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Osimertinib-Induced Toxic Epidermal Necrolysis  – A Case Report Cover

Osimertinib-Induced Toxic Epidermal Necrolysis – A Case Report

Open Access
|Dec 2024

References

  1. Lynch, T.J.; Bell, D.W.; Sordella, R.; Gurubhagavatula, S.; Okimoto, R.A.; Brannigan, B.W.; Harris, P.L.; Haserlat, S.M.; Supko, J.G.; Haluska, F.G.; et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 2004, 350, 2129–2139.
  2. Paez, J.G. EGFR Mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 2004, 304, 1497–1500.
  3. Mok, T.S.; Wu, Y.L.; Ahn, M.J.; Garassino, M.C.; Kim, H.R.; Ramalingam, S.S.; Shepherd, F.A.; He, Y.; Akamatsu, H.; Theelen, W.S.; et al. Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer. N. Engl. J. Med. 2016,
  4. Lerch, M.; Mainetti, C.; Beretta-Piccoli, B.T.; Harr, T. Current perspectives on stevens-johnson syndrome and toxic epidermal necrolysis. Clin. Rev. Allergy Immunol. 2017, 54, 147–176.
  5. Lin, Y.T.; Chu, C. Osimertinib-induced Stevens-Johnson syndrome in a patient with EGFR T790M mutation-positive non-small cell lung cancer. Lung Cancer 2019, 129, 110–111.
  6. Ko TM, et al. Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome. J Allergy Clin Immunol. 2011;128(6):1266–76.
  7. De Araujo E, et al. Death ligand TRAIL, secreted by CD1a + and CD14 + cells in blister fluids, is involved in killing keratinocytes in toxic epidermal necrolysis. Exp Dermatol. 2011; 20(2): 107–12.
  8. Mok TS, Wu YL, Ahn MJ et al. Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer. N Engl J Med 2017; 376: 629–640.
  9. Ohe, Y.; Imamura, F.; Nogami, N.; Okamoto, I.; Kurata, T.; Kato, T.; Sugawara, S.; Ramalingam, S.S.; Uchida, H.; Hodge,R.; etal. Osimertinib versus standard-of-care EGFR-TKI as first-line treatment for EGFRm advanced NSCLC: FLAURA Japanese subset. Jpn. J. Clin. Oncol. 2019, 49, 29–36.
  10. Yang JC, Ahn MJ, Kim DW et al. Osimertinib in pretreated T790M-positive advanced non-small-cell lung cancer: AURA study phase II extension compo nent. J Clin Oncol 2017; 35: 1288–1296.
  11. Goss G,Tsai CM, Shepherd FA et al. Osimertinib for pretreated EGFR Thr790Met-positive advanced non-small-cell lung cancer (AURA2): A multicentre, open-label, single-arm, phase 2 study. Lancet Oncol 2016; 17: 1643–1652.
  12. Soria JC, Ohe Y,Vansteenkiste J et al. Osimertinib in untreated EGFR-mutated advanced non small-cell lung cancer. N Engl J Med 2017; 378: 113–125.
  13. Kozuki, T. Skin problems and EGFR-tyrosine kinase inhibitor. Jpn. J. Clin. Oncol. 2016, 46, 291–298.
  14. Chung,W.H.; Hung, S.I.; Hong, H.S.; Hsih, M.S.; Yang, L.C.; Ho, H.C.; Wu, J.Y.; Chen, Y.T. Medical genetics: Amarker for Stevens-Johnson syndrome. Nature 2004, 428, 486.
  15. Khoo, A.; Foo, C. Toxic epidermal necrolysis in a burns centre: A 6-year review. Burns 1996, 22, 275–278.
  16. Roujeau, J.C.; Kelly, J.P.; Naldi, L.; Rzany, B.; Stern, R.S.; Anderson, T.; Auquier, A.; Bastuji-Garin, S.; Correia, O.; Locati, F.; et al. Medication use and the risk of stevens–johnson syndrome or toxic epidermal necrolysis. N. Engl. J. Med. 1995, 333, 1600–1608.
  17. Lonjou, C.; Thomas, L.; Borot, N.; Ledger, N.; De Toma, C.; LeLouet, H.; Graf, E.; Schumacher, M.; Hovnanian, A.; Mockenhaupt,M.; etal. AmarkerforStevens-Johnsonsyndrome: Ethnicitymatters. Pharm. J. 2006, 6, 265–268.
  18. Wang, J.; Cheng, X.; Lu, Y.; Zhou, B. A case report of toxic epidermal necrolysis associated with AZD-9291. Drug Des. Dev. Ther. 2018, 12, 2163–2167.
  19. Huang, J.J.; Ma, S.-X.; Hou, X.; Wang, Z.; Zeng, Y.D.; Qin, T.; Dinglin, X.X.; Chen, L.K. Toxic epidermal necrolysis related to AP (pemetrexed plus cisplatin) and gefitinib combination therapy in a patient with metastatic non-small cell lung cancer. Chin. J. Cancer 2015, 34, 94–98
  20. Doesch, J.; Debus, D.; Meyer, C.; Papadopoulos, T.; Schultz, E.S.; Ficker, J.H.; Brueckl, W. Afatinib-associated Stevens-Johnson syndrome in an EGFR-mutated lung cancer patient. Lung Cancer 2016 95, 35–38.
  21. Otsuka,T; Tanaka,A.;Azukizawa,H.; Sasaki,S.; Ishijima,M.; Matsuki,T.; Osa,A.; Nakatani,T.; Kuroyama,M.; Hirata, H.; et al. Successful treatment with gefitinib after Stevens–Johnson syndrome associated with afatinib therapy in apatient with adenocarcinoma of the lung. Int. Cancer Conf. J. 2016, 6, 38–41
  22. Rittberg R, Ho C, Wang Y. Acute Onset of a Life-Threatening Skin Toxicity Due to Osimertinib: Severe Psoriasis Versus Toxic Epidermal Necrolysis Cureus. 2022 Apr 26; 14(4): e24513.
  23. Yunhua Xu,, Yong Li, Jie Luo and Rong Tang Osimertinib-induced Keratitis and Secondary Toxic Epidermal Necrotic Drug Eruption- A Case Report and Literature Review Current Drug Safety, 2024, 19, 309–312.
DOI: https://doi.org/10.2478/prilozi-2024-0025 | Journal eISSN: 1857-8985 | Journal ISSN: 1857-9345
Language: English
Page range: 77 - 84
Published on: Dec 12, 2024
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:

© 2024 Simonida Crvenkova, Maja Popova, Labina Crvenkova, Antonija Lazarevska, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.