Pathophysiology of paraneoplastic rheumatologic syndromes- could be involved in the diagnosis of a pulmonary adenocarcinoma?

Paraneoplastic syndromes are diseases caused by malignancies without direct anatomical relationship with it and it is crucial to realize that paraneoplastic phenomena are not caused by metastases. A paraneoplastic phenomenon can be the first indicator of cancer in an undiagnosed individual, and in severe cases lead to fatality. Various paraneoplastic rheumatological syndromes are associated with malignant neoplasms. Although they occur within various forms of malignancy, they most often suceed lung cancer, and adenocarcinoma stands out as the most prevalent histological subtype within pulmonary cancer. This article focuses on the understanding of paraneoplastic syndromes, particularly regarding paraneoplastic rheumatic syndromes due to their challenging differentiation from idiopathic rheumatic disorders.