Risk Factor Analysis for Gout in the Latvian Population

Erika Nagle; Nellija Luksa; Georgijs Moisejevs; Linda Gailīte

doi:10.2478/prolas-2020-0002

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Risk Factor Analysis for Gout in the Latvian Population

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

Volume 74 (2020): Issue 1 (February 2020)

By: Erika Nagle, Nellija Luksa, Georgijs Moisejevs and Linda Gailīte

Open Access

|Feb 2020

Abstract

Gout (Gr. podagra) is a multifactorial pathology, which means that both genetic and environmental factors play a role in the aetiology of the disease. For these reasons, revealing risk factors could be of very high importance in prevention and treatment of gout. In the present study, we found that a major role in gout predisposition is played by specific alleles in the ABCG2 gene. The study used survey data for 43 gout patients and 99 healthy control individuals who were geno-typed for rs2231142. It was found that allelic variant rs2231142 in the ABCG2 gene had the strongest association with gout. Among other co-factors studied, sex, and increased body mass index were associated with gout.

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Articles in this issue

DOI: https://doi.org/10.2478/prolas-2020-0002 | Journal eISSN: 2255-890X | Journal ISSN: 1407-009X

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Language: English

Page range: 7 - 11

Submitted on: Dec 19, 2018

Accepted on: Jan 1, 2020

Published on: Feb 27, 2020

Published by: Latvian Academy of Sciences

In partnership with: Paradigm Publishing Services

Publication frequency: 6 issues per year

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© 2020 Erika Nagle, Nellija Luksa, Georgijs Moisejevs, Linda Gailīte, published by Latvian Academy of Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 74 (2020): Issue 1 (February 2020)