Economic and Environmental Assessment of Cephapirin Use in Dry Cow Therapy of Holstein and Simmental Cows According to Parity
References
- Ajulo, S., & Awosile, B. (2024). Global antimicrobial resistance and use surveillance system (GLASS 2022): Investigating the relationship between antimicrobial resistance and antimicrobial consumption data across the participating countries. PLOS ONE, 19(2), e0297921. https://doi.org/10.1371/journal.pone.0297921
- Bengtsson-Palme, J., & Larsson, D. G. J. (2016). Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation. Environment International, 86, 140–149. https://doi.org/10.1016/j.envint.2015.10.015
- Berendsen, B. J. A., Wegh, R. S., Memelink, J., Zuidema, T., & Stolker, L. A. M. (2015). The analysis of animal faeces as a tool to monitor antibiotic usage. Talanta, 132, 258–268. https://doi.org/10.1016/j.talanta.2014.09.022
- Cortinhas, C. S., Oliveira, L., Hulland, C. A., Santos, M. V., & Ruegg, P. L. (2013). Minimum inhibitory concentrations of cephalosporin compounds and their active metabolites for selected mastitis pathogens. American Journal of Veterinary Research, 74(5), 683–690. https://doi.org/10.2460/ajvr.74.5.683
- Filippone Pavesi, L., Pollera, C., Sala, G., Cremonesi, P., Monistero, V., Biscarini, F., & Bronzo, V. (2023). Effect of the selective dry cow therapy on udder health and milk microbiota. Antibiotics, 12, 1259. https://doi.org/10.3390/antibiotics12081259
- Green, M. J., Green, L. E., Medley, G. F., Schukken, Y. H., & Bradley, A. J. (2002). Influence of dry period bacterial intramammary infection on clinical mastitis in dairy cows. Journal of Dairy Science, 85(10), 2589–2599. https://doi.org/10.3168/jds.S0022-0302(02)74343-9
- Guadagnini, M., Gogna, C., Tolasi, C., Tolasi, G., Gnali, G., Freu, G., Masroure, A. J., & Moroni, P. (2023). Approach to selective dry cow therapy in early adopter Italian dairy farms: Why compliance is so important. Animals, 13(22), 3485. https://doi.org/10.3390/ani13223485
- Halasa, T., Huijps, K., Østerås, O., & Hogeveen, H. (2007). Economic effects of bovine mastitis and mastitis management: A review. Veterinary Quarterly, 29(1), 18–31. https://doi.org/10.1080/01652176.2007.9695224
-
International Committee for Animal Recording (ICAR). (2017). ICAR recording guidelines: Overview of cattle milk recording. ICAR.
International Committee for Animal Recording (ICAR) . ( 2017 ). ICAR recording guidelines: Overview of cattle milk recording . ICAR .
- Kharel, M., Timisina, K. P., Adhikari, S. P., Dhakal, C., Khanal, D. R., & Paudel, T. P. (2023). Does mastitis cause economic loss in dairy cattle in Nepal? Nepal Agriculture Research Journal, 15(1), 55–65. https://doi.org/10.3126/narj.v15i1.51064
- Kupczyński, R., Bednarski, M., Sokołowski, M., Kowalkowski, W., & Pacyga, K. (2024). Comparison of antibiotic use and the frequency of diseases depending on the size of herd and the type of cattle breeding. Animals, 14(13), 1889. https://doi.org/10.3390/ani14131889
- Lipkens, Z., Piepers, S., & De Vliegher, S. (2023). Impact of selective dry cow therapy on antimicrobial consumption, udder health, milk yield, and culling hazard in commercial dairy herds. Antibiotics, 12, 901. https://doi.org/10.3390/antibiotics120509011
- Maksimović, Z., Čengić, B., Ćutuk, A., & Maksimović, A. (2023). Antimicrobial resistance of cattle mastitis-causing bacteria: How to treat? Veterinary Medicine and Science, 19. IntechOpen. https://doi.org/10.5772/intechopen.112977
- McCubbin, K. D., De Jong, E., Brummelhuis, C. M., Bodaneze, J., Biesheuvel, M., Kelton, D. F., Uyama, T., Dufour, S., Sanchez, J., Rizzo, D., Léger, D., & Barkema, H. W. (2023). Antimicrobial and teat sealant use and selection criteria at dry-off on Canadian dairy farms. Journal of Dairy Science, 106(10), 7104–7116. https://doi.org/10.3168/jds.2022-23083
- Medical Intertrade d.o.o. (2025). Ponuda za antibiotike: Mastidry, Cefa-Safe, Orbeseal, Keraseal (Ponuda br. 12379/2025, 12. lipnja 2025). Zagreb: Medical Intertrade d.o.o.
