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The Effect of Ketoprofen Lysine Salt on Blood Morphology, Biochemical Blood Parameters and Superoxide Dismuthase Activity in Rat’s Kidney Cover

The Effect of Ketoprofen Lysine Salt on Blood Morphology, Biochemical Blood Parameters and Superoxide Dismuthase Activity in Rat’s Kidney

Open Access
|Jan 2026

References

  1. Characteristics of the medicinal product Ketonal Sprint, 25 mg, granules for oral use, in a sachet and Ketonal Sprint Max, 50 mg, granules for oral use, in a sachet. Cited on March 11 2025.
  2. Woroń J. Ketoprofen with lysine in pain pharmacotherapy, or how can I effectively improve the effectiveness and safety of known NSAID? Leki w POZ. 2019;5:389-393.
  3. Woroń J., Wordliczek J., Dobrogowski J. Porównanie niesteroidowych leków przeciwzapalnych (NLPZ). Medycyna po Dyplomie. 2011(20);6(183):55-63.
  4. Cashman J. N. The mechanisms of action of NSAIDs in analgesia. Drugs. 1996;52(5):13-23.
  5. Zaremba M., Staniszewska A., Niewada M. Nonsteroidal anti-inflammatory drugs; facts, myths and controversies about the cardiovascular risk and complications of the gastrointestinal tract. Choroby Serca i naczyń. 2012;9(3):119-135.
  6. Goździalska A., Jaśkiewicz J. Mechanizm działania niesteroidowych leków przeciwzapalnych. Państwo i Społeczeństwo. 2014;1:85-95.
  7. Woroń J., Wordliczek J., Malec-Milewska M. Analgetyki nieopioidowe wykazujące działanie przeciwzapalne in Dobrogowski J., Wordliczek J., Kocot-Kępska M. Ból. Termedia Wydawnictwo Medyczne. 2020;5:41-50.
  8. Harvanová G., Duranková S. Inflammatory process: factors inducing inflammation, forms and manifestations of inflammation, immunological significance of the inflammatory reaction. Alergologia Polska - Polish Journal of Allergology. 2025;12(1):54-61.
  9. Czarkowska-Pączek B. Zapalenia ostre i przewlekłe in Badowska-Kozakiewicz A. M. Patofizjologia człowieka. Wydawnictwo Lekarskie PZWL. 2013;I.3:31-55.
  10. Abdulkhaleq L. A., Assi M. A., Abdullah R., Zamri-Saad M., Taufiq-Yap Y. H., Hezmee M. N. M. The crucial roles of inflammatory mediators in inflammation. Veterinary world, 2018;11(5):627–635.
  11. Kulbacka J., Saczko J., Chwiłkowska A. Stres oksydacyjny w procesach uszkodzenia komórek. Pol. Merk. Lek. 2009;157:44-46.
  12. Karpińska A., Gromadzka G. Oxidative stress and natural antioxidant mechanisms: the role in neurodegeneration. From molecular mechanisms to therapeutic strategies. Postepy higieny i medycyny doswiadczalnej. 2013;67:43-53.
  13. Yoshikawa T., You F. Oxidative Stress and Bio-Regulation. Int J Mol Sci. 2024;25(6):3360-66.
  14. Younus H. Therapeutic potentials of superoxide dismutase. Int J Health Sci (Qassim). 2018;12(3):88-93.
  15. Bloom J. C.,Brandt J. T. Działanie hematologiczne in Klaassen C. D., Watkins III J. B. Casarett&Doull Podstawy toksykologii. MedPharm Polska. 2014;11:205-220.
  16. Bhattacharyya A., Chattopadhyay R., Mitra S., Crowe S. E. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. 2014;94(2):329-354.
  17. Schnellmann R. G. Nefrotoksyczne działanie ksenobiotyków in Klaassen C. D., Watkins III J. B. Casarett&Doull Podstawy toksykologii. MedPharm Polska. 2014;14:261-276.
  18. Czarkowska-Pączek B. Patofizjologia nerek in Badowska-Kozakiewicz A. M. Patofizjologia człowieka. Wydawnictwo Lekarskie PZWL. 2013;II.10:331-361.
  19. Nieradko-Iwanicka B., Ruszel K., Herbet M., Pawłowski K. Możliwy efekt immunomodulacyjny ketoprofenu i soli lizynowej ketoprofenu na mózg. Polish Hyperbaric Research. 2024;88(3):87-93.
  20. Nieradko-Iwanicka B., Ruszel K. Nutritional status of female rats after acute intoxication with ethyl alcohol and treatment with ketoprofen lysine salt or ketoprofen. Curr. Issues Pharm. Med. Sci. 2024;4(37):221-225.
