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References

  1. Alves, N., Zaror, C., del Sol, M., Bagnato, V. S., Deana, N. F. (2022). Effects of laser photobiomodulation on TGF-ß and VEGF expression in burn wound: Systematic review and meta-analysis in the animal model. Int. J. Morphol., 40 (1), 194–203. http://dx.doi.org/10.4067/S0717-95022022000100194
  2. Arany, P. R. (2022). Photobiomodulation-activated latent transforming growth factor-β1: A critical clinical therapeutic pathway and an endogenous optogenetic tool for discovery. Photobiomodul. Photomed. Laser Surg., 40 (2), 136–147. https://doi.org/10.1089/photob.2021.0109
  3. Babtan, A. M., Ilea, A., Feurdean, C. N., Ceci, S., Pula, B., Candrea, S., Azzollini, D., Piras, F., Curatoli, L., Corriero, A., … Cardarelli, F. (2022). Biostimulation with low-level laser therapy and its effects on soft and hard tissue regeneration. Literature Review. J. Mind Med. Sci., 9 (1), 28–37. https://doi.org/10.22543/7674.91.P2837
  4. Biasucci, L. M., Maino, A., Grimaldi, M. C., Cappannoli, L., Aspromonte, N. (2021). Novel biomarkers in heart failure: New insight in pathophysiology and clinical perspective. J. Clin. Med., 10 (13), 2771. https://doi.org/10.3390/jcm10132771
  5. Chamkouri, H., Liu, Q., Zhang, Y., Chen, C., Chen, L. (2024). Brain photobiomodulation therapy on neurological and psychological diseases. J. Biophotonics. 17 (1), e202300145. https://doi.org/10.1002/jbio.202300145
  6. Cowan, D. A., Moncrieffe, D. A. (2022). Procollagen type III amino-terminal propeptide and insulin-like growth factor I as bio-markers of growth hormone administration. Drug Test. Anal., 14 (5), 808–819. https://doi.org/10.1002/dta.3155
  7. Directive 2010/63/EU (2010). Directive 2010/63/EU of the European Parliament and of the Council, of 22 September 2010, on the Protection of Animals Used for Scientific Purposes. https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2010:276:0033:0079:en:PDF
  8. El Ayadi, A., Jay, J. W., Prasai, A. (2020). Current approaches targeting the wound healing phases to attenuate fibrosis and scarring. Int. J. Mol. Sci., 21 (3), 1105. https://doi.org/10.3390/ijms21031105
  9. European Convention (1986). European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes. https://rm.coe.int/168007a67b
  10. Fiorio, F. B., Dos Santos, S. A., de Melo Rambo, C. S., Dalbosco, C. G., Serra, A. J., de Melo, B. L., Leal-Junior, E. C. P., de Carvalho, P. T. C. (2017). Photobiomodulation therapy action in wound repair skin induced in aged rats old: Time course of biomarkers inflammatory and repair. Lasers Med. Sci., 32 (8), 1769–1782. https://doi.org/10.1007/s10103-017-2254-2
  11. Gal, P., Kilik, R., Mokry, M., Vidinsky, B., Vasilenko, T., Mozes, S., Bobrov, N., Tomori, Z., Bober, J., Lenhardt, L. (2008). Simple method of open skin wound healing model in corticosteroid-treated and diabetic rats: Standardization of semi-quantitative and quantitative histological assessments. Vet. Med-Czech., 53 (12), 652–659. https://10.17221/1973-VETMED
  12. Gao, M., Guo, H., Dong, X., Wang, Z., Yang, Z., Shang, Q., Wang, Q. (2024). Regulation of inflammation during wound healing: The function of mesenchymal stem cells and strategies for therapeutic enhancement. Front. Pharmacol., 15, 1345779. https://doi.org/10.3389/fphar.2024.1345779
  13. Guide for the Care and Use of Laboratory Animals (2011). National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals. 8th edition. National Academies Press (US), Washington (DC). https://www.ncbi.nlm.nih.gov/books/NBK54040/
  14. Keskiner, I., Lutfioğlu, M., Aydogdu, A., Saygun, N. I., Serdar, M. A. (2016). Effect of photobiomodulation on transforming growth factor-β1, platelet-derived growth factor-BB, and interleukin-8 release in palatal wounds after free gingival graft harvesting: A randomized clinical study. Photomed. Laser. Surg., 34 (6), 263–271. https://doi.org/10.1089/pho.2016.4094
  15. Khan, I., Rahman, S. U., Tang, E., Engel, K., Hall, B., Kulkarni, A. B., Arany, P. R. (2021). Accelerated burn wound healing with photobiomodulation therapy involves activation of endogenous latent TGF-β1. Sci. Rep., 11, 13371. https://doi.org/10.1038/s41598-021-92650-w
