References
- 1. World Health Organization (WHO). Obesity and overweight fact sheet, http://www.who.int/mediacentre/factsheets/fs311/en/ (2017, accessed 9 November 2017).
- 2. Ng M, Fleming T, Robinson M, et al. Global, regional and national prevalence of overweight and obesity in children and adults 1980-2013: A systematic analysis. Lancet. 2014; 384(9945): 766-781.
- 3. Wabitsch M, Moss A, Kromeyer-Hauschild K. Unexpected plateauing of childhood obesity rates in developed countries. BMC Medicine. 2014; 12: 17.
- 4. Blüher S, Meigen C, Gausche R, et al. Age-specific stabilization in obesity prevalence in German children: a cross-sectional study from 1999 to 2008. Int J Pediatr Obes. 2011; 6(2-2): e199-206.
- 5. Ahluwalia N, Dalmasso P, Rasmussen M, et al. Trends in overweight prevalence among 11-, 13-and 15-year-olds in 25 countries in Europe, Canada and USA from 2002 to 2010. Eur J Public Health. 2015; 25(Suppl 2): 28-32.
- 6. Skinner AC, Skelton JA. Prevalence and trends in obesity and severe obesity among children in the United States, 1999-2012. JAMA Pediatr. 2014; 168(6): 561-6.
- 7. Kelly AS, Barlow SE, Rao G, et al. Severe obesity in children and adolescents: identification, associated health risks, and treatment approaches: a scientific statement from the American Heart Association. Circulation. 2013; 128(15): 1689-712.
- 8. Juonala M, Magnussen CG, Berenson GS, et al. Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med. 2011; 365(20): 1876-85.
- 9. Singh AS, Mulder C, Twisk JW, et al. Tracking of childhood overweight into adulthood: a systematic review of the literature. Obes Rev. 2008; 9(5): 474-88.10.1111/j.1467-789X.2008.00475.x
- 10. Weiss R, Kaufman FR. Metabolic complications of childhood obesity: identifying and mitigating the risk. Diabetes Care. 2008; 31(Suppl 2): S310-6.
- 11. Skinner AC, Perrin EM, Moss LA, et al. Cardiometabolic Risks and Severity of Obesity in Children and Young Adults. N Engl J Med. 2015; 373(14): 1307-17.
- 12. Makkes S, Renders CM, Bosmans JE, et al. Cardiometabolic risk factors and quality of life in severely obese children and adolescents in the Netherlands. BMC Pediatrics. 2013; 13: 62.
- 13. Salvatore D, Satnick A, Abell R, et al. The prevalence of abnormal metabolic parameters in obese and overweight children. J Parenter Enteral Nutr. 2014; 38(7): 852-5.
- 14. Li L, Pérez A, Wu LT, et al. Cardiometabolic Risk Factors among Severely Obese Children and Adolescents in the United States, 1999-2012. Child Obes. 2016; 12(1): 12-9.
- 15. Wolf AM, Buffington C, Beisiegel U. Comparison of metabolic risk factors between severely and very severely obese patients. Obesity. 2006; 14(12): 2177-83.
- 16. Barlow SE. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics. 2007; 120(Suppl 4): S164-92.
- 17. Krebs NF, Himes JH, Jacobson D, et al. Assessment of child and adolescent overweight and obesity. Pediatrics. 2007; 120(Suppl 4): S193–S228.
- 18. Patel DA, Srinivasan SR, Chen W, et al. Serum Alanine Aminotransferase and Its Association with Metabolic Syndrome in Children: The Bogalusa Heart Study. Metabolic Syndrome and Related Disorders. 2011; 9(3): 211-216.10.1089/met.2010.0086
- 19. Alberti KG, Zimmet PZ. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications Part 1 : Diagnosis and Classification of Diabetes Mellitus Provisional Report of a WHO Consultation. 1998; 15(7): 539-553.
- 20. Schwimmer JB, Dunn W, Norman GJ, et al. SAFETY study: Alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease. Gastroenterology. 2010; 138(4): 1357-1364.e2.
- 21. Soghier L, Pham K, Rooney S. Reference Range values for Pediatric Care. Elk Grove Village, IL: American Academy of Pediatrics 2014; 70.
