Have a personal or library account? Click to login
Difference in Markers of Microbial Translocation and Cell Apoptosis in HIV Monoinfected and HIV/HCV Coinfected Patients Cover

Difference in Markers of Microbial Translocation and Cell Apoptosis in HIV Monoinfected and HIV/HCV Coinfected Patients

Open Access
|Jul 2019

References

  1. Abad-Fernandez, M., Vallejo, A., Hernandez-Novoa, B., Diaz, L., Gutierrez, C., Madrid, N., Angeles Munoz, M., Moreno, S. (2013). Correlation between different methods to measure microbial translocation and its association with immune activation in long-term supressed HIV-1 infected individuals. J. Acquir. Immune Defic. Syndr., 64, 149–153.10.1097/QAI.0b013e31829a2f1224047967
  2. Albillos, A., de la Hera, A., Gonzalez, M., Moya, J.-L., Calleja, J.-L., Monserrat, J., Riuz-del-Arbol, L., Alvarez-Mon, M. (2003). Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement. Hepatology, 37 (1), 208–217.10.1053/jhep.2003.5003812500206
  3. Balagopal, A., Phil, F. H., Astemborski, J., Block, T. M., Mehta, A., Long, R., Kirk, G. D., Mehta, S. H., Cox, A. L., Thomas, D. L., Ray, S. C. (2008). Human immunodeficiency virus-related microbial translocation and progression of hepatitis C. Gastroenterology, 135 (1), 226–233.10.1053/j.gastro.2008.03.022264490318457674
  4. Balagopal, A., Gama, L., Franco, V., Russell, J. N., Quinn, J., Higgins, Y., Smeaton, L. M., Clements, J. E., Thomas, D. L., Gupta, A. (2012). Detection of microbial translocation in HIV and SIV infection using the Limulus amebocyte lysate assay is masked by serum and plasma. PLoS ONE, 7 (8), 1–8.10.1371/journal.pone.0041258340985222870212
  5. Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., Blazar, B. R., Rodriguez, B., Teixeira-Johnson, L., Landay, A., Martin, J. N., Hecht, F. M., Picker, L. J., Lederman, M. M., Deeks, S. G., Douek, D. C. (2006). Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nature Med., 12, 1365–1371.10.1038/nm151117115046
  6. Caradonna, L., Mastronardi, M. L., Magrone, T., Cozzolongo, R., Cuppone, R., Manghisi, O. G., Caccavo, D., Pellegrino, N. M., Amoroso, A., Jirillo, E., Amati, L. (2002). Biological and clinical significance of entotoxemia in the course of hepatitis C virus infection. Curr. Pharmaceut. Des., 8, 995–1005.10.2174/138161202460698311945146
  7. Chan, C. C., Hwang, S. J., Lee, F. Y., Wang, S. S., Chang, F. Y., Li, C. P., Chu, C. J., Lu, R. H., Lee, S. D. (1997). Prognostic value of plasma endotoxin levels in patients with cirrhosis. Scand. J. Gastroenterol., 32 (9), 942–945.10.3109/003655297090112069299675
  8. Crane, M., Iser, D., Lewin, S. R. (2012). Human immunodeficiency virus infection and the liver. World J. Hepatol., 4 (3), 91–98.10.4254/wjh.v4.i3.91332149522489261
  9. Dinh, D. M., Volpe, G. E., Duffalo, C., Bhalchandra, S., Tai, A. K., Kane, A. V., Wanke, C. A., Ward, H. D. (2015). Intestinal microbiota, microbial translocation, and systemic inflammation in chronic HIV infection. J. Infect. Dis., 211, 19–27.10.1093/infdis/jiu409432631625057045
  10. Epeldegui, M., Magpantay, L., Guo, Y., Halec, G., Cumberland, W. G., Yen, P. K., Macatangay, B., Margolick, J. B., Fositch, A. F., Wolinsky, S., Martinez-Maza, O., Hussain, S. K. (2018). A prospective study of serum microbial translocation biomarkers and risk of AIDS- related non- Hodgkin lymphoma. AIDS, 32 (7), 945–954.10.1097/QAD.0000000000001771586910929424776
  11. Epple, H.-J., Schneider, T., Troeger, H., Kunkel, D., Allers, K., Moos, V., Amasheh, M., Loddenkemper, C., Fromm, M., Zeitz, M., Schulzke, J.-D. (2009). Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV- infected patients. Gut, 58, 220–227.10.1136/gut.2008.15042518936106
