Table 1
Patient characteristics
| Patient N° | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|---|---|---|---|---|---|---|---|
| Sex | M | M | F | M | M | M | M |
| Age (years) | 41 | 58 | 64 | 74 | 71 | 45 | 55 |
| No of cycles at first eye exam | 2 | 11 | 15 | 3 | 3 | 3 | 6 |
| No of cycles at last eye exam | 3 | 13 | 24 | 8 | 5 | 4 | 7 |
| Change in dosage | yes* | no | no | no | no | no | no |
| BCVA RE | 1.0 | 1.0 | 1.0 | 0.7 – 0.9 | 0.8 | 1.0 | 1.0 |
| BCVA LE | 1.0 | 1.0 | 1.0 | 0.7 – 0.9 | 0.7 | 1.0 | 1.0 |
| Symptoms | circle centrally | blurred vision | no | blurred vision | floaters in LE, blurred vision | circle centrally | no |
| Occurrence of symptoms after starting the therapy | 1 week | 1 week | - | 1 week | 1 month | 1 week | - |
| Fluctuations of symptoms | spontan. resolution | no | - | different spectacles needed | better after topical therapy | spontan. resolution | needs spectacles |
| OCT changes in the fovea | elongatio of IZ | SRF | SRF | SRF | elongation of IZ in RE, SRF in LE | SRF | SRF |
| Extrafoveal SRF | multiple bilateral | multiple bilateral | multiple bilateral | multiple bilateral | no | no | multiple bilateral |
| Other ocular findings | - | - | - | incipient senile cataract ou | uveitis in LE; incipient cataract ou | - | dilatated conjuctival vessels in the RE |
BCVA = best corrected visual acuity; F = female; IZ = interdigitation zone; LE = left eye; M = male, OCT = optical coherence tomography; ou = both eyes; RE = right eye; SRF = subretinal fluid.
Figure 1
(A) Discrete bilateral lesions in the fovea seen on fundus photography(blue arrows); (B) Infrared reflectance imaging showing lesions with a hyperreflective center, surrounded by a hyporeflective zone scattered throughout the posterior pole (some are marked with red arrows); (C) Some lesions showed increased signal in autofluorescence imaging (some are marked with yellow arrows).
Figure 2
(A-C) IR imaging of foveal lesion during cycles; (D-F) OCT showed fluctuations of dome-shaped accumulation of subretinal fluid with elongation of interdigitation zone (green arrows) in the foveal region; A+D = imaging during 3rd cycle; B+E = imaging during 6th cycle; C+F = imaging during 8th cycle.
Figure 3
Fluorescein (A, B) and indocyanine green (C, D) angiography showed only mild masking effect of subretinal fluid on the location of lesions (red arrows).
Figure 4
Discrete morphological changes with focal elongations of interdgitation zone in the fovea (red arrows) and near the vascular arcades (green arrows) seen on OCT.