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Locoregional disease control after external beam radiotherapy in 91 patients with differentiated thyroid carcinoma and pT4 tumor stage - a single institution experience Cover

Locoregional disease control after external beam radiotherapy in 91 patients with differentiated thyroid carcinoma and pT4 tumor stage - a single institution experience

Open Access
|Sep 2018

Figures & Tables

Figure 1

Disease-specific survival according to T4a and T4b tumor stage (p = 0.07) (bold line, T4b; dotted line, T4a).

Figure 2

Overall survival according to T4a and T4b tumor stage (p = 0.08) (bold line, T4b; dotted line, T4a).

Figure 3

Disease-free survival according to T4a and T4b tumor stage in 64 patients without persistent disease (p = 0.122) (bold line, T4b; dotted line, T4a).

Figure 4

Patients without distant metastases had longer disease-specific survival than those without distant metastases (p < 0.001) (bold line, with metastases; dotted line, without metastases).

Treatment of patients

CharacteristicSubgroupNumber of Patients
Surgery of the thyroidLobectomy or less15
Total or near-total thyroidectomy64
Without surgery12
Neck dissectionNo64
Yes27
Radioiodine ablationNo9
Yes82
Therapy with radioiodineNo54
Yes37
Radiotherapy-Neck regionNo0
Yes91
ChemotherapyNo52
Yes39
Tyrosine kinase inhibitorsNo89
Yes2

Clinical data and outcome of 91 patients with pT4 tumor stage

CharacteristicSubgroupNumber of patients
GenderFemale44
Male47
Patient’s age44 or less15
45 or more76
Tumor diameter (cm)1-975
9.1-3016
T stagepT4a63
pT4b28
Lymph nodes metastasesNo53
Yes38
Distant metastasesNo68
Yes23
Residual tumor after surgeryR027
R147
R25
No surgery12
RecurrenceNo39
Yes-distant13
Yes-locoregional16
Disease present permanently23
OutcomeAlive44
Dead of distant disease29
Dead of local disease1
Dead of local and distant disease4
Dead of other causes10
Lost from follow-up3
DOI: https://doi.org/10.2478/raon-2018-0038 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 453 - 460
Submitted on: May 4, 2018
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Accepted on: May 23, 2018
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Published on: Sep 22, 2018
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2018 Nikola Besic, Marta Dremelj, Gasper Pilko, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.