  12. French, A., Evans, C. T., Agniel, D. M., Cohen, M. H., Peters, M., Landay, A. L., Desai, S. N. (2013). Microbial translocation and liver disease progression in women coinfected with HIV and hepatitis C virus. J. Infect. Dis., 208, 679–689.10.1093/infdis/jit225371990723687224
  13. Hansjee, N., Kaufmann, G. R., Strub, C., Weber, R., Battegay, M., Erb, P. (2004). Persistent apoptosis in HIV-1-infected individuals receiving potent antiretroviral therapy is associated with poor recovery of CD4 T lymphocytes. J. Acquir. Immune Defic. Syndr., 36, 671–677.10.1097/00126334-200406010-0000315167285
  14. Hatano, H. (2013). Immune activation and HIV persistence: Considerations for novel therapeutic interventions. AIDS, 8 (3), 211–216.10.1097/COH.0b013e32835f9788404148823454864
  15. Jiang, W., Lederman, M. M., Hunt, P., Sieg, S. F., Haley, K., Rodriguez, B., Landay, A., Martin, J., Sinclair, E., Asher, A. I., Deeks, S. G., Douek, D. C., Brenchley, J. M. (2009). Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J. Infect. Dis., 199 (8), 1177–1185.10.1086/597476272862219265479
  16. Jirillo, E., Amati, L., Caradonna, L., Greco, B., Cozzolongo, R., Cuppone, R., Piazzolla, G., Caccavo, D., Antonaci, S., Manghisi, O. G. (1998). Soluble (s) CD14 and plasmatic lipopolysaccharides (LPS) in patients with chronic hepatitis C before and after treatment with interferon (IFN)-α. Immunopharmacol. Immunotoxicol., 20 (1), 1–14.10.3109/089239798090348059543696
  17. Kronenberger, B., von Wagner, M., Herrmann, E., Mihm, U., Piiper, A., Sarrazin, C., Zeuzem, S. (2005). Apoptotic cytokeratin 18 neoepitopes in serum of patients with chronic hepatitis C. J. Viral Hepat.,12, 307–314.10.1111/j.1365-2893.2005.00594.x15850472
  18. Lopez-Cortes, L. F., Trujillo-Rodriguez, M., Baez-Palomo, A., Benmarzouk-Hidalgo, O. J., Dominguez-Molina, B., Milanes-Guisado, Y., Espinosa, N., Viciana, P., Gutierrez-Valencia, A. (2018). Eradication of hepatitis C virus (HCV) reduces immune activation, microbial trans-location, and the HIV DNA level in HIV/HCV-coinfected patients. J. Infect. Dis., 218 (4), 624–632.10.1093/infdis/jiy13629986086
  19. Macias, J., Japon, M. A., Saez, C., Palacios, R. B., Mira, J. A., Garcia-Garcia, J. A., Merchante, N., Vergara, S., Lozano, F., Gomez-Mateos, J., Pineda, J. A. (2005). Increased hepatocyte Fas expression and apoptosis in HIV and hepatitis C virus infection. J. Infect. Dis., 192, 1566–1576.10.1086/49173616206071
  20. Marchetti, G., Bellistri, G. M., Borghi, E., Tincati, C., Ferramosca, S., La Francesca, M., Morace, G., Gori, A., d`Arminio Monforte, A. (2008). Microbial translocation is associated with sustained failure in CD+ T-cell reconstitution in HIV-infected patients on long-term highly active anti-retroviral therapy. AIDS, 22, 2035–2044.10.1097/QAD.0b013e3283112d2918784466
  21. Marchetti, G., Cozzi-Lepri, A., Merlini, E., Bellistri, G. M., Castagna, A., Galli, M., Verrucchi, G., Antinori, A., Costantini, A., Giacometti, A., di Caro, A., D’arminio Monforte, A. (2011). Microbial translocation predicts disease progression of HIV- infected antiretroviral- naïve patients with high CD4+ cell count. AIDS, 25, 1385–1394.10.1097/QAD.0b013e3283471d1021505312
  22. Marchetti, G., Tincati, C., Silvestri, G. (2013). Microbial translocation in the pathogenesis of HIV infection and AIDS. Clin. Microbiol. Rev., 26, 2–18.10.1128/CMR.00050-12355366823297256
  23. Marquez, M., Romero-Cores, P., Montes-Oca, M., Martin-Aspas, A., Soto-Cardenas, M.-J., Guerrero, F., Fernandez-Gutierrez, C., Giron-Gonzalez, J.-A. (2015). Immune activation response in chronic HIV-infected patients: Influence of hepatitis C virus coinfection. PLoS ONE, 10 (3), 1–15.10.1371/journal.pone.0119568436159725775475
  24. Marks, M. A., Rabkin, C. S., Engels, E. A., Busch, E., Kopp, W., Rager, H., Goedert, J. J., Chaturvedi, A. K. (2012). Markers of microbial translocation and risk of AIDS-related lymphoma. AIDS, 27, 469–474.10.1097/QAD.0b013e32835c133323169327
