ACE gene I/D polymorphism and arterial hypertension in patients with COPD Cover

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ACE gene I/D polymorphism and arterial hypertension in patients with COPD

Volume 68 (2019): Issue 3 (December 2019)

By: Mariya Marushchak, Khrystyna Maksiv and Inna Krynytska

Open Access

|Dec 2019

Figures & Tables

Hardy–Weinberg equilibrium of the ACE gene I/D polymorphism in COPD, AH and their combination

Genotype		COPD		AH		COPD + AH		Control

		Expected	Observed	Expected	Observed	Expected	Observed	Expected	Observed
Common homozygotes	I/I	7.8	7	7.3	7	8	9	6.1	5
Heterozygotes	I/D	14.6	14	11.3	12	13.9	12	9.9	12
Rare homozygotes	D/D	2.6	4	4.4	4	6.1	7	4	3
Chi-square, χ²		χ² = 0.86, df = 2, p > 0.05		χ² = 0.09, df = 2, p > 0.05		χ² = 0.52, df = 2, p > 0.05		χ² = 0.89, df = 2, p > 0.05

OR for alleles in different study groups

Group	Alleles

	ACE I allele			ACE D allele

	OR	95% CI	p	OR	95% CI	p
COPD	1.04	0.45–2.40	>0.05	0.96	0.42–2.22	>0.05
AH	1.06	0.45–2.50	>0.05	0.94	0.40–2.21	>0.05
COPD + AH	0.94	0.42–2.13	>0.05	1.26	0.47–2.39	>0.05

Allele frequencies of the ACE gene I/D polymorphism

Allele frequency	COPD		AH		COPD + AH		Control

	n	%	n	%	n	%	n	%
ACE I allele	28	56.0	26	56.5	30	53.6	22	55.0
ACE D allele	22	44.0	20	43.5	26	46.4	18	45.0
Pearson’s chi-square, χ² (disease/control group)	χ² = 0.01, df = 1, p = 0.92		χ² = 0.02, df = 1, p = 0.89		χ² = 0.02, df = 1, p = 0.89		–

Genotype frequencies of the ACE gene I/D polymorphism in COPD, AH and their combination

Genotype frequencies	COPD		AH		COPD + AH		Control

	n	%	n	%	n	%	n	%
I/I	7	28.0	7	30.4	9	32.1	5	25.0
I/D	14	56.0	12	52.2	12	42.9	12	60.0
D/D	4	16.0	4	17.4	7	25.0	3	15.0

Fisher’s exact p, two tailed (disease/control group)	p = 1.0		p = 0.75		p = 0.75		–

OR for genotypes in different study groups

Group	Genotype

	I/I		I/D		D/D

	OR	95% CI	OR	95% CI	OR	95% CI
COPD	1.17	0.31–4.44	0.85	0.26–2.80	1.08	0.21–5.50
AH	1.31	0.34–5.05	0.73	0.22–2.44	1.19	0.23–6.11
COPD + AH	1.42	0.39–5.14	0.50	0.16–1.61	1.89	0.42–8.43

DOI: https://doi.org/10.2478/pneum-2019-0039 | Journal eISSN: 2247-059X | Journal ISSN: 2067-2993

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Language: English

Page range: 114 - 119

Published on: Dec 9, 2019

Published by: Romanian Society of Pneumology

In partnership with: Paradigm Publishing Services

Publication frequency: Volume open

Keywords:

Cuvinte-cheiechronic obstructive pulmonary disease,

arterial hypertension,

angiotensin-converting enzyme gene,

insertion-deletion polymorphism

Related subjects:

Clinical medicine,

Clinical medicine, other,

Internal medicine,

© 2019 Mariya Marushchak, Khrystyna Maksiv, Inna Krynytska, published by Romanian Society of Pneumology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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