant metastases had longer disease-specific survival than those without distant metastases (p < 0.001) (bold line, with metastases; dotted line, without metastases).