Have a personal or library account? Click to login
Clonality analysis of lymphoid proliferations using the BIOMED-2 clonality assays: a single institution experience Cover

Clonality analysis of lymphoid proliferations using the BIOMED-2 clonality assays: a single institution experience

Open Access
|Apr 2014

References

  1. 1. Sandberg Y, van Gastel-Mol EJ, Verhaaf B, Lam KH, van Dongen JJ, Langerak AW. BIOMED-2 multiplex immunoglobulin/T-cell receptor polymerase chain reaction protocols can reliably replace Southern blot analysis in routine clonality diagnostics. J Mol Diagn 2005; 7: 495-503.10.1016/S1525-1578(10)60580-6
  2. 2. Hoeve MA, Krol AD, Philippo K, Derksen PW, Veenendaal RA, Schuuring E, et al. Limitations of clonality analysis of B cell proliferations using CDR3 polymerase chain reaction. J Clin Pathol Mol Pathol 2000; 53: 194-200.10.1136/mp.53.4.194
  3. 3. van Krieken JH, Langerak AW, Macintyre EA, Kneba M, Hodges E, Garcia Sanz R, et al. Improved reliability of lymphoma diagnostics via PCR-based clonality testing: - Report of the BIOMED-2 concerted action BHM4-CT98-3936. Leukemia 2007; 21: 201-6.10.1038/sj.leu.2404467
  4. 4. McCarthy KP, Sloane JP, Wiedemann LM. Rapid method for distinguishing clonal from polyclonal B cell populations in surgical biopsy specimens. J Clin Pathol 1990; 43: 429-32.10.1136/jcp.43.5.429
  5. 5. Trainor KJ, Brisco MJ, Wan JH, Neoh S, Grist S, Morley AA. Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain reaction. Blood 1991; 78: 192-5.10.1182/blood.V78.1.192.192
  6. 6. Slack DN, McCarthy KP, Wiedemann LM, Sloane JP. Evaluation of sensitivity, specificity and reproducibility of an optimized method for detecting clonal rearrangements of immunoglobulin and T-cell receptor genes in formalinfixed, paraffin-embedded sections. Diagn Mol Pathol 1993; 2: 223-32.10.1097/00019606-199312000-00001
  7. 7. Segal GH, Jorgensen T, Masih AS, Braylan TC. Optimal primer selection for clonality assessment by polymerase chain reaction analysis: I. Low grade B-cell lymphoproliferative disorders of nonfollicular center cell type. Hum Pathol 1994; 25: 1269-75.10.1016/0046-8177(94)90084-1
  8. 8. Davis TH, Courtland EY, Balk SP. Detection of clonal immunoglobulin gene rearrangements by polymerase chain reaction amplification and single-strand conformational polymorphism analysis. Am J Pathol 1993; 142: 1841-47.
  9. 9. Chen YT, Whitney KD, Chen Y. Clonality analysis of B-cell lymphoma in freshfrozen and paraffin-embedded tissues: The effects of variable polymerase chain reaction parameters. Mod Pathol 1994; 7: 429-34.
  10. 10. McCarthy KP, Sloane JP, Wiedemann LM. A simplified method of detection of clonal rearrangements of the T-cell receptor g chain gene. Diagn Mol Pathol 1992; 1: 173-79.
  11. 11. Theodorou I, Raphael M, Bigorgne C, Fourcade C, Lahet C, Cochet G, et al. Recombination pattern of the TCRg locus in human peripheral T-cell lymphomas. J Pathol 1994; 174: 233-42.10.1002/path.17117404027884584
  12. 12. Diss TC, Watts M, Pan LX, Burke M, Linch D, Isaacson PG. The polymerase chain reaction in the demonstration of monoclonality in T cell lymphomas. J Clin Pathol 1995; 48: 1045-50.10.1136/jcp.48.11.10455030128543629
  13. 13. Liu H, Bench AJ, Bacon CM, Payne K, Huang Y, Scott MA, et al. A practical strategy for the routine use of BIOMED-2 PCR assays for detection of B- and T-cell clonality in diagnostic haematopathology. Br J Haematol 2007; 138: 31-43.10.1111/j.1365-2141.2007.06618.x17555445
  14. 14. van Dongen JJ, Langerak AW, Brüggemann M, Evans PA, Hummel M, Lavender FL, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptore gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Leukemia 2003; 17: 2257-317.10.1038/sj.leu.2403202
  15. 15. Evans PA, Pott C, Groenen PJ, Salles G, Davi F, Berger F, et al. Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Leukemia 2007; 21: 207-14.10.1038/sj.leu.2404479
