Rar liver tumour — epithelioid haemangioendothelioma: a case report

Sniedze Laivacuma; Indra Zeltiņa; Aleksejs Derovs; Andris Norko; Sergejs Isajevs; Karīna Makejeva; Joost PH Drenth

doi:10.2478/prolas-2022-0103

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Rar liver tumour — epithelioid haemangioendothelioma: a case report

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

Volume 76 (2022): Issue 5-6 (December 2022)

By: Sniedze Laivacuma, Indra Zeltiņa, Aleksejs Derovs, Andris Norko, Sergejs Isajevs, Karīna Makejeva and Joost PH Drenth

Open Access

|Dec 2022

Abstract

Epithelioid haemangioendothelioma (EHE) is a rare vascular soft tissue malignant tumour with unknown etiology; the estimated prevalence of EHE is less than one in 1 million. A 56-year-old man was admitted in our department due to pain in the right side of the abdomen lasting for two years and weight loss up to 10 kg. Since 2012, the patient underwent lung and abdominal CT scanning as well as biopsy, however the diagnosis was challenging. In 2015, repeated abdominal CT scanning and a liver core biopsy was performed. The epithelioid haemangioendothelioma was diagnosed based by histopathological examination with subsequent radiological and clinical correlation. Therefore, accurate histopathological examination with radiological and clinical correlation is essential in the diagnosis of epithelioid haemangioendothelioma.

