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Mental Disorders Following Covid-19 Infection: A Systematic Review of Acute and Long-Term Psychiatric Manifestations and Associated Brain Changes Cover

Mental Disorders Following Covid-19 Infection: A Systematic Review of Acute and Long-Term Psychiatric Manifestations and Associated Brain Changes

Open Access
|Jan 2021

References

  1. Abad, C., Fearday, A., Safdar, N. (2010). Adverse effects of isolation in hospitalised patients: A systematic review. J. Hosp. Infect.,76 (2), 97–102.10.1016/j.jhin.2010.04.027
  2. Ahmed, H., Patel, K., Greenwood, D. C., Halpin, S., Lewthwaite, P., Salawu, A., Eyre, L., Breen, A., O’Connor, R., Jones, A., Sivan, M. (2020). Long-term clinical outcomes in survivors of severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus outbreaks after hospitalisation or ICU admission: A systematic review and meta-analysis. J. Rehabil. Med.,52 (5), jrm00063.10.2340/16501977-2694
  3. Alam, S. B., Willows, S., Kulka, M., Sandhu, J. K. (2020). Severe acute respiratory syndrome coronavirus-2 may be an underappreciated pathogen of the central nervous system. Eur. J. Neurol.,27 (11), 2348–2360.10.1111/ene.14442
  4. Alhajjaj, A., Abduljaber, T., Alsadeq, Z., Alkhabbaz, F., Alobaidan, H., Saeed, F., Al-Jishi, J., Aljanobi, G. (2020). Psychological and mental health among isolated hospitalized suspected and confirmed COVID-19 patients, Qatif Central Hospital, Eastern Province, Saudi Arabia: A single-center descriptive study. Open J. Int. Med.,10, 245–255.10.4236/ojim.2020.103026
  5. Alkeridy, W. A., Almaghlouth, I., Alrashed, R., Alayed, K., Binkhamis, K., Alsharidi, A., Liu-Ambrose, T. (2020). A unique presentation of delirium in a patient with otherwise asymptomatic COVID-19. J. Amer. Geriatr. Soc.,68 (7), 1382–1384.10.1111/jgs.16536
  6. Amerio, A., Aguglia, A., Odone, A., Gianfredi, V., Serafini, G., Signorelli, C., Amore, M. (2020). Covid-19 pandemic impact on mental health of vulnerable populations. Acta Biomed.,91 (9-s), 95–96.
  7. Anonymous (2020). Worldometers.info. Available from: https://www.worldometers.info/coronavirus/ (accessed 14 October 2020).
  8. Anzalone, N., Castellano, A., Scotti, R., Scandroglio, A. M., Filippi, M., Ciceri, F., Tresoldi, M., Falini, A. (2020). Multifocal laminar cortical brain lesions: A consistent MRI finding in neuro-COVID-19 patients. J. Neurol.,267 (10), 2806–2809.10.1007/s00415-020-09966-2
  9. Bo, H.-X., Li, W., Yang, Y., Wang, Y., Zhang, Q., Cheung, T., Wu, X., Xiang, Y.-T. (2020). Posttraumatic stress symptoms and attitude toward crisis mental health services among clinically stable patients with COVID-19 in China. Psychol. Med., 1–2.
  10. Byrne, A., Zibin, T., O’Croinin, F. (1993). Viral infections and psychiatric illness. Can. J. Psychiatry,38 (9), 631.10.1177/070674379303800920
  11. Cebrian, J., Gonzalez-Martinez, A., Garcia-Blanco, M. J., Celdran-Vivancos, D., Palacios, E. L., Reig-Rosello, G., Casado-Fernandez, L., Vivancos, J., Gago-Veiga, A. B. (2020). Headache and impaired consciousness level associated with SARS-CoV-2 in CSF: A case report. Neurology,95 (6), 266–268.10.1212/WNL.0000000000010213
  12. Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J. A., Yu, T., Zhang, X., Zhang, L. (2020). Epidemio-logical and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. The Lancet,395 (10223), 507–513.10.1016/S0140-6736(20)30211-7
  13. Chen, X., Laurent, S., Onur, O. A., Kleineberg, N. N., Fink, G. R., Schweitzer, F., Warnke, C. (2020). A systematic review of neurological symptoms and complications of COVID-19. J. Neurol., 1–11.