  25. Mhawej, M.-J., Brunet-Francois, C., Fonteneau, R., Ernst, D., Ferre, V., Stan, G.-B., Raffi, F., Moog, C. H. (2009). Apoptosis characterizes immunological failure of HIV infected patients. Control Eng. Practice, 17, 798–804.10.1016/j.conengprac.2009.01.001
  26. Nien, H.-C., Hsu, S.-J., Su, T.-H., Yang, P.-J., Sheu, J.-C., Wang, J.-T., Chow, L.-P., Chen, C.-L., Kao, J.-H., Yang, W.-S. (2017). High serum lipopolysaccharide-binding protein level in chronic hepatitis C viral infection is reduced by anti-viral treatments. PLoS ONE, 12 (1), 1–11.10.1371/journal.pone.0170028524920628107471
  27. Novati, S., Sacchi, P., Cima, S., Zuccaro, V., Columpsi, P., Pagani, L., Filice, G., Bruno, R. (2015). General issues on microbial translocation in HIV-infected patients. Eur. Rev. Med. Pharmacol. Sci,, 19, 866–878.
  28. de Oliveira Pinto, L. M., Lecoeur, H., Ledru, E., Rapp, C., Patey, O., Gougeon, M.-L. (2002). Lack of control of T cell apoptosis under HAART. Influence of therapy regimen in vivo and in vitro. AIDS, 16, 329–339.10.1097/00002030-200202150-0000311834943
  29. Parfieniuk-Kowerda, A., Lapinski T. W., Rogalska-Plonska, M., Swiderska, M., Panasiuk, A., Jaroszewicz, J., Flisika, R. (2013). Serum cytochrome c and m30-neoepitope of cytokeratin-18 in chronic hepatitis C. Liver Int., 34, 544–550.10.1111/liv.1229723981197
  30. Roger, P.-M., Breittmayer, J.-P., Durant, J., Sanderson, F., Ceppi, C., Brignone, C., Cua, E., Clevenbergh, P., Fuzibet, J.-G., Pesce, A., Bernard, A., Dellamonica, P. (2002). Early CD4+ T cell recovery in human immunodeficiency virus-infected patients receiving effective therapy is related to a down-regulation of apoptosis and not to proliferation. J. Infect. Dis.,185, 463–470.10.1086/33857311865398
  31. Rohrbach, J., Stickel, F., Schmid, P., Thormann, W., Kovari, H., Scherrer, A., Gunthard, H. F., Vuichard, D., Cavassini, M., Ambrosioni, J., Bernasconi, E., Furrer, H., Rauch, A. (2013). Changes in biomarkers of liver disease during successful combination antiretroviral therapy in HIV-HCV-coinfected individuals. Antiviral Ther., 19, 149–159.10.3851/IMP268624036684
  32. Sandler, N. G., Wand, H., Roque, A., Law, M., Nason, M. C., Nixon, D. E., Pedersen, C., Ruxrungtham, K., Lewin, S. R., Emery, S., Neaton, J. D., Brenchley, J. M., Deeks, S. G., Sereti, I., Douek, D. C. (2011). Plasma levels of soluble CD14 independently predict mortality in HIV patients. J. Infect. Dis.,203, 780–790.10.1093/infdis/jiq118307112721252259
  33. Sandler, N. G., Douek, D. C. (2012). Microbial translocation in HIV infection: Causes, consequences and treatment opportunities. Nature Rev. Microbiol., 10, 655–666.10.1038/nrmicro284822886237
  34. Seidel, N., Volkmann, X., Langer, F., Flemming, P., Manns, M. P., Schulze-Osthoff, K., Bantel, H. (2005). The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum. Hepatology, 42, 113–120.10.1002/hep.2074715920717
  35. Vassallo, M., Mercie, P., Cottalorda, J., Ticchioni, M., Dellamonica, P. (2012). The role of lipopolysaccharide as a marker of immune activation in HIV-1 infected patients: A systematic literature review. Virology J., 9 (174), 1–8.10.1186/1743-422X-9-174349584822925532
DOI: https://doi.org/10.2478/prolas-2019-0048 | Journal eISSN: 2255-890X | Journal ISSN: 1407-009X
Language: English
Page range: 304 - 311
Submitted on: Oct 30, 2018
Accepted on: Feb 28, 2019
Published on: Jul 12, 2019
Published by: Latvian Academy of Sciences
In partnership with: Paradigm Publishing Services
Publication frequency: 6 issues per year

© 2019 Monta Madelāne, Angelika Krūmiņa, Raimonds Sīmanis, Ģirts Šķenders, Andrejs Ivanovs, Gunta Stūre, Ludmila Vīksna, published by Latvian Academy of Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.