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Impact of Vitamin D Therapy on C-Reactive Protein, Ferritin, and IL-6 Levels in Hospitalised Covid-19 Patients Cover

Impact of Vitamin D Therapy on C-Reactive Protein, Ferritin, and IL-6 Levels in Hospitalised Covid-19 Patients

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
Volume 77 (2023): Issue 3-4 (August 2023)
By: Sintija Sauša,  Svjatoslavs Kistkins,  Lelde Krūzmane,  Daina Kalniņa,  Betija Jurģe,  Kristīne Ivanova,  Zane Svikle,  Aija Frīdvalde,  Valērija Roškova,  Rebeka Elīza Zariņa,  Terēze Treimane,  Kristīne Geldnere,  Ilva Trapiņa and  Valdis Pīrāgs  
Open Access
|Sep 2023

References

  1. Alcala-Diaz, J. F., Limia-Perez, L., Gomez-Huelgas, R., Martin-Escalante, M. D., Cortes-Rodriguez, B., Zambrana-Garcia, J. L., Entrenas-Castillo, M., Perez-Caballero, A. I., López-Carmona, M. D., Garcia-Alegria, J., et al. (2021). Calcifediol treatment and hospital mortality due to COVID-19: A cohort study. Nutrients, 13 (6), 1760. DOI: 10.3390/nu13061760.
    Search in Google ScholarBack to article
  2. Amer, M., Qayyum, R. (2012). Relation between serum 25-hydroxyvitamin D and C-ractive protein in asymptomatic adults. Amer. J. Cardiol., 109 (2), 226–230. DOI: 10.1016/j.amjcard.2011.08.032.
    Search in Google ScholarBack to article
  3. Annweiler, C., Beaudenon, M., Gautier, J., Gonsard, J., Boucher, S., Chapelet, G., Darsonval, A., Fougčre, B., Guérin, O., Houvet, M., et al. (2022). High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, open-label, randomized controlled superiority trial. PloS, 19 (5), e1003999. DOI: 10.1371/journal.pmed.1003999.
    Search in Google ScholarBack to article
  4. Annweiler, C., Hanotte, B., Grandin de l'Eprevier, C., Sabatier, J. M., Lafaie, L., Célarier, T. (2020). Vitamin D and survival in COVID-19 patients: A quasi-experimental study. J. Steroid Biochem. Mol. Biol., 204, 105771. DOI: 10.1016/j.jsbmb.2020.105771.
    Search in Google ScholarBack to article
  5. Arabi, S. M., Ranjbar, G., Bahrami, L. S., Vafa, M., Norouzy, A. (2020). The effect of vitamin D supplementation on hemoglobin concentration: A systematic review and meta-analysis. Nutrition, 19 (1), 11. DOI: 10.1186/s12937-020-0526-3.
    Search in Google ScholarBack to article
  6. Asghar, M. S., Yasmin, F., Ahsan, M. N., Alvi, H., Taweesedt, P., Surani, S. (2021). Comparison of first and second waves of COVID-19 through severity markers in ICU patients of a developing country. J. Community Hosp. Intern. Med. Perspect., 11 (5), 576–584. DOI: 10.1080/20009666.2021.1949793.
    Search in Google ScholarBack to article
  7. Aspell, N., Laird, E., Healy, M., Shannon, T., Lawlor, B., O’Sullivan, M. (2019). The prevalence and determinants of vitamin D status in community-dwelling older adults: Results from the English longitudinal study of ageing (ELSA). Nutrients, 11 (6), 1253. DOI: 10.3390/nu11061253.
    Search in Google ScholarBack to article
  8. Azizi-Soleiman, F., Vafa, M., Abiri, B., Safavi, M. (2016). Effects of iron on vitamin D metabolism: A systematic review. Int. J. Prev. Med., 7, 126. DOI: 10.4103/2008-7802.195212.
    Search in Google ScholarBack to article
  9. Bassatne, A., Basbous, M., Chakhtoura, M., El Zein, O., Rahme, M., El-Hajj Fuleihan, G. (2021). The link between COVID-19 and vitamin D (VIVID): A systematic review and meta-analysis. Metab. Clin. Exper., 119, 154753. DOI: 10.1016/j.metabol.2021.154753.
    Search in Google ScholarBack to article
  10. Bilezikian, J. P., Binkley, N., De Luca, H. F., Fassio, A., Formenti, A. M., El-Hajj, Fuleihan, G., Heijboer, A. C., Giustina, A. (2023). Consensus and controversial aspects of vitamin D and COVID-19. J. Clin Endocrinol Metab., 108 (5), 1034–1042. DOI: 10.1210/clinem/dgac719.