  14. Cheng, S. K., Tsang, J. S., Ku, K. H., Wong, C. W., Ng, Y. K. (2004). Psychiatric complications in patients with severe acute respiratory syndrome (SARS) during the acute treatment phase: A series of 10 cases. Brit. J. Psychiatry,184, 359–360.10.1192/bjp.184.4.35915056583
  15. Davis, D. H., Muniz Terrera, G., Keage, H., Rahkonen, T., Oinas, M., Matthews, F. E., Cunningham, C., Polvikoski, T., Sulkava, R., MacLullich, A. M., Brayne, C. (2012). Delirium is a strong risk factor for dementia in the oldest-old: A population-based cohort study. Brain,135 (Pt 9), 2809–2816.10.1093/brain/aws190343702422879644
  16. Epstein, D., Andrawis, W., Lipsky, A. M., Ziad, H. A., Matan, M. (2020). Anxiety and suicidality in a hospitalized patient with COVID-19 infection. Eur. J. Case Rep. Intern. Med.,7 (5), 001651.10.12890/2020_001651721382232399450
  17. Ferner, R. E., Aronson, J. K. (2020). Chloroquine and hydroxychloroquine in Covid-19. Brit. Med. J.,369, 2369, m1432.10.1136/bmj.m143232269046
  18. Ferrando, S. J., Klepacz, L., Lynch, S., Tavakkoli, M., Dornbush, R., Baharani, R., Smolin, Y., Bartell, A. (2020). COVID-19 psychosis: A potential new neuropsychiatric condition triggered by novel coronavirus infection and the inflammatory response? Psychosomatics,61 (5), 551–555.10.1016/j.psym.2020.05.012723674932593479
  19. Fong, T. G., Tulebaev, S. R., Inouye, S. K. (2009). Delirium in elderly adults: diagnosis, prevention and treatment. Nat. Rev. Neurol., 5 (4), 210–220.10.1038/nrneurol.2009.24306567619347026
  20. Fu, L., Wang, B., Yuan, T., Chen, X., Ao, Y., Fitzpatrick, T., Li, P., Zhou, Y., Lin, Y.-F. et al. (2020). Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis. J. Inf.,80 (6), 656–665.10.1016/j.jinf.2020.03.041715141632283155
  21. Heurich, A., Hofmann-Winkler, H., Gierer, S., Liepold, T., Jahn, O., Pöhlmann, S. (2014). TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. J. Virol.,88 (2), 1293–1307.10.1128/JVI.02202-13391167224227843
  22. Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., Müller, M. A., Drosten, C., Pöhlmann, S. (2020). SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell,181 (2), 271–280.e8.10.1016/j.cell.2020.02.052710262732142651
  23. Hosseini, A. A., Shetty, A. K., Sprigg, N., Auer, D. P., Constantinescu, C. S. (2020). Delirium as a presenting feature in COVID-19: Neuroinvasive infection or autoimmune encephalopathy? Brain Behav. Immun.,88, 68–70.10.1016/j.bbi.2020.06.012728278932531427
  24. Hu, T., Liu, Y., Zhao, M., Zhuang, Q., Xu, L., He, Q. (2020). A comparison of COVID-19, SARS and MERS. Peer J., 8, e9725.10.7717/peerj.9725744308132879801
  25. Huang, Y., Zhou, H., Yang, R., Xu, Y., Feng, X., Gong, P. (2020). Clinical characteristics of 36 non-survivors with COVID-19 in Wuhan, China. medRxiv, 20029009.10.1101/2020.02.27.20029009
  26. Hübscher, A., Isenmann, S. (2016). Delir: Konzepte, Ätiologie und klinisches Management. Fortschr. Neurol. Psychiatr.,84 (4), 233–244 (in German).
