Zinc and Magnesium vs COVID - 19

Sokołowska, Barbara; Nazaruk, Stanisława Katarzyna; Radzka-Pogoda, Agnieszka; Henrykowska, Gabriela; Borzęcki, Andrzej

doi:10.2478/phr-2022-0009

Abstract

Zinc and magnesium are among the most important elements for the human body. A deficiency or excess of either of them may pose a potential threat to the homeostatic mechanisms of the body. Both elements condition the proper functioning of the immune system. Zinc and magnesium deficiency significantly reduces the body's immunity, facilitating infection with various pathogens, including SARS-COV-2 infection. In this paper, we reviewed the literature on the impact of zinc and magnesium deficiencies on the incidence and course of COVID-19.

References

Zhang E., He W., Du H., Yang K. (2008). Microstructure, mechanical properties and corrosion properties of Mg–Zn–Y alloys with low Zn content. Materials Science and Engineering A 488 (2008) 102–11. doi:10.1016/j.msea.2007.10.056;
Search in Google Scholar Back to article
Human Vitamin and Mineral Requirements. Report of a joint FAO/WHO expert consultation Bangkok, Thailand. Food and Agriculture Organization of the United Nations. World Health Organization. Food and Nutrition Division FAO Rome.FAO 2001;
Search in Google Scholar Back to article
Maier J. A., Pickerging G., Giacomoni E., Cazzaniga A., Pellegrino P. (2020). Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate. Nutriens,12(9):2660.doi: 10.3390/nu12092660;
Search in Google Scholar Back to article
Trapani V., Rosanoff A., Baniasadi S., Barbagallo M., Castiglioni S., Guerrero-Romero F., Iotti S., Mazur A., Micke O., Pourdowlat G., Scarpati G., Wolf F.I., Maier J.A. (2022).The relevance of magnesium homeostasis in COVID-19. European Journal of Nutrition, volume 61(2):625-636. doi: 10.1007/s00394-021-02704-y;
Search in Google Scholar Back to article
Razzaque M.S. Magnesium: Are W e Consuming Enough? Nutrients. 2018; 10(12): 1863. doi: 10.3390/nu10121863;
Search in Google Scholar Back to article
Medeiros de Morais C. (2021). Nutritional therapy in COVID-19 management. Kompass Nutr Diet. 1:10-12. doi:10.1159/000512853;
Search in Google Scholar Back to article
Coman AE., Ceasovschih A., Petroaie D.A., Popa E. Lionte C., BologaC., HaligaR.E., Cosmescu A., Slănină A.M., Bacușcă A.I., Șorodoc V., Șorodoc L. (2023). The Significance of Low Magnesium Levels in COVID-19 Patients. Medicina, 59(2),279. doi: 10.3390/medicina59020279;
Search in Google Scholar Back to article
Fan Y, Pedersen O. (2021). Gut microbiota in human metabolic health and disease. Nat Rev Microbiol 19:55–71. doi:10.1038/s41579-020-0433-9;
Search in Google Scholar Back to article
Jarosz M., Rychlik E., Stoś K., Charzewska J. ( red.)(2020) Nutrition standards for the Polish population and their application. Warszawa: Narodowy Instytut Zdrowia Publicznego – Państwowy Zakład Higieny. ISBN:978-83-65870-28-5;
Search in Google Scholar Back to article
Hu B., Guo H., Zhou P., Shi, ZL. (2021). Characteristics of SARS-CoV-2 and COVID-19. Nat. Rev. Microbiol.19, 141-154.doi:10.1038/s41579-020-00459-7;
Search in Google Scholar Back to article
Ye Q, Wang B, Mao J., Fu J., Shang S., Shu Q., Zhang T. Epidemiological analysis of COVID-19 and practical experience from China. J Med Virol 2020; 92: 755-769;
Search in Google Scholar Back to article
Harrison SL., Fazio-Eynullayeva E., Lane DA. Underhill P., Lip G.Y.H (2020). Comorbidities associated with mortality in 31,461 adults with COVID-19 in the United States: a federated electronic medical record analysis. PLoS Med,17:1003321. doi.10.1371/journal.pmed.1003321;
Search in Google Scholar Back to article
