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BioFire® FilmArray® Pneumonia Panel versus bacterial culture in adult community acquired pneumonia: treatment implications Cover

BioFire® FilmArray® Pneumonia Panel versus bacterial culture in adult community acquired pneumonia: treatment implications

Open Access
|Oct 2025

References

  1. Martin-Loeches I, Torres A, Nagavci B, Aliberti S, Antonelli M, Bassetti M, et al. ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia. Intensive Care Medicine. 2023;49(6): 615–632. doi:10.1007/S00134-023-07033-8
  2. Yatera K, Mukae H. Corynebacterium species as one of the major causative pathogens of bacterial pneumonia. Respiratory Investigation. 2020;58: 131–133. doi:10.1016/J. RESINV.2020.01.008
  3. Foschi C, Zignoli A, Gaibani P, Vocale C, Rossini G, Lafratta S, et al. Respiratory bacterial co-infections in intensive care unit-hospitalized COVID-19 patients: conventional culture vs Biofire FilmArray Pneumonia Plus Panel. Journal of Microbiological Methods. 2021;186: 106259. doi:10.1016/J.MIMET.2021.106259
  4. Kamel NA, Alshahrani MY, Aboshanab KM, El Borhamy MI. Evaluation of the BioFire FilmArray Pneumonia Panel Plus to the conventional diagnostic methods in determining the microbiological etiology of hospital-acquired pneumonia. Biology (Basel). 2022;11: 377. doi:10.3390/BIOLOGY11030377/S1
  5. Musher DM, Roig IL, Cazares G, Stager CE, Logan N, Safar H. Can an etiologic agent be identified in adults who are hospitalized for community-acquired pneumonia: results of a one-year study. The Journal of Infection. 2013;67: 11–18. doi:10.1016/J. JINF.2013.03.003
  6. Jones BE, Ying J, Stevens V, Haroldsen C, He T, Nevers M, et al. Empirical anti-MRSA vs standard antibiotic therapy and risk of 30-day mortality in patients hospitalized for pneumonia. JAMA Internal Medicine. 2020;180: 552–560. doi:10.1001/JAMAINTERNMED.2019.7495
  7. Webb BJ, Sorensen J, Mecham I, Buckel W, Ooi L, Jephson A, et al. Antibiotic use and outcomes after implementation of the drug resistance in pneumonia score in ED patients with community-onset pneumonia. Chest. 2019;156: 843–851. doi:10.1016/J.CHEST.2019.04.093
  8. Corrigan RA, Sliepen J, Dudareva M, IJpma FFA, Govaert G, Atkins BL, et al. Causative pathogens do not differ between early, delayed or late fracture-related infections. Antibiotics (Basel, Switzerland). 2022;11: 943. doi:10.3390/ANTIBIOTICS11070943
  9. Yoo IY, Huh K, Shim HJ, Yun SA, Chung YN, Kang OK, et al. Evaluation of the BioFire FilmArray Pneumonia Panel for rapid detection of respiratory bacterial pathogens and antibiotic resistance genes in sputum and endotracheal aspirate specimens. International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases. 2020;95: 326–331. doi:10.1016/J.IJID.2020.03.024
  10. Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, et al. AMERICAN THORACIC SOCIETY Diagnosis and treatment of adults with community-acquired pneumonia an official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America. American Journal of Respiratory and Critical Care Medicine. 2019;200: E45–E67. doi:10.1164/rccm.201908-1581ST
  11. Rand KH, Beal SG, Cherabuddi K, Couturier B, Lingenfelter B, Rindlisbacher C, et al. Performance of a semiquantitative multiplex bacterial and viral PCR panel compared with standard microbiological laboratory results: 396 patients studied with the Biofire Pneumonia Panel. Open Forum Infectious Diseases. 2020;8: 1-8. doi:10.1093/ofid/ofaa560
  12. CDC Archive. Interim guidelines for collecting and handling of clinical specimens for COVID-19 testing [Im Internet]. 2025. Available from: https://archive.cdc.gov/#/details?url=https://www.cdc.gov/coronavirus/2019-ncov/lab/guidelines-clinical-specimens.html [Stand: 18th May 2025]