    Search in Google ScholarBack to article
  11. Butler-Laporte, G., Nakanishi, T., Mooser, V., Morrison, D. R., Abdullah, T., Adeleye, O., Mamlouk, N., Kimchi, N., Afrasiabi, Z., Rezk, N., et al. (2021). Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study. PLoS Med., 18 (6), e1003605. DOI: 10.1371/journal.pmed.1003605.
    Search in Google ScholarBack to article
  12. Calton, E. K., Keane, K. N., Newsholme, P., Soares, M. J. (2015). The impact of vitamin D levels on inflammatory status: A systematic review of immune cell studies. PLoS One, 10 (11), e0141770. DOI: 10.1371/journal.pone.0141770.
    Search in Google ScholarBack to article
  13. Cannata-Andía, J. B., Díaz-Sottolan, A., Fernández, P., Palomo-Antequera, C., Herrero-Puente, P., Mouzo, R., Carrillo-López, N., Panizo, S., Ibańez, G. H., Cusumano, C. A., et al. (2022). A single-oral bolus of 100,000 IU of cholecalciferol at hospital admission did not improve outcomes in the COVID-19 disease: The COVID-VIT-D — a randomised multicentre international clinical trial. BMC Med., 20 (1). DOI: 10.1186/s12916-022-02290-8.
    Search in Google ScholarBack to article
  14. Da Rocha, A. P., Atallah, A. N., Aldrighi, J. M., Pires, A., Dos Santos Puga, M. E., Pinto, A. (2021). Insufficient evidence for vitamin D use in COVID-19: A rapid systematic review. Int. J. Clin. Pract., 75 (11), e14649. DOI: 10.1111/ijcp.14649.
    Search in Google ScholarBack to article
  15. Demir, A. D., Durmaz, Z. H. (2021). A Ccomparison of vitamin D deficiency with neutrophil lymphocyte ratio and CRP levels in COVID-19 patients. Med. Sci. Discovery, 8 (5), 306–309. DOI: 10.36472/msd.v8i5.537.
    Search in Google ScholarBack to article
  16. Demir, M., Demir, F., Aygun, H. (2021). Vitamin D deficiency is associated with COVID-19 positivity and severity of the disease. J. Med. Virol., 93 (5), 2992–2999. DOI: 10.1002/jmv.26832.
    Search in Google ScholarBack to article
  17. Fassio, A., Adami, G., Rossini, M., Giollo, A., Caimmi, C., Bixio, R., Viapiana, O., Milleri, S., Gatti, M., Gatti, D. (2020). Pharmacokinetics of oral cholecalciferol in healthy subjects with vitamin D deficiency: A randomized open-label study. Nutrients, 12 (6), 1553. DOI: 10.3390/nu12061553.
    Search in Google ScholarBack to article
  18. Fernandes, A. L., Murai, I. H., Reis, B. Z., Sales, L. P., Santos, M. D., Pinto, A. J., Goessler, K. F., Duran, C. S. C., Silva, C. B. R., Franco, A. S., et al. (2022). Effect of a single high dose of vitamin D3 on cytokines, chemokines, and growth factor in patients with moderate to severe COVID-19. Amer. J. Clin. Nutr., 115 (3), 790–798. DOI: 10.1093/ajcn/nqab426.
    Search in Google ScholarBack to article
  19. Güven, M., Gültekin H. (2021). The effect of high-dose parenteral vitamin D3 on COVID-19-related inhospital mortality in critical COVID-19 patients during intensive care unit admission: an observational cohort study. Eur. J. Clin. Nutr., 75 (9), 1383–1388. DOI: 10.1038/s41430-021-00984-5.
    Search in Google ScholarBack to article
  20. Hastie, C. E., Pell, J. P., Sattar, N. (2020). Vitamin D and COVID-19 infection and mortality in UK Biobank. Eur. J. Nutr., 60 (1), 545–548. DOI: 10.1007/s00394-020-02372-4.
    Search in Google ScholarBack to article
  21. Kappert K., Jahić A., Tauber R. (2020). Assessment of serum ferritin as a biomarker in COVID-19: Bystander or Pparticipant? Insights by comparison with other infectious and non-infectious diseases. Biomarkers, 25 (8), 616–625. DOI: 10.1080/1354750x.2020.1797880.
    Search in Google ScholarBack to article
  22. Kaufman, H. W., Niles, J. K., Kroll, M. H., Bi, C., Holick, M. F. (2020) SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PLoS One, 15 (9), e0239252. DOI: 10.1371/journal.pone.0239252.