  16. 16. Brüggemann M, White H, Gaulard P, Garcia-Sanz R, Gameiro P, Oeschger S, et al. Powerful strategy for polymerase chain reaction-based clonality assessment in T-cell malignancies. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Leukemia 2007; 21: 215-21.10.1038/sj.leu.2404481
  17. 17. Langerak AW, Molina TJ, Lavender FL, Pearson D, Flohr T, Sambade C, et al. Polymerase chain reaction-based clonality testing in tissue samples with reactive lymphoproliferations: usefulness and pitfalls. A report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Leukemia 2007; 21: 222-29.10.1038/sj.leu.2404482
  18. 18. Langerak AW, Groenen PJ, van Krieken JH, van Dongen JJ. Immunoglobulin/Tcell receptor clonality diagnostics. Expert Opin Med Diagn 2007; 1: 451-61.10.1517/17530059.1.4.451
  19. 19. Groenen PJ, Langerak AW, van Dongen JJ, van Krieken JH. Pitfalls in TCR gene clonality testing: teaching cases. J Hematopathol 2008; 1: 97-109.10.1007/s12308-008-0013-9
  20. 20. Matthews C, Catherwood M, Morris TC, Alexander HD. Routine analysis of IgHV mutational status in CLL patients using BIOMED-2 standardized primers and protocols. Leuk Lymphoma 2004; 45: 1899-904.10.1080/10428190410001710812
  21. 21. Dawidovska M, Jólkowska J, Sczepański T, Derwich K, Wachowiak J, Witt M. Implementation of the standard strategy for identification of Ig/TCR targets for minimal residual disease diagnostics in B-cell precursor ALL pediatric patients: Polish experience. Arch Immunol Ther Exp 2008; 56: 409-18.10.1007/s00005-008-0045-y
  22. 22. Chen YL, Su IJ, Cheng HY, Chang KC, Lu CC, Chow NH, et al. BIOMED-2 protocols to detect clonal immunoglobulin and T-cell receptor gene rearrangements in B- and T-cell lymphomas in southern Taiwan. Leuk Lymphoma 2010; 51: 650-55.10.3109/10428191003660631
  23. 23. Lassmann S, Gerlach UV, Technau-Ihling K, Werner M, Fisch P. Application of BIOMED-2 primers in fixed and decalcified bone marrow biopsies: analysis of immunoglobulin H receptor rearrangements in B-cell non-Hodgkin’s lymphomas. J Mol Diagn 2005; 7: 582-91.10.1016/S1525-1578(10)60591-0
  24. 24. Lukowsky A, Marchwat M, Sterry W, Gellrich S. Evaluation of B-cell clonality in archival skin biopsy samples of cutaneous B-cell lymphoma by immunoglobulin heavy chain gene polymerase chain reaction. Leuk Lymphoma 2006; 47: 487-93.10.1080/1042819050030538016396773
  25. 25. Hebeda KM, van Altena MC, Rombout P, van Krieken JH, Groenen PJ. PCR clonality detection in Hodgkin lymphoma. J Hematopathol 2009;2:34-41. 10.1007/s12308-009-0024-1271349219669221
  26. 26. Burack WR, Laughlin TS, Friedberg JW, Spence JM, Rothberg PG. PCR assays detect B-lymphocyte clonality in formalin-fixed, paraffin-embedded specimens of classical Hodgkin lymphoma without microdissection. Am J Clin Pathol 2010; 134: 104-11.10.1309/AJCPK6SBE0XOODHB304678020551274
  27. 27. Zhang S, Abreo F, Lowery-Nordberg M, Veillon DM, Cotelingam JD. The role of fluorescence in situ hybridization and polymerase chain reaction in the diagnosis and classification of lymphoproliferative disorders on fine-needle aspiration. Cancer Cytopathol 2010; 118: 105-12.10.1002/cncy.2007020340097
  28. 28. Payne K, Wright P, Grant JW, Huang Y, Hamoudi J, Bacon CM, et al. BIOMED-2 PCR assays for IGK gene rearrangements are essential for B-cell clonality analysis in follicular lymphoma. Br J Haematol 2011; 155: 84-92.10.1111/j.1365-2141.2011.08803.x21790530
  29. 29. Berget E, Helgeland L, Molven A, Vintermyr OK. Detection of clonality in follicular lymphoma using formalin-fixed, paraffin-embedded tissue samples and BIOMED-2 immunoglobulin primers. J Clin Pathol 2011; 64: 37-41.10.1136/jcp.2010.08110921030528
  30. 30. Sandberg Y, Heule F, Lam K, Lugtenburg PJ, Wolvers-Tettero IL, van Dongen JJ, et al. Molecular immunoglobulin/T-cell receptor clonality in cutaneous lymphoproliferations. Experience with the BIOMED-2 standardized polymerase chain reaction protocol. Haematologica 2003; 88: 659-70.
