Association between arterial hypertension and chronic obstructive pulmonary disease: role of AGT gene polymorphism Cover

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Association between arterial hypertension and chronic obstructive pulmonary disease: role of AGT gene polymorphism

Volume 68 (2019): Issue 4 (December 2019)

By: Mariya Marushchak, Khrystyna Maksiv, Inna Krynytska and Kateryna Kozak

Open Access

|Mar 2020

Figures & Tables

OR for alleles in different study groups

Group	Alleles

	AGT M allele			AGT T allele

	OR	95% CI	p	OR	95% CI	p
COPD	0.90	0.38–2.11	>0.05	1.11	0.47–2.61	>0.05
AH	0.71	0.3–1.69	>0.05	1.4	0.59–3.32	>0.05
COPD + AH	0.56	0.24–1.28	>0.05	1.79	0.78–4.09	>0.05

A dominant model of AGT gene inheritance in combination of COPD and AH

Genotypes	COPD + AH	Control	χ²	p	OR	95% CI

	%	%
M/M genotype	25.0	30.0	0.15	0.7	0.78	0.22–2.81
M/T + T/T genotype	75.0	70.0	0.15	0.7	1.29	0.36–4.64

Genotype frequencies of the AGT gene M/T polymorphism in COPD, AH and their combination

Genotype frequencies	COPD		AH		COPD + AH		Control

	n	%	n	%	n	%	n	%
M/M	6	24.0	6	26.1	7	25.0	6	30.0
M/T	18	72.0	13	56.5	13	46.4	13	65.0
T/T	1	4.0	4	17.4	8	28.6	1	5.0
Fisher’s exact p (two-tailed; disease/control group)	p = 0.75		p = 0.76		p = 0.25		–

A recessive model of the AGT gene inheritance in combination of COPD and AH

Genotypes	COPD + AH	Control	χ²	p	OR	95% CI

	%	%
M/M + M/T genotype	71.4	95.0	4.25	0.04	0.13	0.01–1.15
T/T genotype	28.6	5.0	4.25	0.04	7.60	0.87–66.67

Hardy–Weinberg equilibrium of the AGT gene M/T polymorphism in COPD, AH and their combination

Genotype		COPD		AH		COPD + AH		Control

		Expected	Observed	Expected	Observed	Expected	Observed	Expected	Observed
Common homozygotes	M/M	9	6	6.8	6	6.5	7	7.8	6
Heterozygotes	M/T	11.8	18	11.4	13	14	13	9.4	13
Rare homozygotes	T/T	4.2	1	4.8	4	7.5	8	2.8	1
Chi-square		χ² = 6.70, df = 2, p < 0.04		χ² = 0.45, df = 2, p > 0.05		χ² = 0.14, df = 2, p > 0.05		χ² = 2.95, df = 2, p > 0.05

Allele frequencies of the AGT gene M/T polymorphism in COPD, AH and their combination

Allele frequency	COPD		AH		COPD + AH		Control

	n	%	n	%	n	%	n	%
AGT M allele	30	60.0	25	54.3	27	48.2	25	62.5
AGT T allele	20	40.0	21	45.7	29	51.8	15	37.5
Pearson chi-square (χ²; disease/control group)	χ² = 0.06, df = 1, p = 0.81		χ² = 0.58, df = 1, p = 0.44		χ² = 1.92, df = 1, p = 0.17		–

OR for genotypes in different study groups

Group	Genotype

	M/M		M/T		T/T

	OR	95% CI	OR	95% CI	OR	95% CI
COPD	0.74	0.20–2.77	1.38	0.39–4.92	0.79	0.05–13.5
AH	0.82	0.22–3.13	0.70	0.20–2.41	4.00	0.41–39.18
COPD + AH	0.78	0.22–2.81	0.47	0.14–1.52	7.60	0.87–66.67

DOI: https://doi.org/10.2478/pneum-2019-0036 | Journal eISSN: 2247-059X | Journal ISSN: 2067-2993

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Language: English

Page range: 174 - 182

Published on: Mar 31, 2020

Published by: Romanian Society of Pneumology

In partnership with: Paradigm Publishing Services

Publication frequency: Volume open

Keywords:

chronic obstructive pulmonary disease,

arterial hypertension,

angiotensinogen gene

Related subjects:

Clinical medicine,

Clinical medicine, other,

Internal medicine,

© 2020 Mariya Marushchak, Khrystyna Maksiv, Inna Krynytska, Kateryna Kozak, published by Romanian Society of Pneumology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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