  27. Kenna, H. A., Poon, A. W., de los Angeles, C. P., Koran, L. M. (2011). Psychiatric complications of treatment with corticosteroids: Review with case report. Psychiatry Clin. Neurosci.,65 (6), 549–560.10.1111/j.1440-1819.2011.02260.x22003987
  28. Leonardi, M., Padovani, A., McArthur, J. C. (2020). Neurological manifestations associated with COVID-19: A review and a call for action. J. Neurol.,267 (6), 1573–1576.10.1007/s00415-020-09896-z723839232436101
  29. Leung, K. S.-S., Ng, T. T.-L., Wu, A. K.-L., Yau, M. C.-Y., Lao, H.-Y., Choi, M.-P., Tam, K. K.-G., Lee, L.-K., Wong, B. K.-C., Ho, A. Y.-M. et al. (2020). A territory-wide study of early COVID-19 outbreak in Hong Kong community: A clinical, epidemiological and phylogenomic investigation. medRxiv, 20045740.10.1101/2020.03.30.20045740
  30. Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., G¸tzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ,339 (2009), b2700.10.1136/bmj.b2700271467219622552
  31. Lim, S. T., Janaway, B., Costello, H., Trip, S. A., Price, G. (2020). Persistent psychotic symptoms following Covid-19 disease. BJ Psych. Open, 6 (5), e105.
  32. Loades, M. E., Chatburn, E., Higson-Sweeney, N., Reynolds, S., Shafran, R., Brigden, A., Linney, C., McManus, M. N., Borwick, C., Crawley, E. (2020). Rapid systematic review: The impact of social isolation and loneliness on the mental health of children and adolescents in the context of COVID-19. J. Amer. Acad. Child Adolesc. Psychiatry., 59 (11), 1218–1239.e3.10.1016/j.jaac.2020.05.009726779732504808
  33. Lu, Y., Li, X., Geng, D., Mei, N., Wu, P. Y., Huang, C. C., Jia, T., Zhao, Y., Wang, D., Xiao, A., Yin, B. (2020). Cerebral micro-structural changes in COVID-19 patients: An MRI-based 3-month follow-up study. EClin. Med.,25, 100484.10.1016/j.eclinm.2020.100484739695232838240
  34. Majadas, S., Perez, J., Casado-Espada, N. M., Zambrana, A., Bullon, A., Roncero, C. (2020). Case with psychotic disorder as a clinical presentation of COVID-19. Psychiatry Clin. Neurosci.,74 (10), 551–552.10.1111/pcn.13107736176932639089
  35. Mawhinney, J. A., Wilcock, C., Haboubi, H., Roshanzamir, S. (2020). Neurotropism of SARS-CoV-2: COVID-19 presenting with an acute manic episode. Brit. Med. J. Case Rep.,13 (6), e236123.10.1136/bcr-2020-236123729866532540882
  36. McLoughlin, B. C., Miles, A., Webb, T. E., Knopp, P., Eyres, C., Fabbri, A., Humphries, F., Davis, D. (2020). Functional and cognitive outcomes after COVID-19 delirium. Eur. Geriatr. Med.,11 (5), 857–862.10.1007/s41999-020-00353-8735831732666303
  37. Menninger, K. A. (1994). Influenza and schizophrenia. An analysis of post-influenzal “dementia precox” as of 1918, and five years later further studies of the psychiatric aspects of influenza. 1926. Amer. J. Psychiatry,151 (6 Suppl), 182–187.
  38. Nalleballe, K., Reddy Onteddu, S., Sharma, R., Dandu, V., Brown, A., Jasti, M., Yadala, S., Veerapaneni, K., Siddamreddy, S., Avula, A., Kapoor, N., Mudassar, K., Kovvuru, S. (2020). Spectrum of neuropsychiatric manifestations in COVID-19. Brain Behav. Immun.,88, 71–74.10.1016/j.bbi.2020.06.020
  39. Nampoothiri, S., Sauve, F., Ternier, G., Fernandois, D., Coelho, C., Imbernon, M., Deligia, E., Perbet, R., Florent, V., Baroncini, M., Pasquier, F., Trottein, F., Maurage, C.-A., Mattot, V., Giacobini, P., Rasika, S., Prevot, V. (2020). The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis. bioRxiv, 139329.10.1101/2020.06.08.139329
  40. Parra, A., Juanes, A., Losada, C. P., Alvarez-Sesmero, S., Santana, V. D., Marti, I., Urricelqui, J., Rentero, D. (2020). Psychotic symptoms in COVID-19 patients. A retrospective descriptive study. Psychiatry Res.,291, 113254.
