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Experimental verification of the applicability of the AQURE IOERT accelerator for FLASH radiotherapy Cover

Experimental verification of the applicability of the AQURE IOERT accelerator for FLASH radiotherapy

Open Access
|Apr 2025

References

  1. Berry RJ, Hall EJ, Forster DW, Storr TH, Goodman MJ. Survival of mammalian cells exposed to X rays at ultra-high dose-rates. Br J Radiol. 1969;42(494):102-107. https://doi.org/10.1259/0007-1285-42-494-102
  2. Favaudon V, Caplier L, Monceau V, et al. Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice. Sci Transl Med. 2014;6(245). https://doi.org/10.1126/scitranslmed.3008973
  3. Calvo FA, Serrano J, Cambeiro M, et al. Intra-Operative Electron Radiation Therapy: An Update of the Evidence Collected in 40 Years to Search for Models for Electron-FLASH Studies. Cancers. 2022;14(15):3693. https://doi.org/10.3390/cancers14153693
  4. Bourhis J, Sozzi WJ, Jorge PG, et al. Treatment of a first patient with FLASH-radiotherapy. Radiother Oncol. 2019;139:18-22. https://doi.org/10.1016/j.radonc.2019.06.019
  5. Romano F, Bailat C, Jorge PG, Lerch MLF, Darafsheh A. Ultra‐high dose rate dosimetry: Challenges and opportunities for FLASH radiation therapy. Med Phys. 2022;49(7):4912-4932. https://doi.org/10.1002/mp.15649
  6. Lenartowicz-Gasik A, Misiarz A, Markopolski V, et al. Verification of real-time dosimetry of ultra-high dose rate beams at AQURE FLASH RT on the sample surface. Polish Journal of Medical Physics and Engineering. 2024;30(4). https://doi.org/10.2478/pjmpe-2024-0038
  7. Kruszyna-Mochalska M, Bijok M, Pawałowski B, et al. Zalecenia Polskiego Towarzystwa Fizyki Medycznej dotyczące kontroli jakości w radioterapii śródoperacyjnej promieniowaniem elektronowym (IOERT) za pomocą mobilnych akceleratorów. Inż Fiz Med. 8(1):7-25.
  8. Misiarz A, Lenartowicz A, Adrich P, et al. Design and performance validation of a novel 3d printed thin-walled and transparent electron beam applicators for intraoperative radiation therapy with beam energy up to 12 MeV. Rep Pract Oncol Radiother. 2024;29(3):329-339. https://doi.org/10.5603/rpor.101092
  9. Teledyne e2v. Magnetrons & Accessories. 2024. https://www.teledyne-e2v.com/en/solutions/rf-power/rf-devices/magnetrons/,”, 2023. [Online].
  10. Ashraf MR, Bruza P, Krishnaswamy V, Gladstone DJ, Pogue BW. Technical Note: Time‐gating to medical linear accelerator pulses: Stray radiation detector. Med Phys. 2019;46(2):1044-1048. https://doi.org/10.1002/mp.13311
  11. Adrich P. Technical Note: Monte Carlo study on the reduction in x‐ray contamination of therapeutic electron beams for Intraoperative Radiation Therapy by means of improvements in the design of scattering foils. Med Phys. 2019;46(8):3378-3384. https://doi.org/10.1002/mp.13647
  12. Ryczkowski A, Pawałowski B, Kruszyna-Mochalska M, et al. Commissioning, dosimetric characterisation and machine performance assessment of the AQURE mobile accelerator for intraoperative radiotherapy. Polish Journal of Medical Physics and Engineering. 2024;30(3):177-181. https://doi.org/10.2478/pjmpe-2024-0021
  13. Dróżdż A, Waluś M, Zieliński M, et al. Verification of electron beam parameters in an intraoperative linear accelerator using dosimetric and radiobiological response methods. Rep Pract Oncol Radiother. 2021;26(6):1029-1034. https://doi.org/10.5603/RPOR.a2021.0128
  14. van der Geer SB, de Loos MJ. Applications of the General Particle Tracer code. In: Proceedings of the 1997 Particle Accelerator Conference (Cat. No.97CH36167). Vol 2. IEEE; 1998:2577-2579. https://doi.org/10.1109/PAC.1997.751279