    Search in Google ScholarBack to article
  23. Kruit, A., Zanen, P. (2016). The association between vitamin D and C-reactive protein levels in patients with inflammatory and non-inflammatory diseases. Clin. Biochem., 49 (7–8), 534–537. DOI: 10.1016/j.clinbiochem.2016.01.002.
    Search in Google ScholarBack to article
  24. Ling, S. F., Broad, E., Murphy, R., Pappachan, J. M., Pardesi-Newton, S., Kong, M. F., Jude, E. B. (2020). High-dose cholecalciferol booster therapy is associated with a reduced risk of mortality in patients with COVID-19: A cross-sectional multi-centre observational study. Nutrients, 12 (12), 3799. DOI: 10.3390/nu12123799.
    Search in Google ScholarBack to article
  25. Liu, G., Hong, T., Yang, J. (2020). A single large dose of vitamin D could be used as a means of coronavirus dsease 2019 prevention and treatment. Drug Des. Devel. Ther., 14, 3429–3434. DOI: 10.2147/DDDT.S271754.
    Search in Google ScholarBack to article
  26. Lv, Y., Chen, L., Liang, X., Liu, X., Gao, M., Wang, Q., Wei, Q., Liu, L. (2021). Association between iron status and the risk of adverse outcomes in COVID-19. Clin. Nutr., 40 (5), 3462–3469. DOI: 10.1016/j.clnu.2020.11.033.
    Search in Google ScholarBack to article
  27. Murai, I. H., Fernandes, A. L., Sales, L. P., Pinto, A. J., Goessler, K. F., Duran, C., Silva, C., Franco, A. S., Macedo, M. B., Dalmolin, H., et al. (2021). Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA, 325 (11), 1053–1060. DOI: 10.1001/jama.2020.26848.
    Search in Google ScholarBack to article
  28. Oristrell, J., Oliva, J. C., Casado, E., Subirana, I., Domķnguez, D., Toloba, A., Balado, A., Grau, M. (2021). Vitamin D supplementation and COVID-19 risk: A population-based, cohort study. J. Endocrinol Invest., 45 (1), 167–179. DOI: 10.1007/s40618-021-01639-9.
    Search in Google ScholarBack to article
  29. Pal, R., Banerjee, M., Bhadada, S. K., Shetty, A. J., Singh, B., Vyas, A. (2022). Vitamin D supplementation and clinical outcomes in COVID-19: A systematic review and meta-analysis. J. Endocrinol. Invest., 45 (1), 53–68. DOI: 10.1007/s40618-021-01614-4.
    Search in Google ScholarBack to article
  30. Radujkovic. A., Hippchen. T., Tiwari-Heckler. S., Dreher. S., Boxberger. M., Merle. U. (2020). Vitamin D deficiency and outcome of COVID-19 patients. Nutrients, 12 (9), 2757. DOI: 10.3390/nu12092757.
    Search in Google ScholarBack to article
  31. Rastogi, A., Bhansali, A., Khare, N., Suri, V., Yaddanapudi, N., Sachdeva, N., Puri, G. D., Malhotra P. (2022). Short term, high-dose vitamin D supplementation for COVID-19 disease: A randomised, placebo-controlled, study (SHADE study). Postgrad. Med. J., 98 (1156), 87–90. DOI: 10.1136/postgradmedj-2020-139065.
    Search in Google ScholarBack to article
  32. Ruscitti, P., Berardicurti, O., Di Benedetto, P., Cipriani, P., Iagnocco, A., Shoenfeld, Y., Giacomelli, R. (2020). Severe COVID-19, another piece in the puzzle of the hyperferritinemic syndrome. An immunomodulatory perspective to alleviate the storm. Front. Immunol., 11, 1130. DOI: 10.3389/fimmu.2020.01130.
    Search in Google ScholarBack to article
  33. Sabico, S., Enani, M. A., Sheshah, E., Aljohani, N. J., Aldisi, D. A., Alotaibi, N. H., Alshingetti, N., Alomar, S. Y., Alnaami, A. M., Amer, O. E., Hussain S. D., Al-Daghri, N. M. (2021). Effects of a 2-week 5000 IU versus 1000 IU vitamin D3 supplementation on recovery of symptoms in patients with mild to moderate COVID-19: A randomized clinical trial. Nutrients, 13 (7), 2170. DOI: 10.3390/nu13072170.
    Search in Google ScholarBack to article
  34. Sadeghi-Haddad-Zavareh, M., Bayani, M., Shokri, M., Ebrahimpour, S., Babazadeh, A., Mehraeen, R., Moudi, E., Rostami, A., Barary, M., Hosseini, A., Bijani, A., Javanian, M. (2021). C-Reactive protein as a pognostic indicator in COVID-19 patients. Interdiscip. Perspect. Infect Dis., 2021, 5557582. DOI: 10.1155/2021/5557582.
