Have a personal or library account? Click to login
Polymorphisms in folate pathway and pemetrexed treatment outcome in patients with malignant pleural mesothelioma Cover

Polymorphisms in folate pathway and pemetrexed treatment outcome in patients with malignant pleural mesothelioma

Open Access
|Apr 2014

References

  1. 1. Podobnik J, Kocijancic I, Kovac V, Sersa I. 3T MRI in evaluation of asbestosrelated thoracic diseases - preliminary results. Radiol Oncol 2010 ; 44: 92-6.10.2478/v10019-010-0027-7342368522933897
  2. 2. Mineo TC, Ambrogi V. Malignant pleural mesothelioma: factors influencing the prognosis. Oncology (Williston Park) 2012; 26: 1164-75.
  3. 3. Kovac V, Zwitter M, Zagar T. Improved survival after introduction of chemotherapy for malignant pleural mesothelioma in Slovenia: Population-based survey of 444 patients. Radiol Oncol 2012; 46: 136-44.10.2478/v10019-012-0032-0347293823077450
  4. 4. Lee CW, Murray N, Anderson H, Rao SC, Bishop W. Outcomes with firstline platinum-based combination chemotherapy for malignant pleural mesothelioma: a review of practice in British Columbia. Lung Cancer 2009; 64: 308-13.10.1016/j.lungcan.2008.09.00819004520
  5. 5. Raeisi E, Aghamiri SMR, Bandi A, Rahmatpour N, Firoozabadi SM, Kafi-Abad SA, Mir LM. The antitumor efficiency of combined electrochemotherapy and single dose irradiation on a breast cancer tumor model. Radiol Oncol 2012; 46: 226-32.10.2478/v10019-012-0035-x347294723077461
  6. 6. Jeromen A, Oblak I, Anderluh F, Velenik V, Vidmar MS, Ratoša I. Results of postoperative radiochemotherapy of the patients with resectable gastroesophageal junction adenocarcinoma in Slovenia. Radiol Oncol 2012; 46: 337-45.10.2478/v10019-012-0049-4357289023412351
  7. 7. Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 2003; 21: 2636-44.10.1200/JCO.2003.11.13612860938
  8. 8. Berk S, Dogan OT, Kilickap S, Epozturk K, Akkurt I, Seyfikli Z. Clinical characteristics, treatment and survival outcomes in malignant mesothelioma: eighteen years’ experience in Turkey. Asian Pac J Cancer Prev 2012; 13: 5735-9.10.7314/APJCP.2012.13.11.5735
  9. 9. Helland A, Solberg S, Brustugun OT. Incidence and survival of malignant pleural mesothelioma in norway: a population-based study of 1686 cases. J Thorac Oncol 2012; 7: 1858-61.10.1097/JTO.0b013e318275b34623154557
  10. 10. Kovac V, Zwitter M, Rajer M, Marin A, Debeljak A, Smrdel U, et al. A phase II trial of low-dose gemcitabine in a prolonged infusion and cisplatin for malignant pleural mesothelioma. Anticancer Drugs 2012; 23: 230-8.10.1097/CAD.0b013e32834d7a1c22027538
  11. 11. Kao SC, Phan VH, Clarke SJ. Predictive markers for haematological toxicity of pemetrexed. Curr Drug Targets 2010; 11: 48-57.10.2174/13894501079003107219839928
  12. 12. Berger SH, Pittman DL, Wyatt MD. Uracil in DNA: consequences for carcinogenesis and chemotherapy. Biochem Pharmacol 2008; 76: 697-706.10.1016/j.bcp.2008.05.019256202718599024
  13. 13. Franke RM, Sparreboom A. Drug transporters: recent advances and therapeutic applications. Clin Pharmacol Ther 2010; 87: 3-7.10.1038/clpt.2009.23920019691
  14. 14. Chattopadhyay S, Moran RG, Goldman ID. Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications. Mol Cancer Ther 2007; 6: 404-17.10.1158/1535-7163.MCT-06-034317308042
  15. 15. Silverton L, Dean M, Moitra K. Variation and evolution of the ABC transporter genes ABCB1, ABCC1, ABCG2, ABCG5 and ABCG8: implication for pharmacogenetics and disease. Drug Metabol Drug Interact 2011; 26: 169-79.10.1515/DMDI.2011.027737270922098604