Salinas Aguirre JE., Sánchez García C., Rodríguez Sanchez R., Rodríguez-Sanchez R., Rodríguez-Muñoz L., Díaz-Castaño A., Bernal-Gómez R. (2021). Clinical characteristics and comorbidities associated with mortality in patients with COVID-19 in Coahuila (Mexico). Rev Clin Esp, 222(5): 288–292. doi: 10.1016/j.rceng.2020.12.007;
Search in Google Scholar Back to article
Mikulec A., Zborowski M., Cisoń-Apanasewicz U., Stawiarska A., Kowalski S.(2022). Impact of the COVID-19 pandemic on the eating behaviour of children and adolescents. Food. Science. Technology. Quality, 29, 3 (132),42-55. doi:10.15193/zntj/2022/132/422;
Search in Google Scholar Back to article
Galluccio A., Caparello G., Avolio E., Manes E., Ferraro S., Giordano C., Sisci D., Bonofiglio D. (2021). Self-perceived physical activity and adherence to the Mediterranean diet in healthy adolescents during COVID-19: findings from the DIMENU pilot study. Healthcare, 9(6), 622. doi: 10.3390/healthcare9060622;
Search in Google Scholar Back to article
Khan M., Moverley-Smith JE.(2020). "Covibesity," a new pandemic. Obes. Med.19,100282. doi: 10.1016/j.obmed.2020.100282;
Search in Google Scholar Back to article
Dunn C.G., Kenney E., Fleischhacker S.E., Bleich S.N.(2020). Feeding low-income children during the covid-19 pandemic. N. Engl. J. Med.382(18):e40. doi:10.1056/NEJMp2005638;
Search in Google Scholar Back to article
Dunton G.F., Do B., Wang S.D. (2020). Early effects of the COVID-19 pandemic on physical activity and sedentary behavior in children living in the U.S. BMC Public Health. 4;20 (1): 1351.doi:10.1186/s12889-020-09429-3;
Search in Google Scholar Back to article
Wolf FI., Maier JA., Rosanoff A., et al. (2021). The magnesium global network (MaGNet) to promote research on magnesium in diseases focusing on COVID-19. Magnes Res, 34:90–92. doi:10.1684/mrh.2021.0479;
Search in Google Scholar Back to article
Alamdari N.M., Afaghi S., Rahimi F.S., Tarki F.E., Tavana S., Zali A., Fathi M., Besharat S., Bagheri L., Pourmotahari F., Irvani S.S.N., Dabbagh A, Mousavi S.A. Mortality Risk Factors among Hospitalized COVID-19 Patients in a Major Referral Center in Iran. Tohoku J Exp Med. 2020, 252(1), 73-84];
Search in Google Scholar Back to article
Goshua G., Pine AB., Meizlish ML. et al. (2020). Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. Lancet Haematol,7:575-582. doi: 10.1016/S2352-3026(20)30216-7;
Search in Google Scholar Back to article
Perico L., Benigni A., Casiraghi F. et al. (2021). Immunity, endothelial injury and complement-induced coagulopathy in COVID-19. Nat Rev Nephrol,17:46–64. doi:10.1038/s41581-020-00357-4;
Search in Google Scholar Back to article
Sheu JR., Hsiao G., Shen M-Y. et al. (2002). Mechanisms involved in the antiplatelet activity of magnesium in human platelets. Br J Haematol, 2002;119:1033-1041; doi:10.1046/j.1365-2141.2002.03967.x;
Search in Google Scholar Back to article
Sarvazad H., Cahngaripour SH., Eskandari Roozbahani N., Izadi B. (2020). Evaluation of electrolyte status of sodium, potassium and magnesium and fasting blood sugar at the initial admission of individuals with COVID-19 without underlying disease in Golestan Hospital. Kermanshah New Microbes New Infect, 38:100807.doi:10.1016/j.nmni.2020.100807;
Search in Google Scholar Back to article
Wallace TC. (2020). Combating COVID-19 and building immune resilience: a potential role for magnesium nutrition? J Am Coll Nutr, 39:685-693.doi:10.1080/07315724.2020.1785971;
Search in Google Scholar Back to article
Pour OB., Yahyavi Y., Karimi A., Khamaneh AM., Milani M., Khalili M., Sharifi A. (2021). Serum trace elements levels and clinical outcomes among Iranian COVID-19 patients. Int J Infect Dis, 111:164-168. doi: 10.1016/j.ijid.2021.08.053;
Search in Google Scholar Back to article
Wessels I., Rolles B., Rink L. (2020). The potential impact of zinc supplementation on COVID-19 pathogenesis. Front Immunol, 11:1712. doi:10.3389/fimmu.2020.01712;