- Müller, S., Nitz, J., Tellen, A., Klocke, D., & Krömker, V. (2023). Effect of antibiotic compared to non-antibiotic dry cow treatment on the bacteriological cure of intramammary infections during the dry period: A retrospective cross-sectional study. Antibiotics, 12(3), 429. https://doi.org/10.3390/antibiotics12030429
- Navaei, H., Vodjgani, M., Khoramian, B., Akbarinejad, V., Gharagozloo, F., Garoussi, M. T., & Momeni, A. (2025). Evaluation of a new method of selective dry cow treatment using microbiological culture and antibiogram results. BMC Veterinary Research, 21(1). https://doi.org/10.1186/s12917-025-04767-z
- Očić, V., Bobić Šakić, B., & Grgić, Z. (2022). Economic analysis of specialized dairy farms in Croatia according to FADN. Mljekarstvo, 73(1), 50–58. https://doi.org/10.15567/mljekarstvo.2023.0106
- Peña-Mosca, F., Gaire, T. N., Dean, C., Ferm, P., Manriquez, D., Pinedo, P., Noyes, N., & Caixeta, L. (2025). Exploring the phylogenetic diversity and antimicrobial activity of non-aureus staphylococci and mammaliicocci isolated from teat apices of organic dairy cows. bioRxiv, 2024.02.01.578391. https://doi.org/10.1101/2024.02.01.578391
- Popescu, G., & Andrei, J. (2011). From industrial holdings to subsistence farms in Romanian agriculture. Analyzing the subsistence components of CAP. Agricultural Economics, 57(11), 555.
- Ribeiro, A. R., Sures, B., & Schmidt, T. C. (2018a). Cephalosporin antibiotics in the aquatic environment: A critical review of occurrence, fate, ecotoxicity and removal technologies. Environmental Pollution, 241, 1153–1166. https://doi.org/10.1016/j.envpol.2018.06.040
- Ribeiro, A. R., Sures, B., & Schmidt, T. C. (2018b). Ecotoxicity of the two veterinarian antibiotics ceftiofur and cefapirin before and after photo-transformation. Science of the Total Environment, 619–620, 866–873. https://doi.org/10.1016/j.scitotenv.2017.11.109
- Rowe, S. M., Godden, S. M., Nydam, D. V., Gorden, P. J., Lago, A., Vasquez, A. K., Royster, E., Timmerman, J., & Thomas, M. J. (2020). Randomized controlled trial investigating the effect of 2 selective dry-cow therapy protocols on udder health and performance in the subsequent lactation. Journal of Dairy Science, 103(7), 6493–6503. https://doi.org/10.3168/jds.2019-17961
- Seegers, H., Fourichon, C., & Beaudeau, F. (2003). Production effects related to mastitis and mastitis economics in dairy cattle herds. Veterinary Research, 34(5), 475–491. https://doi.org/10.1051/vetres:2003027
- Smith, J. W., Ely, L. O., & Chapa, A. M. (2000). Effect of region, herd size, and milk production on reasons cows leave the herd. Journal of Dairy Science, 83(12), 2980–2987. https://doi.org/10.3168/jds.S0022-0302(00)75198-8
- Stocco, G., Cipolat-Gotet, C., Stefanon, B., Zecconi, A., Francescutti, M., Mountricha, M., & Summer, A. (2023). Herd and animal factors affect the variability of total and differential somatic cell count in bovine milk. Journal of Animal Science, 101, skac406. https://doi.org/10.1093/jas/skac406
- Stockler, R. M., Morin, D. E., Lantz, R. K., & Constable, P. D. (2009). Effect of milking frequency and dosing interval on the pharmacokinetics of cephapirin after intramammary infusion in lactating dairy cows. Journal of Dairy Science, 92(9), 4262–4275. https://doi.org/10.3168/jds.2008-1916
- Tell, J., Caldwell, D. J., Häner, A., Hellstern, J., Hoeger, B., Journel, R., Mastrocco, F., Ryan, J. J., Snape, J., Straub, J. O., & Vestel, J. (2019). Science-based targets for antibiotics in receiving waters from pharmaceutical manufacturing operations. Integrated Environmental Assessment and Management, 15(3), 312–319. https://doi.org/10.1002/ieam.4141
- Thiele-Bruhn, S. (2003). Pharmaceutical antibiotic compounds in soils – a review. Journal of Plant Nutrition and Soil Science, 166(2), 145–167. https://doi.org/10.1002/jpln.200390023
- Tomanić, D., Samardžija, M., Stančić, I., Kladar, N., Maćešić, N., & Kovačević, Z. (2024). Mastitis challenges in Serbian dairy farming: A study on somatic cell counts and pathogen distribution. Mljekarstvo, 239–248. https://doi.org/10.15567/mljekarstvo.2024.0307
- Vanhoudt, A., van Hees-Huijps, K., van Knegsel, A. T. M., Sampimon, O. C., Vernooij, J. C. M., Nielen, M., & van Werven, T. (2018). Effects of reduced intramammary antimicrobial use during the dry period on udder health in Dutch dairy herds. Journal of Dairy Science, 101(4), 3248–3260. https://doi.org/10.3168/jds.2017-13555
- Vissio, C., Richardet, M., Issaly, L. C., & Larriestra, A. J. (2023). Decision making on dry cow therapy: Economic evaluation using field data under Argentinian production conditions. Ciência e Agrotecnologia, 47, e016322. https://doi.org/10.1590/1413-7054202347016322
- Weber, J., Borchardt, S., Seidel, J., Schreiter, R., Wehrle, F., Donat, K., & Freick, M. (2021). Effects of selective dry cow treatment on intramammary infection risk after calving, cure risk during the dry period, and antibiotic use at drying-off: A systematic review and metaanalysis of current literature (2000–2021). Animals, 11(12), 3403. https://doi.org/10.3390/ani111234036
DOI: https://doi.org/10.2478/picbe-2026-0343 | Journal eISSN: 2558-9652
Language: English
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Published on: Jul 23, 2026
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© 2026 Boris LJUBOJEVIĆ, Dragan SOLIĆ, Roxana Elena LEPADATU, Vesna GANTNER, published by Bucharest University of Economic Studies
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