  16. 16. Adjei AA, Salavaggione OE, Mandrekar SJ, Dy GK, Ziegler KL, Endo C, et al. Correlation between polymorphisms of the reduced folate carrier gene (SLC19A1) and survival after pemetrexed-based therapy in non-small cell lung cancer: a North Central Cancer Treatment Group-based exploratory study. J Thorac Oncol 2010; 5: 1346-53.10.1097/JTO.0b013e3181ec18c4573541920651609
  17. 17. Tiseo M, Giovannetti E, Tibaldi C, Camerini A, Di Costanzo F, Barbieri F, et al. Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexedcarboplatin. Lung Cancer 2012; 78: 92-9.10.1016/j.lungcan.2012.07.00922889494
  18. 18. Zucali PA, Giovannetti E, Destro A, Mencoboni M, Ceresoli GL, Gianoncelli L, et al. Thymidylate synthase and excision repair cross-complementing group-1 as predictors of responsiveness in mesothelioma patients treated with pemetrexed/carboplatin. Clin Cancer Res 2011; 17: 2581-90.10.1158/1078-0432.CCR-10-287321262916
  19. 19. Kovac V, Zwitter M. Cisplatin with Alimta or gemcitabine in long infusion for mesothelioma (AGILI). Available at: http://clinicaltrials.gov/ct2/showNCT01281800. Accessed Januar y 16, 2013.
  20. 20. Byrne MJ, Nowak AK. Modified RECIST criteria for assessment of response in malignant pleural mesothelioma. Ann Oncol 2004; 15: 257-60.10.1093/annonc/mdh05914760119
  21. 21. National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0. Available at: http://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm. Accessed February 15, 2012
  22. 22. Erculj N, Kotnik BF, Debeljak M, Jazbec J, Dolzan V. The influence of folate pathway polymorphisms on high-dose methotrexate related toxicity and survival in children with non-Hodgkin malignant lymphoma. Radiol Oncol 2013; doi:10.2478/raon-2013-0076. 2013.10.26. [Epub ahea d of print]
  23. 23. Erculj N, Kotnik BF, Debeljak M, Jazbec J, Dolzan V. Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia. Leuk Lymphoma 2012; 53: 1096-104.10.3109/10428194.2011.63988022074251
  24. 24. Kastelic M, Koprivsek J, Plesnicar BK, Serretti A, Mandelli L, Locatelli I, et al. MDR1 gene polymorphisms and response to acute risperidone treatment. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34: 387-92.10.1016/j.pnpbp.2010.01.00520060871
  25. 25. Tregouet DA, Garelle V. A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies. Bioinformatics 2007; 23: 1038-9.10.1093/bioinformatics/btm05817308338
  26. 26. Erculj N, Kovac V, Hmeljak J, Franko A, Dodic-Fikfak M, Dolzan V. The influence of gemcitabine pathway polymorphisms on treatment outcome in patients with malignant mesothelioma. Pharmacogenet Genomics 2012; 22: 58-68.10.1097/FPC.0b013e32834e357222134350
  27. 27. Righi L, Papotti MG, Ceppi P, Bille A, Bacillo E, Molinaro L, et al. Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy. J Clin Oncol 2010; 28: 1534-9.10.1200/JCO.2009.25.927520177021
  28. 28. Christoph DC, Asuncion BR, Mascaux C, Tran C, Lu X, Wynes MW, et al. Folylpoly-glutamate synthetase expression is associated with tumor response and outcome from pemetrexed-based chemotherapy in malignant pleural mesothelioma. J Thorac Oncol 2012; 7: 1440-8.10.1097/JTO.0b013e318260deaa364594022895141
  29. 29. Christoph DC, Asuncion BR, Hassan B, Tran C, Maltzman JD, O’Shannessy DJ, et al. Significance of folate receptor alpha and thymidylate synthase protein expression in patients with non-small-cell lung cancer treated with pemetrexed. J Thorac Oncol 2013; 8: 19-30.10.1097/JTO.0b013e31827628ff364593623242435