Search in Google Scholar Back to article
Wessels I., Rolles B., Slusarenko AJ., Rink L. (2022). Zinc deficiency as a possible risk factor for increased susceptibility and severe progression of Corona Virus Disease 19. Br J Nutr, 127(2):214-232. doi:10.1017/S0007114521000738;
Search in Google Scholar Back to article
Hoang BX., Han B. (2020). A possible application of hinokitiol as a natural zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and viral infections. Med Hypotheses,145:110333. doi:10.1016/j.mehy.2020.110333;
Search in Google Scholar Back to article
Fan L.,Cui Y., Liu Z.,Guo J., Gong X.,Zhang Y., Tang W.,Zhao J., Xue Q. (2023). Zinc and selenium status in coronavirus disease 2019, BioMetals,19:53:45. doi:10.1007/s10534-023-00501-0;
Search in Google Scholar Back to article
Derwand R., Scholz M., Zelenko V. (2020). COVID-19 outpatients: early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: a retrospective case series study. Int J Antimicrob Agents, 56(6):106214. doi:10.1016/j.ijantimicag.2020.106214;
Search in Google Scholar Back to article
Jothimani D., Venugopal R., Abedin MF., Kaliamoorthy I., Rela M. (2020). COVID-19 and the liver. Journal of Hepatology, vol. 73,1231–1240. doi:10.1016/j.jhep.2020.06.006;
Search in Google Scholar Back to article
Im JH., Je YS., Baek J., Chung MH., Kwon HY., Lee JS. (2020). Nutritional status of patients with COVID-19. Int J Infect Dis, 100:390-393. doi:10.1016/j.ijid.2020.08.018;
Search in Google Scholar Back to article
Talha KA., Patwary MI., Alam ZN., Ali SM., Ahmed S., Nafee A.,Selina F., Khan MH., Shusmita FR., Avi SG., Rahman MN. (2022). Case-Control Study to Evaluate Zinc Deficiency as a Risk Factor for Oxygen Requirement in Patients with COVID-19. Mymensingh Med J, 31(1):216-222. PMID: 34999705;
Search in Google Scholar Back to article
Shang W., Dong J., Ren Y., Tian M., Li W., Hu J., Li Y. (2020). The value of clinical parameters in predicting the severity of COVID-19. J Med Virol,92(10):2188–2192. doi:10.1002/jmv.26031;
Search in Google Scholar Back to article
Patel O., Chinni V., El-Khoury J., Perera M., Neto AS., McDonald C., See E., Jones D., Bolton D., Bellomo R., Trubiano J., Ischia J. (2021). A pilot double-blind safety and feasibility randomized controlled trial of high-dose intravenous zinc in hospitalized COVID-19 patients. J Med Virol, 93(5):3261-3267.doi:10.1002/jmv.26895;
Search in Google Scholar Back to article
Abd-Elsalam S., Soliman S., Esmail ES., Khalaf M., Mostafa EF., Medhat MA., Ahmed OA., El Ghafar MSA., Alboraie M., Hassany SM. (2021). Do zinc supplements enhance the clinical efficacy of hydroxychloroquine?: A randomized multicenter trial. Biol Trace Elem Res, 199(10):3642-3646. doi:10.1007/s12011-020-02512-1;
Search in Google Scholar Back to article
Thomas S., Patel D., Bittel B., Wolski K., Wang Q., Kumar A., Il’Giovine ZJ., Mehra R., McWilliams C., Nissen SE., Desai MY. (2021). Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection: the COVID A to Z randomized clinical trial. JAMA Netw Open, 4(2):210369. doi:10.1001/jamanetworkopen.2021.0369;
Search in Google Scholar Back to article
Kiran Kumar PVSN, Tomo S., Purohit P., Sankanagoudar S.,et al. (2023). Comparative Analysis of Serum Zinc, Copper and Magnesium Level and Their Relations in Association with Severity and Mortality in SARS-CoV-2 Patients. Biological Trace Element Research, 201(1):23-30.doi: 10.1007/s12011-022-03124-7;
Search in Google Scholar Back to article
Tsuchiya H. (2022). Gustatory and Saliva Secretory Dysfunctions in COVID-19 Patients with Zinc Deficiency. Life (Basel),12(3):353. doi: 10.3390/life12030353.
Search in Google Scholar Back to article

Zinc and Magnesium vs COVID - 19

Abstract

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