References

Antonescu, C. (2014). Malignant vascular tumors — an update. Mod. Pathol., 27, S30–S38. DOI:10.1038/modpathol.2013.176.10.1038/modpathol.2013.17624384851
Search in Google Scholar Back to article
Campione, S., Cozzolino, I., Mainenti, P., D'Alessandro, V., Vetrani, A., D'Armiento, M. (2015). Hepatic epithelioid hemangioendothelioma: Pitfalls in the diagnosis on fine needle cytology and “small biopsy” and review of the literature. Pathol. Res. Pract., 211 (9), 702–705. DOI: 10.1016/j.prp.2015.06.009.10.1016/j.prp.2015.06.00926187370
Search in Google Scholar Back to article
Choi, K. H., Moon, W. S. (2013). Epithelioid hemangioendothelioma of the liver. Clin. Mol. Hepatol., 19 (3), 315–319. DOI: 10.3350/cmh.2013.19.3.315.10.3350/cmh.2013.19.3.315379668324133671
Search in Google Scholar Back to article
Fletcher, C. D. M., Bridge, J. A., Hogendoorn, P., Mertens, F. (2013). WHO Classification of Tumours of Soft Tissue and Bone. Fourth Edition. IARC.
Search in Google Scholar Back to article
Gupta, R., Mathur, S. R., Gupta, S. D., Duirgapal, P., Iyer, V. K., Das, C. J., Shalimar, Acharya, S. K. (2009). Hepatic epithelioid hemangioendothelioma: A diagnostic pitfall in aspiration cytology. Cyto J., 6, 25. DOI: 10.4103/1742-6413.58951.10.4103/1742-6413.58951282218020165548
Search in Google Scholar Back to article
Jiang, L. I. N., Yuan, J. I. (2010). CT and MRI diagnosis of hepatic epithelioid hemangioendothelioma. Hepatobiliary Pancreat. Dis. Int., 9.2, 154–158. DOI: 10.3892/ol.2016.4149.10.3892/ol.2016.4149477443026998064
Search in Google Scholar Back to article
Jurczyk, M., Zhu, B., Laskin, W., Lin, X. (2014). Pitfalls in the diagnosis of hepatic epithelioid hemangioendothelioma by FNA and needle core biopsy. Diagn. Cytopathol., 42 (6), 516–520. DOI: 10.1002/dc.22943.10.1002/dc.2294323288560
Search in Google Scholar Back to article
Konstantinidis, I. T., Nota, C., Jutric, Z., Ituarte, P., Chow, W., Chu, P., Singh, G., Warner, S. G., Melstrom, L. G., Fong, Y. (2018). Primary liver sarcomas in the modern era: Resection or transplantation? J. Surg. Oncol., 117 (5), 886–891. DOI: 10.1002/jso.24979.10.1002/jso.24979599210129355969
Search in Google Scholar Back to article
Kubo, N., Harimoto, N., Araki, K., Hagiwara, K., Yamanaka, T., Ishii, N., Tsukagoshi, M., Igarashi, T., Watanabe, A., Miyazaki, M., Yokoo, H., Kuwano, H., Shirabe, K. (2018). The feature of solitary small nodular type of hepatic epithelioid hemangioendothelioma. Case Rep. Gastroenterol., 12 (2), 402–410. DOI: 10.1159/000490524.10.1159/000490524612040430186092
Search in Google Scholar Back to article
Lerut, J., Iesari, S. (2018). Vascular tumours of the liver: A particular story. Transl. Gastroenterol. Hepatol., 14 (3), 62. DOI: 10.21037/tgh.2018.09.02.10.21037/tgh.2018.09.02618201230363746
Search in Google Scholar Back to article
Llueca, A., Piquer, D., Maazouzi, Y., Medina, C., Delgado, K., Serra, A., Escrig, J. (2018). Hepatic epithelioid hemangioendothelioma: A great mimicker. Int. J. Surg. Case Rep., 53, 25–28. DOI: 10.1016/j.ijscr.2018.10.013.10.1016/j.ijscr.2018.10.013620514630366173
Search in Google Scholar Back to article
Lyburn, I. D., Torreggiani, W. C., Harris, A. C., Zwirewich, C. W., Buckley, A. R., Davis, J. E., Chung, S. W., Scudamore, C. H., Ho, S. G. F. (2003). Hepatic epithelioid hemangioendothelioma: Sonographic, CT, and MR imaging appearances. Amer. J. Roentgenol., 180 (5), 1359–1364. DOI: 10.2214/ajr.180.5.1801359.10.2214/ajr.180.5.1801359
Search in Google Scholar Back to article
Makhouf, H. R., Ishak, K. G., Goodman, Z. D. (1999). Epithelioid hemangioendothelioma of the liver. A clinicopathologic study of 137 cases. Cancer, 85 (3), 562–582. DOI: 10.1002/(sici)1097-0142(19990201)85:3<562::aid-cncr7>3.0.co;2-t.10.1002/(SICI)1097-0142(19990201)85:3<562::AID-CNCR7>3.0.CO;2-T
Search in Google Scholar Back to article
Mehrabi, A., Kashfi, A., Fonouni, H., Schemmer, P., Schmied, B. M., Hallscheidt, P., Schirmacher, P., Weitz, J., Friess, H., Buchler, M. W., Schmidt, J. (2006). Primary malignant hepatic epithelioid hemangioendothelioma. A comprehensive review of the literature with emphasis on the surgical therapy. Cancer, 107 (9), 2108–2121. DOI: 10.1002/cncr.22225.10.1002/cncr.22225
Search in Google Scholar Back to article
Neofytou, K., Chrysochos, A., Charalambous, N., Dietis, M., Petridis, C., Andreou, C., Petrou, A. (2013). Hepatic epithelioid hemangioendothelioma and the danger of misdiagnosis: Report of a case. Case Rep. Oncol. Med., 2013, 243939. DOI: 10.1155/2013/243939.10.1155/2013/243939
Search in Google Scholar Back to article
Omerhodžić, I., Bilalović, N., Rovčanin, B., Imširović, B., Suljić, E., Rotim, A., Arnautović, K. (2018). Primary epithelioid hemangioendothelioma in the cerebellum: Case report with reference to drastic change in the who classification. Acta Clin. Croat., 57 (3), 570–576. DOI: 10.20471/acc.2018.57.03.21.10.20471/acc.2018.57.03.21
Search in Google Scholar Back to article
Sangro, B., Iñarrairaegui, M., Fernández-Ros, N. (2012). Malignant epithelioid hemangioendothelioma of the liver successfully treated with Sorafenib. Rare Tumors, 4 (2), e34. DOI:10.4081/rt.2012.e34.10.4081/rt.2012.e34
Search in Google Scholar Back to article
Sardaro, A., Bardoscia, L., Petruzzelli, M. F.., Portulari, M. (2014). Epithelioid hemangioendothelioma: An overview and update on a rare vascular tumor. Oncol Rev., 8, 259. DOI: 10.4081/oncol.2014.259.10.4081/oncol.2014.259
Search in Google Scholar Back to article
Shiba, S., Imaoka, H., Shioji, K., Suzuki, E., Horiguchi, S., Terashima, T., Kojima, Y., Okuno, T., Sukawa, Y., Tsuji, K., et al. (2018). Clinical characteristics of Japanese patients with epithelioid hemangioendothelioma: A multicenter retrospective study. BMC Cancer, 18 (1), 993. DOI: 10.1186/s12885-018-4934-0.10.1186/s12885-018-4934-0
Search in Google Scholar Back to article
Verma, S. K., Mitchell, D. G., Bergin, D. (2008). Case report: MRI diagnosis of multifocal epithelioid hemangioendothelioma of the liver. Indian J. Radiol. Imaging., 18 (3), 239–241. DOI: 10.4103/0971-3026.41837.10.4103/0971-3026.41837
Search in Google Scholar Back to article
Wang, J. K., Wu, Z. R., Su, F., Ma, W. J., Hu, H. J., Li, F. Y. (2018). Resectable single hepatic epithelioid hemangioendothelioma in the left lobe of the liver: A case report. Open Med. (Wars)., 13, 456–459. DOI: 10.1515/med-2018-0069.10.1515/med-2018-0069
Search in Google Scholar Back to article
Wu, X., Li, B., Zheng, C., Hong, T., He, X. (2019). Clinical characteristics of epithelioid hemangioendothelioma: A single-center retrospective study. Eur. J. Med. Res., 24 (1), 16. DOI: 10.1186/s40001-019-0375-8.10.1186/s40001-019-0375-8639402830819247
Search in Google Scholar Back to article
Zhang, L., Chen, X. J., Lee, J. M., Lin, S. S. (2018). Hepatic epithelioid hemangioendothelioma: Challenges in the preoperative diagnosis. Kaohsiung J. Med. Sci., 34 (11), 659–661. DOI: 10.1016/j.kjms.2018.04.009.10.1016/j.kjms.2018.04.00930392574
Search in Google Scholar Back to article

Articles in this issue

DOI: https://doi.org/10.2478/prolas-2022-0103 | Journal eISSN: 2255-890X | Journal ISSN: 1407-009X

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Language: English

Page range: 674 - 678

Published on: Dec 10, 2022

Published by: Latvian Academy of Sciences

In partnership with: Paradigm Publishing Services

Publication frequency: 6 issues per year

Keywords:

EHE,

vascular tumour,

epithelioid hemangioma

Related subjects:

General interest,

Mathematics,

General mathematics

© 2022 Sniedze Laivacuma, Indra Zeltiņa, Aleksejs Derovs, Andris Norko, Sergejs Isajevs, Karīna Makejeva, Joost PH Drenth, published by Latvian Academy of Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 76 (2022): Issue 5-6 (December 2022)