Study of Impact of a 1,4-DHP Derivative Glutapyrone on DNA Using In Vitro Tests

Elīna Ļeonova; Kristīne Dišlere; Evita Rostoka; Larisa Baumane; Egils Bisenieks; Gunārs Duburs; Nikolajs Sjakste

doi:10.2478/prolas-2023-0006

.blurhash-client-img { display: none !important; }

Study of Impact of a 1,4-DHP Derivative Glutapyrone on DNA Using In Vitro Tests

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

Volume 77 (2023): Issue 1 (February 2023)

By: Elīna Ļeonova, Kristīne Dišlere, Evita Rostoka, Larisa Baumane, Egils Bisenieks, Gunārs Duburs and Nikolajs Sjakste

Open Access

|Mar 2023

Abstract

The goal of the study was to test the ability of a representative of the 1,4-DHP group — glutapyrone to protect DNA against damage. The compound increased the concentration of the hydroxyl radicals produced in the Fenton reaction, it did not scavenge peroxynitrite and did not protect plasmid DNA against damage by products of the Fenton reaction. On the other hand, the compound protected HeLa cells against damage by peroxinitrite and B-lymphocytes against DNA damage in the conditions of oxidative stress induced by transfection of the Tat protein derived from the HIV virus. It is supposed that glutapyrone mobilises DNA repair systems.

References

Buraka, E., Chen, C. Y., Gavare, M., Grube, M., Makarenkova, G., Nikolajeva V., Bisenieks, I., Brūvere, I., Bisenieks, E., Duburs, G., Sjakste, N. (2014). DNA-binding studies of AV-153, an antimutagenic and DNA repair-stimulating derivative of 1,4-dihydropiridine. Chem. Biol. Interact., 220, 200–207.10.1016/j.cbi.2014.06.02725016077
Search in Google Scholar Back to article
Dišlere, K., Rostoka, E., Bisenieks, E., Duburs, G., Paramonova, N., Sjakste, N. (2021). 1,4-dihydropyridine derivatives increase mRNA expression of Psma3, Psmb5, and Psmc6 in rats. Arh. Hig. Rada Toksikol., 72 (3), 148–156.10.2478/aiht-2021-72-3422826520234187104
Search in Google Scholar Back to article
El-Amine, R., Germini, D., Zakharova, V. V., Tsfasman, T., Sheval, E. V., Louzada, R. A. N., Dupuy, C., Bilhou-Nabera, C., Hamade, A., Najjar, F., Oksenhendler, E., Lipinski, M., Chernyak, B. V., Vassetzky, Y. S. (2018). HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production. Redox Biol., 15, 97–108.10.1016/j.redox.2017.11.024572528029220699
Search in Google Scholar Back to article
Goncharova, R., Zabrejko, S., Dalivelya, O., Kuzhir, T. (2001) Anticlastogenicity of two derivatives of 1,4-dihydroisonicotinic acid in mouse micronucleus test. Mutat Res., 496 (1–2), 129–35.10.1016/S1383-5718(01)00223-6
Search in Google Scholar Back to article
Leonova, E., Ošiņa, K., Duburs, G., Bisenieks, E., Germini, D., Vassetzky, Y., Sjakste, N. (2019). Metal ions modify DNA-protecting and mutagen-scavenging capacities of the AV-153 1,4-dihydropyridine. Mutat. Res., 845, 403077.10.1016/j.mrgentox.2019.06.00731561891
Search in Google Scholar Back to article
Leonova, E., Rostoka, E., Baumane, L., Borisovs, V., Smelovs, E., Bisenieks, I., Brūvere, I., Bisenieks, E., Duburs, G., Sjakste, N. (2018a). DNA-binding studies of a series of novel water-soluble derivatives of 1,4-dihydropyridine. Biopolymers and Cell, 34 (2), 129–142.10.7124/bc.000977
Search in Google Scholar Back to article
Leonova, E., Rostoka, E., Sauvaigo, S., Baumane, L., Selga, T., Sjakste, N. (2018b). Study of interaction of antimutagenic 1,4-dihydropyridine AV-153-Na with DNA-damaging molecules and its impact on DNA repair activity. Peer J., 6, e4609.10.7717/peerj.4609592321429713564
Search in Google Scholar Back to article
Misane, I., Klusa, V., Dambrova, M., Germane, S., Duburs, G., Bisenieks, E., Rimondini, R., Ogren, S. O. (1998). “Atypical” neuromodulatory profile of glutapyrone, a representative of a novel “class” of amino acid-containing dipeptide-mimicking 1,4-dihydropyridine (DHP) compounds: in vitro and in vivo studies. Eur. Neuropsychopharmacol., 8 (4), 329–347.10.1016/S0924-977X(97)00097-79928926
Search in Google Scholar Back to article
Ošiņa, K. (2019). The effect of 1,4-dihydropyridine derivatives on expression of DNA repair and proteolysis enzymes in diabetes mellitus and the level of DNA breaks in vitro. Doctoral dissertation, University of Latvia, Rīga, Latvia. https://dspace.lu.lv/dspace/handle/7/48880 (accessed 12.01.2023).
Search in Google Scholar Back to article
Ošiņa, K., Rostoka, E., Sokolovska, J., Paramonova, N., Bisenieks, E., Duburs, G., Sjakste N, Sjakste T. (2016). 1,4-Dihydropyridine derivatives without Ca2+-antagonist activity up-regulate Psma6 mRNA expression in kidneys of intact and diabetic rats. Cell Biochem. Funct., 34 (1), 3–6.10.1002/cbf.316026634809
Search in Google Scholar Back to article
Pupure, J., Isajevs, S., Gordjushina, V., Taivans, I., Rumaks, J., Svirskis, S., Kratovska, A., Dzirkale, Z., Pilipenko, J., Duburs, G., Klusa, V. (2008). Distinct influence of atypical 1,4-dihydropyridine compounds in azidothymidine-induced neuro- and cardiotoxicity in mice ex vivo. Basic Clin. Pharmacol. Toxicol., 103 (5), 401–406.10.1111/j.1742-7843.2008.00221.x18801031
Search in Google Scholar Back to article
Velena, A., Skujiņs, A., Svirskis, S., Bisenieks, E., Uldriķis, J., Poikans, J., Duburs, G., Klusa, V. (1997). Modification of swelling-contraction-aggregation processes in rat muscle mitochondria by the 1,4-dihydropyridines, cerebrocrast and glutapyrone, themselves and in the presence of azidothymidine. Cell Biochem. Funct., 15 (3), 211–220.10.1002/(SICI)1099-0844(199709)15:3<211::AID-CBF743>3.0.CO;2-L
Search in Google Scholar Back to article

Articles in this issue

DOI: https://doi.org/10.2478/prolas-2023-0006 | Journal eISSN: 2255-890X | Journal ISSN: 1407-009X

Journal RSS Feed

Language: English

Page range: 49 - 52

Submitted on: Apr 25, 2022

Accepted on: Nov 10, 2022

Published on: Mar 9, 2023

Published by: Latvian Academy of Sciences

In partnership with: Paradigm Publishing Services

Publication frequency: 6 issues per year

Keywords:

Related subjects:

© 2023 Elīna Ļeonova, Kristīne Dišlere, Evita Rostoka, Larisa Baumane, Egils Bisenieks, Gunārs Duburs, Nikolajs Sjakste, published by Latvian Academy of Sciences
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 77 (2023): Issue 1 (February 2023)