  13. Webber DM, Wallace MA, Burnham CD, Anderson NW.2020. Evaluation of the BioFire FilmArray Pneumonia Panel for Detection of Viral and Bacterial Pathogens in Lower Respiratory Tract Specimens in the Setting of a Tertiary Care Academic Medical Center. J Clin Microbiol 2020; 58:10. doi:10.1128/jcm.00343-20
  14. Buchan BW, Windham S, Balada-Llasat JM, Leber A, Harrington A, Relich R, Murphy C, et al., Practical comparison of the BioFire FilmArray pneumonia panel to routine diagnostic methods and potential impact on antimicrobial stewardship in adult hospitalized patients with lower respiratory tract infections. Journal of clinical microbiology. 2020 Jun 24;58(7):10-128.
  15. McHugh LC, Snyder K, Yager TD. The effect of uncertainty in patient classification on diagnostic performance estimations. PLoS One. 2019;14: e0217146. doi:10.1371/JOURNAL. PONE.0217146
  16. Jain S, Self WH, Wunderink RG, Fakhran S, Balk R, Bramley AM, et al. Community-acquired pneumonia requiring hospitalization among U.S. adults. The New England Journal of Medicine. 2015;373: 415–427. doi:10.1056/NEJMOA1500245
  17. Kuypers J, Loeffelholz MJ. Impact of rapid molecular detection of respiratory viruses on clinical outcomes and patient management. Journal of Clinical Microbiology. 2019;57: 1890–1908. doi:10.1128/JCM.01890-18
  18. Zhou F, Wang Y, Liu Y, Liu X, Gu L, Zhang X, et al. Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network. The European Respiratory Journal. 2019;54: 1802406. doi:10.1183/13993003.02406-2018
  19. Alimi Y, Lim WS, Lansbury L, Leonardi-Bee J, Nguyen-Van-Tam JS. Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe. Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology. 2017;95: 26–35. doi:10.1016/J. JCV.2017.07.019
  20. Burk M, El-Kersh K, Saad M, Wiemken T, Ramirez J, Cavallazzi R. Viral infection in community-acquired pneumonia: a systematic review and meta-analysis. European Respiratory Review. 2016;25: 178–188. doi:10.1183/16000617.0076-2015
  21. Shah NS, Greenberg JA, McNulty MC, Gregg KS, Riddell J, Mangino JE, et al. Bacterial and viral co-infections complicating severe influenza: incidence and impact among 507 U.S. patients, 2013–14. Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology. 2016;80: 12–19. doi:10.1016/J.JCV.2016.04.008
  22. Ramirez J, Peyrani P, Wiemken T, Chaves SS, Fry AM. A randomized study evaluating the effectiveness of oseltamivir initiated at the time of hospital admission in adults hospitalized with influenza-associated lower respiratory tract infections. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 2018;67: 736–742. doi:10.1093/CID/CIY163
  23. Jiang, Shan MDa; Liu, Tiecheng PhDb; Hu, Yuxin PhDa; Li, Ranwei PhDc; Di, Xin PhDd; Jin, Xin PhDd; Wang, Yanqiao MDa; Wang, Ke PhDa,*. Efficacy and safety of glucocorticoids in the treatment of severe community-acquired pneumonia: A meta-analysis. Medicine 2019; 98(26): p e16239. doi:10.1097/MD.0000000000016239
  24. Jiang S, Liu T, Hu Y, Li R, Di X, Jin X, et al. Efficacy and safety of glucocorticoids in the treatment of severe community-acquired pneumonia: a meta-analysis. Medicine (United States). 2019;98. doi:10.1097/MD.0000000000016239
  25. Niederman MS, Torres A. Severe community-acquired pneumonia. European Respiratory Review. 2022;31: 1–12. doi:10.1183/16000617.0123-2022
  26. Ferrer M, Travierso C, Cilloniz C, Gabarrus A, Ranzani OT, Polverino E, et al. Severe community-acquired pneumonia: characteristics and prognostic factors in ventilated and non-ventilated patients. PLoS One. 2018;13: 1–14. doi:10.1371/JOURNAL. PONE.0191721
DOI: https://doi.org/10.2478/pneum-2025-0027 | Journal eISSN: 2247-059X | Journal ISSN: 2067-2993
Language: English
Page range: 48 - 60
Published on: Oct 31, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: Volume open

© 2025 Samir Mohamed Mahmoud Fahyim, Hesham Atef AbdelHalim, Heba Helmy AboElNaga, Rania Talaat Abdel Haleem, El Shaimaa Sabry Mohammed Hassan, published by Romanian Society of Pneumology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.