  31. 31. Catherwood MA, Gonzales D, Patton C; Dobbin E, Venkatraman L, Alexander HD. Improved clonality assessment in germinal centre/post germinal centre non- Hodgkin’s lymphomas with high rates of somatic hypermutation. J Clin Pathol 2007; 60: 524-28.
  32. 32. Tan BT, Seo K, Warnke RA, Arber DA. The frequency of immunoglobulin heavy chain gene and T-cell receptor g-chain gene rearrangements and Epstein-Barr virus in ALK+ and ALK- anaplastic large cell lymphoma and other peripheral T-cell lymphomas. J Mol Diagn 2008; 10: 502-12.10.2353/jmoldx.2008.080054257063318832464
  33. 33. Zhang B, Beck AH, Taube JM, Kohler S, Seo K, Zwerner J, et al. Combined use of PCR-based TCRG and TCRB clonality tests on paraffin-embedded skin tissue in the differential diagnosis of Mycosis fungoides and inflammatory dermatoses. J Mol Diagn 2010; 12: 320-27.10.2353/jmoldx.2010.090123286046820203005
  34. 34. Nakamichi N, Wada N, Kohara M, Fukuhara S, Sugiyama H, Ogawa H, et al. Polymorphous lymphoproliferative disorder: a clinicopathological analysis.Virchows Arch 2010; 456: 269-76.10.1007/s00428-010-0880-120111873
  35. 35. Dabiri S, Morales A, Ma L, Sundram U, Kim YH, Arber DA, et al. The frequency of dual TCR-PCR clonality in granulomatous disorders. J Cutan Pathol 2011; 38: 704-9.10.1111/j.1600-0560.2011.01727.x21645036
  36. 36. McClure RF, Kaur P, Pagel E, Ouillette PD, Holtegaard CE, Treptow CL, et al. Validation of immunoglobulin gene rearrangement detection by PCR using commercially available BIOMED-2 primers. Leukemia 2006; 20: 176-79.10.1038/sj.leu.240404916307010
  37. 37. Patel KP, Pan Q, Wang Y, Maitta RW; Du J, Xue X, et al. Comparison of BIOMED-2 versus laboratory-developed polymerase chain reaction assays for detecting T-cell receptor-g gene rearrangements. J Mol Diagn 2010; 12: 226-37.10.2353/jmoldx.2010.090042287173020181819
  38. 38. Zaki MA, Wada N, Kohara M, Ikeda J, Hori Y, Fujita S, et al. Presence of B-cell clones in T-cell lymphoma. Eur J Haematol 2011; 86: 412-19.10.1111/j.1600-0609.2011.01597.x21362051
  39. 39. Langerak AW, Groenen PJ, Brüggemann M, Beldjord K, Bellan C, Bonello L, et al. EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations. Leukemia 2012; 26: 2159-71. 10.1038/leu.2012.246346978922918122
  40. 40. Jaffe ES, Harris NL, Stein H and Vardiman JW: Tumours of Haematopoietic and Lymphoid Tissues. In: World Health Organization Classification of Tumours. Lyon: IARC Press; 2001.
  41. 41. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2008.
  42. 42. Diss TC, Peng H, Wotherspoon AC, Isaacson PG, Pan L. Detection of monoclonality in low-grade B-cell lymphomas using the polymerase chain reaction is dependent on primer selection and lymphoma type. J Pathol 1993; 169: 291-95.10.1002/path.17116903038492220
  43. 43. Posnett DN, Sinha R, Kabak S, Russo C. Clonal populations of T cells in normal elderly humans: the T cell equivalent to “benign monoclonal gammapathy”. J Exp Med 1994; 179: 609-18.10.1084/jem.179.2.60921913748294871
  44. 44. Delfau-Larue MH, Laroche L, Wechsler J, Lepage E, Lahet C, Asso-Bonnet M, et al. Diagnostic value of dominant T-cell clones in peripheral blood in 363 patients presenting consecutively with a clinical suspicion of cutaneous lymphoma. Blood 2000; 96: 2987-92.10.1182/blood.V96.9.2987
  45. 45. Godges E, Krishna MT, Pickard C, Smith JL. Diagnostic role of test for T cell receptor (TCR) genes. J Clin Pathol 2003; 56: 1-11. 10.1136/jcp.56.1.1176986512499424
DOI: https://doi.org/10.2478/raon-2013-0072 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 155 - 162
Submitted on: May 9, 2013
|
Accepted on: Oct 1, 2013
|
Published on: Apr 25, 2014
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2014 Ira Kokovic, Barbara Jezersek Novakovic, Petra Cerkovnik, Srdjan Novakovic, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.