- 22. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, National Heart, Lung, and Blood Institute. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents: summary report. Pediatrics. 2011; 128(Suppl 5): S213–S256.
- 23. American Diabetes Association. Classification and Diagnosis of Diabetes. Diabetes Care. 2016; 39(Suppl 1): S13-22.
- 24. van Emmerik NM, Renders CM, van de Veer M, et al. High cardiovascular risk in severely obese young children and adolescents. Arch Dis Child. 2012; 97(9): 818-21.10.1136/archdischild-2012-301877
- 25. Freedman DS, Mei Z, Srinivasan SR, et al. Cardiovascular risk factors and excess adiposity among overweight children and adolescents: the Bogalusa Heart Study. J Pediatr. 2007; 150(1): 12-17.e2.
- 26. Schönbeck Y, Talma H, van Dommelen P, et al. Increase in Prevalence of Overweight in Dutch Children and Adolescents: A Comparison of Nationwide Growth Studies in 1980, 1997 and 2009. PLoS ONE. 2011; 6(11): e27608.
- 27. Cook S, Kavey REW. Dyslipidemia and Pediatric Obesity. Pediatric clinics of North America. 2011; 58(6): 1363-1373.10.1016/j.pcl.2011.09.003
- 28. Smoak CG, Burke GL, Webber LS, et al. Relation of obesity to clustering of cardiovascular disease risk factors in children and young adults. The Bogalusa Heart Study. Am J Epidemiol. 1987; 125(3): 364-72.
- 29. Chen F, Wang Y, Shan X, et al. Association between Childhood Obesity and Metabolic Syndrome: Evidence from a Large Sample of Chinese Children and Adolescents. PLoS ONE. 2012; 7(10): e47380.
- 30. Codoñer-Franch P, Murria-Estal R, Tortajada-Girbés M, et al. New factors of cardiometabolic risk in severely obese children: influence of pubertal status. Nutr Hosp. 2010; 25(5): 845-51.
- 31. Rank M, Siegrist M, Wilks DC, et al. The cardio-metabolic risk of moderate and severe obesity in children and adolescents. J Pediatr. 2013; 163(1): 137-42.
- 32. Rocha T, Rocha E, Alves AC. Cardiovascular risk profile of high school students: a cross-sectional study. Rev Port Cardiol. 2014; 33(9): 525-34.
- 33. Maffeis C, Pinelli L, Brambilla P. Fasting plasma glucose (FPG) and the risk of impaired glucose tolerance in obese children and adolescents. Obesity. 2010; 18(7): 1437-42.10.1038/oby.2009.355
- 34. Valerio G, Maffeis C, Balsamo A, et al. Severe Obesity and Cardiometabolic Risk in Children: Comparison from Two International Classification Systems. PLoS ONE. 2013; 8(12): e83793.
- 35. Ling JCY, Mohamed MNA, Jalaludin MY, et al. Determinants of High Fasting Insulin and Insulin Resistance Among Overweight/Obese Adolescents. Scientific Reports. 2016; 6: 36270.
- 36. Hrafnkelsson H, Magnusson KT, Sigurdsson EL, et al. Association of BMI and fasting insulin with cardiovascular disease risk factors in seven-year-old Icelandic children. Scandinavian Journal of Primary Health Care. 2009; 27(3): 186-191.10.1080/02813430903155028
- 37. Lavine JE, Schwimmer JB. Nonalcoholic fatty liver disease in the pediatric population. Clin Liver Dis. 2004; 8(3): 549-58.10.1016/j.cld.2004.04.010
- 38. Strauss RS, Barlow SE, Dietz WH. Prevalence of abnormal serum aminotransferase values in over-weight and obese adolescents. J Pediatr. 2000; 136(6): 727-33.
- 39. Styne DM, Arslanian SA, Connor EL, et al. Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2017; 102(3): 709-757.
- 40. Di Bonito P, Sanguigno E, Di Fraia T, et al. Association of elevated serum alanine aminotransferase with metabolic factors in obese children: sex-related analysis. Metabolism. 2009; 58(3): 368-72.10.1016/j.metabol.2008.10.010