    Search in Google ScholarBack to article
  35. Sánchez-Zuno, G. A., González-Estevez, G., Matuz-Flores, M. G., Macedo-Ojeda, G., Hernández-Bello, J., Mora-Mora, J. C., Pérez-Guerrero, E. E., Garcķa-Chagollán, M., Vega-Magańa, N., Turrubiates-Hernández, F. J., et al. (2021). Vitamin D levels in COVID-19 outpatients from Western Mexico: Clinical correlation and effect of its supplementation. J. Clin. Med., 10 (11). DOI: 10.3390/jcm10112378.
    Search in Google ScholarBack to article
  36. Singh, R. P., Chauhan, K., Tripathi, A., Chaudhary (2021). E. Vitamin D and COVID-19 - Let's explore the relationship! Maedica, 16 (4), 628–633. DOI: 10.26574/maedica.2021.16.4.628.
    Search in Google ScholarBack to article
  37. Sulli, A., Gotelli, E., Casabella, A., Paolino, S., Pizzorni, C., Alessandri, E., Grosso, M., Ferone, D., Smith, V., Cutolo, M. (2021) Vitamin D and lung outcomes in elderly COVID-19 patients. Nutrients, 13 (3), 717. DOI: 10.3390/nu13030717.
    Search in Google ScholarBack to article
  38. Taneri, P. E., Gómez-Ochoa, S. A., Llanaj, E., Raguindin, P. F., Rojas, L. Z., Roa-Díaz, Z. M., Salvador, D., Groothof, D., Minder, B., Kopp-Heim, D., et al. (2020). Anemia and iron metabolism in COVID-19: A systematic review and meta-analysis. Eur. J. Epidemiol, 35 (8), 763–773. DOI: 10.1007/s10654-020-00678-5.
    Search in Google ScholarBack to article
  39. Tao, R. X., Zhou, Q. F., Xu, Z. W., Hao, J. H., Huang, K., Mou, Z., Jiang, X. M., Tao, F. B., Zhu, P. (2015). Inverse correlation between vitamin D and C-reactive protein in newborns. Nutrients, 7 (11), 9218–9228. DOI: 10.3390/nu7115468.
    Search in Google ScholarBack to article
  40. Teama, M. A. E. M., Abdelhakam, D. A., Elmohamadi, M. A., Badr, F. M. (2021). Vitamin D deficiency as a predictor of severity in patients with COVID-19 infection. Sci. Prog., 104, 368504211036854. DOI: 10.1177/00368504211036854.
    Search in Google ScholarBack to article
  41. Xu, Y., Baylink, D. J., Chen, C. S., Reeves, M. E., Xiao, J., Lacy, C., Lau, E., Cao, H. (2020). The importance of vitamin D metabolism as a potential prophylactic, immunoregulatory and neuroprotective treatment for COVID-19. J. Transl. Med., 18 (1), 322. DOI: 10.1186/s12967-020-02488-5
    Search in Google ScholarBack to article
  42. Zughaier, S. M., Alvarez, J. A., Sloan, J. H., Konrad, R. J., Tangpricha, V. (2014). The role of vitamin D in regulating the iron-hepcidin-ferroportin axis in monocytes. J. Clin. Transl. Endocrinol., 1, e19–e25. DOI: 10.1016/j.jcte.2014.01.003.
    Search in Google ScholarBack to article
DOI: https://doi.org/10.2478/prolas-2023-0021 | Journal eISSN: 2255-890X | Journal ISSN: 1407-009X
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Language: English
Page range: 153 - 161
Submitted on: Jun 28, 2023
Accepted on: Aug 8, 2023
Published on: Sep 28, 2023
Published by: Latvian Academy of Sciences
In partnership with: Paradigm Publishing Services
Publication frequency: 6 issues per year
Keywords:
Vitamin D insufficiency,
sublingual sprayable microemulsion,
inflammatory markers
Related subjects:
General interest,
Mathematics,
General mathematics

© 2023 Sintija Sauša, Svjatoslavs Kistkins, Lelde Krūzmane, Daina Kalniņa, Betija Jurģe, Kristīne Ivanova, Zane Svikle, Aija Frīdvalde, Valērija Roškova, Rebeka Elīza Zariņa, Terēze Treimane, Kristīne Geldnere, Ilva Trapiņa, Valdis Pīrāgs, published by Latvian Academy of Sciences
This work is licensed under the Creative Commons Attribution 4.0 License.

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