  15. de Loos MJ, van der Geer SB. GENERAL PARTICLE TRACER: A NEW 3D CODE FOR ACCELERATOR AND BEAM LINE DESIGN. In:; 1996:pp.e-proc. 1241.
  16. Elbashir FEM, Ksouri W, Eisa MH, et al. Comparison of Dosimetry Protocols for Electron Beam Radiotherapy Calibrations and Measurement Uncertainties. Life. 2021;12(1):31. https://doi.org/10.3390/life12010031
  17. IEC 60976 - Medical Electrical Equipment — Medical Electron Accelerators — Functional Performance Characteristics. International Electrotechnical Commission; 2007.
  18. Ashraf MR, Rahman M, Zhang R, et al. Dosimetry for FLASH Radiotherapy: A Review of Tools and the Role of Radioluminescence and Cherenkov Emission. Front Phys. 2020;8:328. https://doi.org/10.3389/fphy.2020.00328
  19. Petersson K, Jaccard M, Germond J, et al. High dose‐per‐pulse electron beam dosimetry — A model to correct for the ion recombination in the Advanced Markus ionization chamber. Med Phys. 2017;44(3):1157-1167. https://doi.org/10.1002/mp.12111
  20. Levy K, Natarajan S, Wang J, et al. Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice. Sci Rep. 2020;10(1):21600. https://doi.org/10.1038/s41598-020-78017-7
  21. Rohrer Bley C, Wolf F, Gonçalves Jorge P, et al. Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs. Clin Cancer Res. 2022;28(17):3814-3823. https://doi.org/10.1158/1078-0432.CCR-22-0262
  22. Biological effects in normal cells exposed to FLASH dose rate protons - PubMed. Accessed April 29, 2024. https://pubmed.ncbi.nlm.nih.gov/30850209/
  23. Karsch L, Beyreuther E, Burris-Mog T, et al. Dose rate dependence for different dosimeters and detectors: TLD, OSL, EBT films, and diamond detectors. Med Phys. 2012;39(5):2447-2455. https://doi.org/10.1118/1.3700400
  24. International Atomic Energy Agency. Absorbed Dose Determination in Photon and Electron Beams - An International Code of Practice. Technical Reports Series No. 277.; 1987.
  25. International Atomic Energy Agency. The Use of Plane Parallel Ionization Chambers in High Energy Electron and Photon Beams: An International Code of Practice for Dosimetry. Technical Reports Series No. 381. International Atomic Energy Agency; 1997.
  26. Atiq M, Atiq A, Iqbal K, Shamsi QA, Andleeb F, Buzdar SA. Interpretation of Gamma Index for Quality Assurance of Simultaneously Integrated Boost (SIB) IMRT Plans for Head and Neck Carcinoma. Pol J Med Phys Eng. 2017;23(4):93-97. https://doi.org/10.1515/pjmpe-2017-0016
  27. Low DA, Harms WB, Mutic S, Purdy JA. A technique for the quantitative evaluation of dose distributions. Med Phys. 1998;25(5):656-661. https://doi.org/10.1118/1.598248
  28. IntraOp. Product Datasheet Mobetron. IntraOp Mobetron HDR Product Datasheet. 2024. https://ezmpid78ed4.exactdn.com/wp-content/uploads/IntraOp_Mobetron_Data_Sheet-QN.r01.4-1.pdf
  29. Meyer J, Nyflot MJ, Smith WP, et al. Electron beam energy QA — a note on measurement tolerances. J Appl Clin Med Phys. 2016;17(2):249-257. https://doi.org/10.1120/jacmp.v17i2.6049
  30. Rosenberg I. Radiation Oncology Physics: A Handbook for Teachers and Students. Br J Cancer. 2008;98(5):1020-1020. https://doi.org/10.1038/sj.bjc.6604224
DOI: https://doi.org/10.2478/pjmpe-2025-0006 | Journal eISSN: 1898-0309 | Journal ISSN: 1425-4689
Language: English
Page range: 62 - 72
Submitted on: Jul 5, 2024
Accepted on: Nov 26, 2024
Published on: Apr 2, 2025
Published by: Polish Society of Medical Physics
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Aleksandra Lenartowicz-Gasik, Agnieszka Misiarz, Przemysław Adrich, Sławomir Wronka, Tomasz Piotrowski, Bartosz Pawałowski, Piotr Nowaczyk, Jan Trzuskowski, Jacek Rzadkiewicz, published by Polish Society of Medical Physics
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