  41. Pascual-Goni, E., Fortea, J., Martinez-Domeno, A., Rabella, N., Tecame, M., Gomez-Oliva, C., Querol, L., Gomez-Anson, B. (2020). COVID-19- associated ophthalmoparesis and hypothalamic involvement. Neurol. Neuroimmunol. Neuroinflamm.,7 (5), doi: 10.1212/NXI.0000000000000823.10.1212/NXI.0000000000000823
  42. Paterson, R. W., Brown, R. L., Benjamin, L., Nortley, R., Wiethoff, S., Bharucha, T., Jayaseelan, D. L., Kumar, G., Raftopoulos, R. E., Zambreanu, L. et al. (2020). The emerging spectrum of COVID-19 neurology: Clinical, radiological and laboratory findings. Brain,143 (10), 3104–3120.10.1093/brain/awaa240
  43. Pfefferbaum, B., North, C. S. (2020). Mental health and the Covid-19 pandemic. New Engl. J. Med.,383 (6), 510–512.10.1056/NEJMp2008017
  44. Qi, D., Yan, X., Tang, X., Peng, J., Yu, Q., Feng, L., Yuan, G., Zhang, A., Chen, Y., Yuan, J. et al. (2020). Epidemiological and clinical features of 2019-nCoV acute respiratory disease cases in Chongqing municipality, China: A retrospective, descriptive, multiple-center study. medRxiv, 20029397.10.1101/2020.03.01.20029397
  45. Rabaan, A. A., Al-Ahmed, S. H., Haque, S., Sah, R., Tiwari, R., Malik, Y. S., Dhama, K., Yatoo, M. I., Bonilla-Aldana, D. K., Rodriguez-Morales, A. J. (2020). SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview. Infez. Med.,28 (2), 174–184.
  46. Rai, D., Garg, R. K., Malhotra, H. S., Verma, R., Jain, A., Tiwari, S. C., Singh, M. K. (2014). Acute confusional state/delirium: An etiological and prognostic evaluation. Ann. Indian Acad. Neurol.,17 (1), 30–34.
  47. Rajkumar, R. P. (2020). COVID-19 and mental health: A review of the existing literature. Asian J. Psychiatr.,52, 102066.10.1016/j.ajp.2020.102066
  48. Rogers, J. P., Chesney, E., Oliver, D., Pollak, T. A., McGuire, P., Fusar-Poli, P., Zandi, M. S., Lewis, G., David, A. S. (2020). Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: A systematic review and meta-analysis with comparison to the COVID-19 pandemic. Lancet Psychiatry,7 (7), 611–627.10.1016/S2215-0366(20)30203-0
  49. Salluh, J. I., Wang, H., Schneider, E. B., Nagaraja, N., Yenokyan, G., Damluji, A., Serafim, R. B., Stevens, R. D. (2015). Outcome of delirium in critically ill patients: Systematic review and meta-analysis. BMJ,350, h2538.10.1136/bmj.h2538445492026041151
  50. Sato, K., Mano, T., Iwata, A., Toda, T. (2020). Neuropsychiatric adverse events of chloroquine: A real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database. Biosci Trends,14 (2), 139–143.10.5582/bst.2020.0308232321905
  51. Severance, E. G., Dickerson, F. B., Viscidi, R. P., Bossis, I., Stallings, C. R., Origoni, A. E., Sullens, A., Yolken, R. H. (2011). Coronavirus immuno-reactivity in individuals with a recent onset of psychotic symptoms. Schizophr. Bull.,37 (1), 101–107.10.1093/schbul/sbp052
  52. Singhal, T. (2020). A review of Coronavirus Disease-2019 (COVID-19). Indian J. Pediatr., 87 (4), 281–286.10.1007/s12098-020-03263-6