  16. Kolimi, P., Narala, S., Nyavanandi, D., Youssef, A. A. A., Dudhipala, N. (2022). Innovative treatment strategies to accelerate wound healing: Trajectory and recent advancements. Cells, 11 (15), 2439. https://doi.org/10.3390/cells11152439
  17. Kumechko, М., Babenko, N., Pavlov, S., Litvinova, О., Torianyk, І., Babaieva, О. (2025). Correction of regulatory molecules expression at the inflammation stage using photobiomodulation therapy in chronic wound modeling. The Journal of V.N. Karazin Kharkiv National University. Series Medicine, 33 (3 (54)), 365–376. https://doi.org/10.26565/2313-6693-2025-54-05
  18. Lawrence, J., Sorra, K. (2024). Photobiomodulation as medicine: Low-level laser therapy (LLLT) for acute tissue injury or sport performance recovery. J. Funct. Morphol. Kinesiol., 9 (4), 181. https://doi.org/10.3390/jfmk9040181
  19. Litvinova, O., Babenko, N., Pavlov, S., Kumetchko, M., Torianyk, I. (2025). Histological assessment of the effectiveness of photobiomodulation therapy in healing experimental complicated wounds. Lett. Appl. NanoBioScience, 14, 236. https://doi.org/10.33263/LIANBS144.23620
  20. Lurin, I., Khoroshun, E., Seliukova, N., Rekhviashvili, M., Makarov, V., Boiko, M., Nehoduiko, V., Misiura, K. (2024). The hormonal status of male combatants depending on the volume of body wounding. Int. J. Endocrinol. (Ukraine), 20 (5), 349–356. https://doi.org/10.22141/2224-0721.20.5.2024.1419
  21. Matsui, C., Koide, H., Ikeda, T., Ikegami, T., Yamamoto, T., Escandón, J. M., Mohammad, A., Ito, T., Mizuno, H. (2024). Cytokines released from human adipose tissue-derived stem cells by bFGF stimulation: Effects of IL-8 and CXCL-1 on wound healing. Regen. Ther., 26, 401–406. https://doi.org/10.1016/j.reth.2024.06.008
  22. Pavlov, S. B., Babalyan, V. O., Valilshchikov, M. V., Babenko, N. M., Kumetchko, M. V., Litvinova, O. B., Semko, N. G. (2022). The role of cytokines in the mechanisms of regulation of reparative processes in modeling fractures of the proximal femur secondary to the correction of concomitant arterial hypertension. Minerva Orthop., 73 (3), 287–293. https://doi.org/10.23736/S2784-8469.21.04126-6
  23. Pavlov, S. B., Babenko, N. M., Kumetchko, M. V., Litvinova, O. B., Semko, N. G., Mikhaylusov, R. N. (2020). The influence of photobiomodulation therapy on chronic wound healing. Rom. Rep. Phys., 72, 609.
  24. Pavlov, S., Babenko, N., Kumetchko, M., Litvinova, O. (2024). Features of the regulation of reparative processes of chronic wounds in response to the effect of photobiomodulation therapy on a wound defect. Photobiomodulation therapy for chronic wounds. Folia Med. Cracov., 64 (1), 75–85. https://doi.org/10.24425/fmc.2024.150144
  25. Pavlov, S., Babenko, N., Kumetchko, M., Litvinova, O., Mikhaylusov, R. (2024). Features of metabolism in chronic wound remodelling. Scr. Med., 55 (1), 53–61. https://doi.org/10.5937/scrip-tamed55-48179
  26. Sena, N. F. G. de., Meira, C. E. (2024). Photobiomodulation in the stability of dental implants. Res. Soc. Dev., 13 (7), e13913746238. https://doi.org/10.33448/rsd-v13i7.46238
  27. Shi, G., Wei, K., Wang, R., Wang, Y., Wang, X., Gao, L., Li, S., Yang, B., Tuerxunaili, L., Jiao, Y. (2026). Mechanisms of action and clinical research progress of photobiomodulation. J. Photo-chem. Photobiol. B, 282, 113529, https://doi.org/10.1016/j.jphotobiol.2026.113529
  28. Smith, J., Rai, V. (2024). Novel factors regulating proliferation, migration, and differentiation of fibroblasts, keratinocytes, and vascular smooth muscle cells during wound healing. Biomedicines, 12 (9), 1939. https://doi.org/10.3390/biomedicines12091939
  29. Wong, R. S. Y., Tan, T., Pang, A. S. R., Srinivasan, D. K. (2025). The role of cytokines in wound healing: From mechanistic insights to therapeutic applications. Explor. Immunol., 5, 1003183. https://doi.org/10.37349/ei.2025.1003183
DOI: https://doi.org/10.2478/prolas-2026-0029 | Journal eISSN: 2255-890X (formerly 1407-009X) | Journal ISSN: 1407-009X
Language: English
Page range: 283 - 288
Submitted on: Mar 4, 2025
Accepted on: Sep 16, 2026
Published online: Nov 3, 2026
Published in print: Oct 1, 2026
Published by: Latvian Academy of Sciences
In partnership with: Paradigm Publishing Services

© 2026 Sergey Pavlov, Nataliia Makieieva, Nataliia Babenko, Marina Kumetchko, Olga Litvinova, Volodymyr Babalian, published by Latvian Academy of Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.