  21. Cimini A., Brandolini L., Gentile R., Cristiano L., Menghini P., Fidoamore A., Antonosante A., Benedetti E., Giordano A., Allegretti M. Gastroprotective effects of L-lysine salification of ketoprofen in ethanol-injured gastric mucosa. J Cell Physiol. 2015;230(4):813-820.
  22. Ruszel K., Nieradko-Iwanicka B., Naja-Wiśniewska M., Wójtowicz P. Ketoprofen lysine salt has no gastroprotective effect in comparison with ketoprofen in female rats after ethyl alcohol intoxication. Polish Hyperbaric Research. 2023;3(84):69-79.
  23. Novelli R., Aramini A., Boccella S., et al. Ketoprofen lysine salt has a better gastrointestinal and renal tolerability than ketoprofen acid: A comparative tolerability study in the Beagle dog. Biomed Pharmacother. 2022;153:113336-42.
  24. Zhang Y., Yu W., Han D., Meng J., Wang H., Cao G. L-lysine ameliorates sepsis-induced acute lung injury in a lipopolysaccharide-induced mouse model. Biomed Pharmacother. 2019;118:109307-12.
  25. Kuczyńska J., Nieradko-Iwanicka B. The effect of ketoprofen lysine salt on mucosa of rat stomach after ethyl alcohol intoxication. Biomedicine & Pharmacotherapy. 2011;139:1-8.
  26. Rataj J., Chałubiński M., Gawrysiak M. Potentially protective role of eosinophils in respiratory virus infections. Alergia Astma Immunologia. 2024;29(4):148-160.
  27. Gajewski M., Rzodkiewicz P., Maśliński S. Current view on the role of neutrophils in rheumatoid arthritis. Still neutrophiles or maybe already microphages? Reumatologia. 2011;49(5):344–350.
  28. Kuczyńska J., Nieradko-Iwanicka B. Comparison of the effects of ketoprofen and ketoprofen lysine salt on the Wistar rats’ nervous system, kidneys and liver after ethyl alcohol intoxication. Biomed Pharmacother. 2023;161:114456-64.
  29. Fuss J., Voloboyeva A., Polovyj V., Yaremkevych R. Neutrophil to lymphocyte ratio in predicting postoperative complications and prognosis in patients with colorectal cancer. Pol Przegl Chir. 2022;94(6):33-37.
  30. Kuźniar-Placek J. The meaning of neutrophil-lymphocyte ratio in patients with cardiovascular diseases. Folia Cardiologica. 2016;11(6):525-528.
  31. Wójcik E., Stasik Z., Rychlik U., et al. Prognostic value of Platelet-to-Lymphocyte Ratio (PLR) and IL-6 in patients with small cell lung cancer. Diagn Lab. 2018;54(3):137-144.
  32. Xu Z., Zhang J., Zhong Y., Mai Y., Huang D., Wei W., Huang J., Zhao P., Lin F., Jin J. Predictive value of the monocyte-to-lymphocyte ratio in the diagnosis of prostate cancer. Medicine (Baltimore). 2021;100(38):27244-54.
  33. Wiąk-Walerowicz K., Wielosz E. Ocena zależności między wskaźnikami hematologicznymi a czasem trwania remisji u chorych na spondyloartropatie zapalne leczonych inhibitorami czynnika martwicy nowotworu. Reumatologia. 2024;62(1):15-15.
  34. Marseglia G. L., Veraldi D., Ciprandi G. Study Group on Respiratory Infections in Adolescents. Ketoprofen lysine salt treatment in adolescents with acute upper respiratory infections: a primary-care experience. Minerva Pediatr (Torino). 2023;75(6):890-895.
  35. Ciprandi G., Scaglione F. Ketoprofen and ketoprofen lysine salt in managing children with mild-moderate acute pain: evidence emerging from comparative trials. Panminerva Med. Published online March 12, 2025: 15-25.
DOI: https://doi.org/10.2478/phr-2025-0020 | Journal eISSN: 2084-0535 | Journal ISSN: 1734-7009
Language: English
Page range: 75 - 88
Submitted on: May 13, 2025
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Accepted on: Jun 13, 2025
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Published on: Jan 22, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2026 Patrycja Tokarska, Barbara Nieradko-Iwanicka, published by Polish Hyperbaric Medicine and Technology Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.