Diagnostic value of insulin resistance-based biomarkers in arterial hypertension
References
- Dorobantu M, Tautu OF, Dimulescu D, Sinescu C, Gusbeth-Tatomir P, Arsenescu Georgescu C, et al. Perspectives on hypertension’s prevalence, treatment and control in a high cardiovascular risk East European country: data from the SEPHAR III survey. J Hypertens. 2018;36(3):690-700.
- Hou Y, Yang S. Association of risk factors for high blood pressure across 46 low- and middle-income countries: A multi-country cross-sectional analysis. J Glob Health. 2024;14:04087. doi:10.7189/jogh.14.04087.
- Freeman AM, Acevedo LA, Pennings N. Insulin resistance. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025.
- Gołacki J, Matuszek M, Matyjaszek-Matuszek B. Link between insulin resistance and obesity-From diagnosis to treatment. Diagnostics. 2022;12:1681. doi:10.3390/diagnostics12071681.
- Strings S, Wells C, Bell C, Tomiyama AJ. The association of body mass index and odds of type 2 diabetes mellitus varies by race/ethnicity. Public Health. 2023;215:27-30. doi:10.1016/j. puhe.2022.11.017.
- Lee J, Kim MH, Jang JY, Oh CM. Assessment of HOMA as a predictor for new-onset diabetes mellitus and diabetic complications in non-diabetic adults: a KoGES prospective cohort study. Clin Diabetes Endocrinol. 2023;9:7. doi:10.1186/s40842-023-00156-3.
- Hou XZ, Lv YF, Li YS, et al. Association between different insulin resistance surrogates and all-cause mortality in patients with coronary heart disease and hypertension: NHANES longitudinal cohort study. Cardiovasc Diabetol. 2024;23:86. doi:10.1186/s12933-024-02173-7.
- Ramdas Nayak VK, Satheesh P, Shenoy MT, Kalra S. Triglyceride glucose (TyG) index: A surrogate biomarker of insulin resistance. J Pak Med Assoc. 2022;72:986-988. doi:10.47391/JPMA.22-63.
- Li W, Shen C, Kong W, Zhou X, Fan H, Zhang Y, et al. Association between the triglyceride glucose-body mass index and future cardiovascular disease risk in a population with Cardiovascular-Kidney-Metabolic syndrome stage 0-3: a nationwide prospective cohort study. Cardiovasc Diabetol. 2024;23:292. doi:10.1186/s12933-024-02352-6.
- Ren XX, Chen ZA, Zheng S, Han TT, Li YX, Liu W, Hu YM. Association between triglyceride to HDL-C ratio and insulin resistance in Chinese patients with newly diagnosed type 2 diabetes mellitus. PLoS One. 2016;11:e0154345. doi: 10.1371/journal.pone.0154345.
- Baneu P, Văcărescu C, Drăgan SR, et al. The triglyceride/HDL ratio as a surrogate biomarker for insulin resistance. Biomedicines. 2024;12:1493. doi:10.3390/biomedicines12071493.
- Zhou C, Zhang Y, Liu X, et al. Relationship of METS-IR with cardiometabolic multimorbidity in China: a nationwide longitudinal cohort study. Front Nutr. 2025;12:1518840. doi:10.3389/fnut.2025.1518840.
- Song X, He Y, Cai Z, Peng L. Association between five insulin resistance indices and cardiometabolic diseases: NHANES study. Medicine (Baltimore). 2026;105:e48080. doi: 10.1097/MD.0000000000048080.
- Ştefan AG, Clenciu D, Mitrea A, et al. Metabolic syndrome and insulin resistance in Romania. Int J Mol Sci. 2025;26:2389. doi:10.3390/ijms26062389.
- Liu L, Yu G, Ji X, et al. Associations of insulin resistance-related indices with cardio-renal-metabolic multimorbidity: UK Biobank study. Cardiovasc Diabetol. 2025;24:377. doi:10.1186/s12933-025-02928-w.
- Zeng P, Cai X, Yu X, et al. Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic population. Sci Rep. 2023;13:20470. doi:10.1038/s41598-023-47269-4.
- Pan A, Wang Y, Talaei M, Hu FB, Wu T. Smoking and risk of type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies. Lancet Diabetes Endocrinol. 2015;3:958-967. doi:10.1016/S2213-8587(15)00316-2.
- Park MS. Triglyceride-glucose index predicts future metabolic syndrome in an adult population, Korea: a prospective cohort study. Ann Clin Nutr Metab. 2024;16:168-172.
- Song B, Zhao X, Yao T, et al. Triglyceride glucose-body mass index and risk of incident type 2 diabetes mellitus. Front Endocrinol. 2022;13:907973. doi:10.3389/fendo.2022.907973.
- de Almeida-Pititto B, Branda JI, de Oliveira JM, et al. The predictive value of the triglycerides/HDL-cholesterol ratio for diabetes incidence. Endocrines. 2024;5:418-429. doi:10.3390/endocrines5030031.
- Ndumele CE, Rangaswami J, Chow SL, et al. Cardiovascular-kidney-metabolic health: A presidential advisory from the American Heart Association. Circulation. 2023;148:1606-1635. doi:10.1161/CIR.0000000000001184.
- Gamsızkan Z, Onmez A, Sahin IE, et al. Can we use the triglyceride/HDL ratio to determine insulin resistance in obesity screening? Ankara Med J. 2022;22:451-459. doi:10.5505/amj.2022.38991.
- Tian Z, Yang L, Li Y, et al. Insulin resistance indices and cardiometabolic multimorbidity: UK Biobank study. Cardiovasc Diabetol. 2025;24:257. doi:10.1186/s12933-025-02819-0.
DOI: https://doi.org/10.2478/orvtudert-2026-0008 | Journal eISSN: 2537-5059 | Journal ISSN: 1453-0953
Language: English
Page range: 112 - 124
Published on: Jul 11, 2026
Published by: Transylvanian Museum Society
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
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© 2026 Fazakas Aliz-Nóra, Pászka Alpár, Magdás Annamária, published by Transylvanian Museum Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.