  53. Song, E., Zhang, C., Israelow, B., Lu-Culligan, A., Prado, A. V., Skriabine, S., Lu, P., Weizman, O.-E., Liu, F., Dai, Y. et al. (2020). Neuroinvasion of SARS-CoV-2 in human and mouse brain. bioRxiv, 169946.10.1101/2020.06.25.169946
  54. Soysal, P., Kara, O. (2020). Delirium as the first clinical presentation of the coronavirus disease 2019 in an older adult. Psychogeriatrics,20 (5), 763–765.10.1111/psyg.12587
  55. Townsend, L., Dyer, A. H., Jones, K., Dunne, J., Kiersey, R., Gaffney, F., Connor, L., Mooney, A., Leavy, D., Ridge, K. et al. (2020). Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. medRxiv, 20164293.10.1371/journal.pone.0240784
  56. Varatharaj, A., Thomas, N., Ellul, M. A., Davies, N. W. S., Pollak, T. A., Tenorio, E. L., Sultan, M., Easton, A., Breen, G., Zandi, M. et al. (2020). Neurological and neuropsychiatric complications of COVID-19 in 153 patients: A UK-wide surveillance study. Lancet Psychiatry,7 (10), 875–882.10.1016/S2215-0366(20)30287-X
  57. Vindegaard, N., Benros, M. E. (2020). COVID-19 pandemic and mental health consequences: Systematic review of the current evidence. Brain Behav. Immun.,89, 531–542.10.1016/j.bbi.2020.05.048
  58. Wilkins, E. G., Ellis, M. E., Dunbar, E. M., Gibbs, A. (1988). Does isolation of patients with infections induce mental illness? J. Infect.,17 (1), 43–47.10.1016/S0163-4453(88)92308-0
  59. Yachou, Y., El Idrissi, A., Belapasov, V., Ait Benali, S. (2020). Neuro-invasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: Understanding the neurological manifestations in COVID-19 patients. Neurol. Sci.,41, 2657–2669.10.1007/s10072-020-04575-3738520632725449
  60. Zaim, S., Chong, J. H., Sankaranarayanan, V., Harky, A. (2020). COVID-19 and multiorgan response. Curr. Probl. Cardiol.,45 (8), 100618.10.1016/j.cpcardiol.2020.100618718788132439197
  61. Zhang, B., Zhou, X., Qiu, Y., Song, Y., Feng, F., Feng, J., Song, Q., Jia, Q., Wang, J. (2020). Clinical characteristics of 82 cases of death from COVID-19. PLoS One,15 (7), e0235458.10.1371/journal.pone.0235458734713032645044
  62. Zhang, J., Lu, H., Zeng, H., Zhang, S., Du, Q., Jiang, T., Du, B. (2020). The differential psychological distress of populations affected by the COVID-19 pandemic. Brain Behav. Immun.,87, 49–50.10.1016/j.bbi.2020.04.031715694632304883
  63. Zubair, A. S., McAlpine, L. S., Gardin, T., Farhadian, S., Kuruvilla, D. E., Spudich, S. (2020). Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of Coronavirus Disease 2019: A review. JAMA Neurol.,77 (8), 1018–1027.10.1001/jamaneurol.2020.2065748422532469387
DOI: https://doi.org/10.2478/prolas-2020-0053 | Journal eISSN: 2255-890X | Journal ISSN: 1407-009X
Language: English
Page range: 347 - 357
Submitted on: Nov 17, 2020
Accepted on: Nov 27, 2020
Published on: Jan 5, 2021
Published by: Latvian Academy of Sciences
In partnership with: Paradigm Publishing Services
Publication frequency: 6 issues per year

© 2021 Paale Ruben Fischer, Lubova Renemane, published by Latvian Academy of Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.