  30. 30. Sun JM, Han J, Ahn JS, Park K, Ahn MJ. Significance of thymidylate synthase and thyroid transcription factor 1 expression in patients with nonsquamous non-small cell lung cancer treated with pemetrexed-based chemotherapy. J Thorac Oncol 2011; 6: 1392-9.10.1097/JTO.0b013e3182208ea821716147
  31. 31. Smit EF, Burgers SA, Biesma B, Smit HJ, Eppinga P, Dingemans AM, et al. Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer. J Clin Oncol 2009; 27: 2038-45.10.1200/JCO.2008.19.165019307503
  32. 32. Hu Q, Li X, Su C, Chen X, Gao G, Zhang J, et al. Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer. Exp Ther Med 2012; 4: 1010-6.10.3892/etm.2012.730349412523226765
  33. 33. Christensen KE, Rohlicek CV, Andelfinger GU, Michaud J, Bigras JL, Richter A, et al. The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects. Hum Mutat 2009; 30: 212-20.10.1002/humu.2083018767138
  34. 34. Krajinovic M, Lemieux-Blanchard E, Chiasson S, Primeau M, Costea I, Moghrabi A. Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia. Pharmacogenomics J 2004; 4: 66-72.10.1038/sj.tpj.650022414647408
  35. 35. Ranganathan P, Culverhouse R, Marsh S, Mody A, Scott-Horton TJ, Brasington R, et al. Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. J Rheumatol 2008; 35: 572-9.
  36. 36. Sai K, Saito Y, Itoda M, Fukushima-Uesaka H, Nishimaki-Mogami T, Ozawa S, et al. Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population. Drug Metab Pharmacokinet 2008; 23: 139-47.10.2133/dmpk.23.13918445995
  37. 37. Sun N, Sun X, Chen B, Cheng H, Feng J, Cheng L, et al. MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer. Cancer Chemother Pharmacol 2010; 65: 437-46.10.1007/s00280-009-1046-1279742119568750
  38. 38. Campa D, Muller P, Edler L, Knoefel L, Barale R, Heussel CP, et al. A comprehensive study of polymorphisms in ABCB1, ABCC2 and ABCG2 and lung cancer chemotherapy response and prognosis. Int J Cancer 2012; 131: 2920-8.10.1002/ijc.2756722473764
  39. 39. Niemi M, Pasanen MK, Neuvonen PJ. Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev 2011; 63: 157-81.10.1124/pr.110.00285721245207
  40. 40. Trevino LR, Shimasaki N, Yang W, Panetta JC, Cheng C, Pei D, et al. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol 2009; 27: 5972-8.10.1200/JCO.2008.20.4156279304019901119
  41. 41. Ramsey LB, Bruun GH, Yang W, Trevino LR, Vattathil S, Scheet P, et al. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res 2012; 22: 1-8.10.1101/gr.129668.111324619622147369
  42. 42. Vidan-Jeras B, Jurca B, Dolzan V, Jeras M, Breskvar K, Bohinjec M. Slovenian Caucasian normal. In: Gjertson D, Terasaki P, editors. HLA 1998. Kansas: American society for histocompatibility and immunogenetics, Lenexa; 1998 . p. 180-1.
  43. 43. Erculj N, Kovac V, Hmeljak J, Dolzan V. The influence of platinum pathway polymorphisms on the outcome in patients with malignant mesothelioma. Ann Oncol 2012; 23: 961-7.10.1093/annonc/mdr32421765044
  44. 44. Erculj N, Kovac V, Hmeljak J, Franko A, Dodic-Fikfak M, Dolzan V. DNA repair polymorphisms and treatment outcomes of patients with malignant mesothelioma treated with gemcitabine-platinum combination chemotherapy. J Thorac Oncol 2012; 7: 1609-17 10.1097/JTO.0b013e3182653d3122982660
DOI: https://doi.org/10.2478/raon-2013-0086 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 163 - 172
Submitted on: Oct 12, 2013
|
Accepted on: Oct 23, 2013
|
Published on: Apr 25, 2014
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2014 Katja Goricar, Viljem Kovac, Vita Dolzan, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.